scispace - formally typeset
Search or ask a question
Institution

McMaster University

EducationHamilton, Ontario, Canada
About: McMaster University is a education organization based out in Hamilton, Ontario, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 41361 authors who have published 101269 publications receiving 4251422 citations.


Papers
More filters
Journal ArticleDOI
05 Jan 1994-JAMA
TL;DR: A general internist is asked to see a 65-year-old man with controlled hypertension and a 6-month history of atrial fibrillation resistant to cardioversion, who has no evidence for valvular or coronary heart disease, and who shares concerns about the benefits of long-term anticoagulant therapy.
Abstract: CLINICAL SCENARIO You are a general internist who is asked to see a 65-year-old man with controlled hypertension and a 6-month history of atrial fibrillation resistant to cardioversion. Although he has no evidence for valvular or coronary heart disease, the family physician who referred him to you wants your advice on whether the benefits of long-term anticoagulants (to reduce the risk of embolic stroke) outweigh their risks (of hemorrhage from anticoagulant therapy). The patient shares these concerns and doesn't want to receive a treatment that would do more harm than good. You know that there have been randomized trials of warfarin for nonvalvular atrial fibrillation and decide that you'd better review one of them.

678 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present the ESTIMATE checklist, which includes a list of questions to consider when justifying the choice of analysis method, describing the analysis, and interpreting the results.

678 citations

Journal ArticleDOI
TL;DR: The green and yellow luminescence centres in ZnO and Mn-doped ZnOs are investigated in this article, and it seems that a VZn · V0 divacancy exists, and that luminecence is due to interstitial zinc and oxygen.

678 citations

Journal ArticleDOI
TL;DR: Cancer and its treatments are well‐recognized risk factors for venous thromboembolism (VTE), and patients with cancer and acute VTE who take anticoagulants for an extended period are at increased risk of recurrent VTE and bleeding.
Abstract: Cancer and its treatments are well-recognized risk factors for venous thromboembolism (VTE). Evidence suggests that the absolute risk depends on the tumor type, the stage or extent of the cancer, and treatment with antineoplastic agents. Furthermore, age, surgery, immobilization, and other comorbid features will also influence the overall likelihood of thrombotic complications, as they do in patients without cancer. The role of hereditary thrombophilia in patients with cancer and thrombosis is still unclear, and screening for this condition in cancer patients is not indicated. The most common malignancies associated with thrombosis are those of the breast, colon, and lung, reflecting the prevalence of these malignancies in the general population. When adjusted for disease prevalence, the cancers most strongly associated with thrombotic complications are those of the pancreas, ovary, and brain. Idiopathic thrombosis can be the first manifestation of an occult malignancy. However, intensive screening for cancer in patients with VTE often does not improve survival and is not generally warranted. Independently of the timing of cancer diagnosis (before or after the VTE), the life expectancy of cancer patients with VTE is relatively short, because of both deaths from recurrent VTE and the cancer itself. Patients with cancer and acute VTE who take anticoagulants for an extended period are at increased risk of recurrent VTE and bleeding. A recent randomized trial, the Randomized Comparison of Low Molecular Weight Heparin versus Oral Anticoagulant Therapy for Long-Term Anticoagulation in Cancer Patients with Venous Thromboembolism (CLOT) study, showed that low molecular weight heparin may be a better treatment option for this group of patients. The antineoplastic effects of anticoagulants are being actively investigated with promising preliminary results.

678 citations

Journal ArticleDOI
TL;DR: The Inflammatory Bowel Disease Questionnaire is a valid reliable assessment tool that reflects important changes in the health status of patients with IBD and should be used in future clinical trials in IBD.

677 citations


Authors

Showing all 41721 results

NameH-indexPapersCitations
Salim Yusuf2311439252912
Gordon H. Guyatt2311620228631
Simon D. M. White189795231645
George Efstathiou187637156228
Stuart H. Orkin186715112182
Terrie E. Moffitt182594150609
John J.V. McMurray1781389184502
Jasvinder A. Singh1762382223370
Deborah J. Cook173907148928
Andrew P. McMahon16241590650
Jack Hirsh14673486332
Holger J. Schünemann141810113169
John A. Peacock140565125416
David Price138168793535
Graeme J. Hankey137844143373
Network Information
Related Institutions (5)
University of Toronto
294.9K papers, 13.5M citations

98% related

University of Pittsburgh
201K papers, 9.6M citations

94% related

University of Minnesota
257.9K papers, 11.9M citations

93% related

University of California, San Diego
204.5K papers, 12.3M citations

93% related

Northwestern University
188.8K papers, 9.4M citations

93% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023168
2022521
20216,351
20205,747
20195,093
20184,604