McGill University

About: McGill University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Context (language use). The organization has 72688 authors who have published 162565 publications receiving 6966523 citations. The organization is also known as: Royal institution of advanced learning & University of McGill College.

Recent patterns of crop yield growth and stagnation

Abstract: In the coming decades, continued population growth, rising meat and dairy consumption and expanding biofuel use will dramatically increase the pressure on global agriculture. Even as we face these future burdens, there have been scattered reports of yield stagnation in the world's major cereal crops, including maize, rice and wheat. Here we study data from ∼2.5 million census observations across the globe extending over the period 1961-2008. We examined the trends in crop yields for four key global crops: maize, rice, wheat and soybeans. Although yields continue to increase in many areas, we find that across 24-39% of maize-, rice-, wheat- and soybean-growing areas, yields either never improve, stagnate or collapse. This result underscores the challenge of meeting increasing global agricultural demands. New investments in underperforming regions, as well as strategies to continue increasing yields in the high-performing areas, are required.

Surgery decreases long-term mortality, morbidity, and health care use in morbidly obese patients.

Abstract: Objective: This study tested the hypothesis that weight-reduction (bariatric) surgery reduces long-term mortality in morbidly obese patients. Background: Obesity is a significant cause of morbidity and mortality. The impact of surgically induced, long-term weight loss on this mortality is unknown. Methods: We used an observational 2-cohort study. The treatment cohort (n = 1035) included patients having undergone bariatric surgery at the McGill University Health Centre between 1986 and 2002. The control group (n = 5746) included age- and gender-matched severely obese patients who had not undergone weight-reduction surgery identified from the Quebec provincial health insurance database. Subjects with medical conditions (other then morbid obesity) at cohort-inception into the study were excluded. The cohorts were followed for a maximum of 5 years from inception. Results: The cohorts were well matched for age, gender, and duration of follow-up. Bariatric surgery resulted in significant reduction in mean percent excess weight loss (67.1%, P < 0.001). Bariatric surgery patients had significant risk reductions for developing cardiovascular, cancer, endocrine, infectious, psychiatric, and mental disorders compared with controls, with the exception of hematologic (no difference) and digestive diseases (increased rates in the bariatric cohort). The mortality rate in the bariatric surgery cohort was 0.68% compared with 6.17% in controls (relative risk 0.11, 95% confidence interval 0.04-0.27), which translates to a reduction in the relative risk of death by 89%. Conclusions: This study shows that weight-loss surgery significantly decreases overall mortality as well as the development of new health-related conditions in morbidly obese patients.

Robust receding horizon control of constrained nonlinear systems

Abstract: We present a method for the construction of a robust dual-mode, receding horizon controller which can be employed for a wide class of nonlinear systems with state and control constraints and model error. The controller is dual-mode. In a neighborhood of the origin, the control action is generated by a linear feedback controller designed for the linearized system. Outside this neighborhood, receding horizon control is employed. Existing receding horizon controllers for nonlinear, continuous time systems, which are guaranteed to stabilize the nonlinear system to which they are applied, require the exact solution, at every instant, of an optimal control problem with terminal equality constraints. These requirements are considerably relaxed in the dual-mode receding horizon controller presented in this paper. Stability is achieved by imposing a terminal inequality, rather than an equality, constraint. Only approximate minimization is required. A variable time horizon is permitted. Robustness is achieved by employing conservative state and stability constraint sets, thereby permitting a margin of error. The resultant dual-mode controller requires considerably less online computation than existing receding horizon controllers for nonlinear, constrained systems. >

Organic chemistry in water

Abstract: Water has emerged as a versatile solvent for organic chemistry in recent years. Water as a solvent is not only inexpensive and environmentally benign, but also gives completely new reactivity. The types of organic reactions in water are broad including pericyclic reactions, reactions of carbanion equivalent, reactions of carbocation equivalent, reactions of radicals and carbenes, transition-metal catalysis, oxidations-reductions, which we discuss in this tutorial review. Aqueous organic reactions have broad applications such as synthesis of biological compounds from carbohydrates and chemical modification of biomolecules.

Soot: a Java bytecode optimization framework

Abstract: This paper presents Soot, a framework for optimizing Java* bytecode. The framework is implemented in Java and supports three intermediate representations for representing Java bytecode: Baf, a streamlined representation of bytecode which is simple to manipulate; Jimple, a typed 3-address intermediate representation suitable for optimization; and Grimp, an aggregated version of Jimple suitable for decompilation. We describe the motivation for each representation, and the salient points in translating from one representation to another. In order to demonstrate the usefulness of the framework, we have implemented intraprocedural and whole program optimizations. To show that whole program bytecode optimization can give performance improvements, we provide experimental results for 12 large benchmarks, including 8 SPECjvm98 benchmarks running on JDK 1.2 for GNU/Linuxtm. These results show up to 8% improvement when the optimized bytecode is run using the interpreter and up to 21% when run using the JIT compiler.