Institution
McMaster University
Education•Hamilton, Ontario, Canada•
About: McMaster University is a education organization based out in Hamilton, Ontario, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 41361 authors who have published 101269 publications receiving 4251422 citations.
Papers published on a yearly basis
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TL;DR: A strategy of initial CABG surgery is associated with lower mortality than one of medical management with delayed surgery if necessary, especially in high-risk and medium- risk patients with stable coronary heart disease, and in low-risk patients, the limited data show a non-significant trend towards greater mortality with CABGs.
1,984 citations
TL;DR: This article introduces a 20-part series providing guidance for the use of GRADE methodology that will appear in the Journal of Clinical Epidemiology.
1,975 citations
TL;DR: Target metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments are reported and show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.
Abstract: The discovery of antibiotics more than 70 years ago initiated a period of drug innovation and implementation in human and animal health and agriculture. These discoveries were tempered in all cases by the emergence of resistant microbes. This history has been interpreted to mean that antibiotic resistance in pathogenic bacteria is a modern phenomenon; this view is reinforced by the fact that collections of microbes that predate the antibiotic era are highly susceptible to antibiotics. Here we report targeted metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments and the identification of a highly diverse collection of genes encoding resistance to β-lactam, tetracycline and glycopeptide antibiotics. Structure and function studies on the complete vancomycin resistance element VanA confirmed its similarity to modern variants. These results show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.
1,973 citations
TL;DR: You are back where you were in the previous article1 on diagnostic tests: in the library studying an article that will guide you in interpreting ventilation-perfusion (V/Q) lung scans.
Abstract: You are back where we put you in the previous article1 on diagnostic tests in this series on how to use the medical literature: in the library studying an article that will guide you in interpreting ventilation-perfusion (V/Q) lung scans. Using the criteria in Table 1, you have decided that the Prospective Investigation of Pulmonary Diagnosis (PIOPED) study2 will provide you with valid information. Just then, another physician
1,963 citations
TL;DR: Three types of configural processing are distinguished: detecting the first-order relations that define faces, holistic processing (glueing the features together into a gestalt), and processing second- order relations (i.e. the spacing among features).
1,949 citations
Authors
Showing all 41721 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Salim Yusuf | 231 | 1439 | 252912 |
| Gordon H. Guyatt | 231 | 1620 | 228631 |
| Simon D. M. White | 189 | 795 | 231645 |
| George Efstathiou | 187 | 637 | 156228 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Terrie E. Moffitt | 182 | 594 | 150609 |
| John J.V. McMurray | 178 | 1389 | 184502 |
| Jasvinder A. Singh | 176 | 2382 | 223370 |
| Deborah J. Cook | 173 | 907 | 148928 |
| Andrew P. McMahon | 162 | 415 | 90650 |
| Jack Hirsh | 146 | 734 | 86332 |
| Holger J. Schünemann | 141 | 810 | 113169 |
| John A. Peacock | 140 | 565 | 125416 |
| David Price | 138 | 1687 | 93535 |
| Graeme J. Hankey | 137 | 844 | 143373 |