Institution
McMaster University
Education•Hamilton, Ontario, Canada•
About: McMaster University is a education organization based out in Hamilton, Ontario, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 41361 authors who have published 101269 publications receiving 4251422 citations.
Papers published on a yearly basis
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TL;DR: The results indicate that it is the surface properties, hydrophobicity, surface charge and composition of EPS, of sludge, rather than the quantity of EPS that govern bioflocculation, and in contrast, the EPS content is more important in controlling the settleability of sludges.
684 citations
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McGill University Health Centre1, Foothills Medical Centre2, University of Calgary3, University of British Columbia4, McGill University5, University of Western Ontario6, Université du Québec à Trois-Rivières7, McMaster University8, Concordia University Wisconsin9, St. Michael's Hospital10, Ottawa Hospital Research Institute11, Memorial University of Newfoundland12, Montreal General Hospital13, Université de Montréal14, University of Saskatchewan15, Heart and Stroke Foundation of Canada16, Dalhousie University17, Hôpital Maisonneuve-Rosemont18, University of Toronto19, Laval University20, University of Alberta21, Université de Sherbrooke22, University Health Network23, University of Manitoba24, University of Ottawa25, Université du Québec à Montréal26, Centre for Addiction and Mental Health27, Canadian Stroke Network28, Department of National Defence29, Northern Ontario School of Medicine30
TL;DR: The Canadian Hypertension Education Program reviews the hypertension literature annually and provides detailed recommendations regarding hypertension diagnosis, assessment, prevention, and treatment, and 4 new recommendations were added and 2 existing recommendations were modified this year.
683 citations
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TL;DR: It is recommended that in cases where the variables can be separated into meaningful blocks, the standard PCA and PLS methods be used to build the models and then the weights and loadings of the individual blocks and super block and the percentage variation explained in each block be calculated from the results.
Abstract: Multiblock and hierarchical PCA and PLS methods have been proposed in the recent literature in order to improve the interpretability of multivariate models. They have been used in cases where the number of variables is large and additional information is available for blocking the variables into conceptually meaningful blocks. In this paper we compare these methods from a theoretical or algorithmic viewpoint using a common notation and illustrate their differences with several case studies. Undesirable properties of some of these methods, such as convergence problems or loss of data information due to deflation procedures, are pointed out and corrected where possible. It is shown that the objective function of the hierarchical PCA and hierarchical PLS methods is not clear and the corresponding algorithms may converge to different solutions depending on the initial guess of the super score. It is also shown that the results of consensus PCA (CPCA) and multiblock PLS (MBPLS) can be calculated from the standard PCA and PLS methods when the same variable scalings are applied for these methods. The standard PCA and PLS methods require less computation and give better estimation of the scores in the case of missing data. It is therefore recommended that in cases where the variables can be separated into meaningful blocks, the standard PCA and PLS methods be used to build the models and then the weights and loadings of the individual blocks and super block and the percentage variation explained in each block be calculated from the results. © 1998 John Wiley & Sons, Ltd.
682 citations
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Tufts University1, Karolinska University Hospital2, University of Texas MD Anderson Cancer Center3, Universitaire Ziekenhuizen Leuven4, City of Hope National Medical Center5, McMaster University6, Jichi Medical University7, University of Chicago8, Fred Hutchinson Cancer Research Center9, University of Pennsylvania10, Merck & Co.11, University of Würzburg12
TL;DR: Letermovir prophylaxis resulted in a significantly lower risk of clinically significant CMV infection than placebo, and the frequency and severity of adverse events were similar in the two groups overall.
Abstract: BackgroundCytomegalovirus (CMV) infection remains a common complication after allogeneic hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the CMV–terminase complex. MethodsIn this phase 3, double-blind trial, we randomly assigned CMV-seropositive transplant recipients, 18 years of age or older, in a 2:1 ratio to receive letermovir or placebo, administered orally or intravenously, through week 14 after transplantation; randomization was stratified according to trial site and CMV disease risk. Letermovir was administered at a dose of 480 mg per day (or 240 mg per day in patients taking cyclosporine). Patients in whom clinically significant CMV infection (CMV disease or CMV viremia leading to preemptive treatment) developed discontinued the trial regimen and received anti-CMV treatment. The primary end point was the proportion of patients, among patients without detectable CMV DNA at randomization, who had clinically significant CMV infection through week 24 after transplanta...
682 citations
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TL;DR: Probiotics appear to be efficacious in IBS, but the magnitude of benefit and the most effective species and strain are uncertain.
Abstract: Introduction Probiotics may benefit irritable bowel syndrome (IBS) symptoms, but randomised controlled trials (RCTs) have been conflicting; therefore a systematic review was conducted. Methods MEDLINE (1966 to May 2008), EMBASE (1988 to May 2008) and the Cochrane Controlled Trials Register (2008) electronic databases were searched, as were abstracts from DDW (Digestive Diseases Week) and UEGW (United European Gastroenterology Week), and authors were contacted for extra information. Only parallel group RCTs with at least 1 week of treatment comparing probiotics with placebo or no treatment in adults with IBS according to any acceptable definition were included. Studies had to provide improvement in abdominal pain or global IBS symptoms as an outcome. Eligibility assessment and data extraction were performed by two independent researchers. Data were synthesised using relative risk (RR) of symptoms not improving for dichotomous data and standardised mean difference (SMD) for continuous data using random effects models. Results 19 RCTs (18 papers) in 1650 patients with IBS were identified. Trial quality was generally good, with nine reporting adequate methods of randomisation and six a method of concealment of allocation. There were 10 RCTs involving 918 patients providing outcomes as a dichotomous variable. Probiotics were statistically significantly better than placebo (RR of IBS not improving=0.71; 95% CI 0.57 to 0.88) with a number needed to treat (NNT)=4 (95% CI 3 to 12.5). There was significant heterogeneity (χ 2 =28.3, p=0.001, I 2 =68%) and possible funnel plot asymmetry. Fifteen trials assessing 1351 patients reported on improvement in IBS score as a continuous outcome (SMD=−0.34; 95% CI −0.60 to −0.07). There was statistically significant heterogeneity (χ 2 =67.04, p 2 =79%), but this was explained by one outlying trial. Conclusion Probiotics appear to be efficacious in IBS, but the magnitude of benefit and the most effective species and strain are uncertain.
682 citations
Authors
Showing all 41721 results
Name | H-index | Papers | Citations |
---|---|---|---|
Salim Yusuf | 231 | 1439 | 252912 |
Gordon H. Guyatt | 231 | 1620 | 228631 |
Simon D. M. White | 189 | 795 | 231645 |
George Efstathiou | 187 | 637 | 156228 |
Stuart H. Orkin | 186 | 715 | 112182 |
Terrie E. Moffitt | 182 | 594 | 150609 |
John J.V. McMurray | 178 | 1389 | 184502 |
Jasvinder A. Singh | 176 | 2382 | 223370 |
Deborah J. Cook | 173 | 907 | 148928 |
Andrew P. McMahon | 162 | 415 | 90650 |
Jack Hirsh | 146 | 734 | 86332 |
Holger J. Schünemann | 141 | 810 | 113169 |
John A. Peacock | 140 | 565 | 125416 |
David Price | 138 | 1687 | 93535 |
Graeme J. Hankey | 137 | 844 | 143373 |