Institution
McMaster University
Education•Hamilton, Ontario, Canada•
About: McMaster University is a education organization based out in Hamilton, Ontario, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 41361 authors who have published 101269 publications receiving 4251422 citations.
Papers published on a yearly basis
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TL;DR: It is found that, when maintained under germ-free conditions, mice do not display an age-related increase in circulating pro-inflammatory cytokine levels, suggesting that aging-associated microbiota promote inflammation and that reversing these age- related microbiota changes represents a potential strategy for reducing age-associated inflammation and the accompanying morbidity.
715 citations
TL;DR: The findings suggest the value of models that include a wide range of health and health-determinant variables, and affirm the importance of looking more closely at gender differences in health, are affirm.
715 citations
TL;DR: The ENIGMA Consortium has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected.
Abstract: The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
713 citations
Hamilton Health Sciences1, University of Western Ontario2, Royal Melbourne Hospital3, St. John's Medical College4, McMaster University5, University of Basel6, Université catholique de Louvain7, Cayetano Heredia University8, Medical University of Vienna9, University of Manitoba10, University of Alberta11, University of Oxford12, University of Sydney13
TL;DR: Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of a composite of death or nonfatal myocardial infarction but increased the risk of major bleeding.
Abstract: The primary outcome occurred in 351 of 4998 patients (7.0%) in the aspirin group and in 355 of 5012 patients (7.1%) in the placebo group (hazard ratio in the aspirin group, 0.99; 95% confidence interval [CI], 0.86 to 1.15; P = 0.92). Major bleeding was more common in the aspirin group than in the placebo group (230 patients [4.6%] vs. 188 patients [3.8%]; hazard ratio, 1.23; 95% CI, 1.01, to 1.49; P = 0.04). The primary and secondary outcome results were similar in the two aspirin strata. Conclusions Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of a composite of death or nonfatal myocardial infarction but increased the risk of major bleeding. (Funded by the Canadian Institutes of Health Research and others; POISE-2 ClinicalTrials.gov number, NCT01082874.)
713 citations
Authors
Showing all 41721 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Salim Yusuf | 231 | 1439 | 252912 |
| Gordon H. Guyatt | 231 | 1620 | 228631 |
| Simon D. M. White | 189 | 795 | 231645 |
| George Efstathiou | 187 | 637 | 156228 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Terrie E. Moffitt | 182 | 594 | 150609 |
| John J.V. McMurray | 178 | 1389 | 184502 |
| Jasvinder A. Singh | 176 | 2382 | 223370 |
| Deborah J. Cook | 173 | 907 | 148928 |
| Andrew P. McMahon | 162 | 415 | 90650 |
| Jack Hirsh | 146 | 734 | 86332 |
| Holger J. Schünemann | 141 | 810 | 113169 |
| John A. Peacock | 140 | 565 | 125416 |
| David Price | 138 | 1687 | 93535 |
| Graeme J. Hankey | 137 | 844 | 143373 |