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Institution

Medical Research Council

GovernmentLondon, United Kingdom
About: Medical Research Council is a government organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Malaria. The organization has 16430 authors who have published 19150 publications receiving 1475494 citations.
Topics: Population, Malaria, Poison control, Gene, Antigen


Papers
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Journal ArticleDOI
TL;DR: Telomere length is longer in females than males, although this difference was not universally found in studies that did not use Southern blot methods, and further research on explanations for the methodological differences is required.

370 citations

Journal ArticleDOI
TL;DR: The Piper rhythm in muscle may be driven by a comparable oscillatory activity in the contralateral motor cortex, which can be picked up in several types of movement and seems distinct from the 20- to 30-Hz rhythmicity recorded during weak sustained contractions.
Abstract: Brown, Peter, Stephan Salenius, John C. Rothwell, and Riitta Hari. Cortical correlate of the Piper rhythm in humans. J. Neurophysiol. 80: 2911–2917, 1998. The electromyogram (EMG) of healthy humans...

369 citations

Journal ArticleDOI
Louise V. Wain1, Germaine C. Verwoert2, Paul F. O'Reilly3, Gang Shi4  +226 moreInstitutions (70)
TL;DR: Findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP, as well as two new MAP loci associated with both of these traits.
Abstract: Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.

369 citations

Journal ArticleDOI
TL;DR: The interconnections and relations of these neurones to dorsal horn projection neurones are considered in the light of the reported analgesic properties of a number of these substances when applied directly to the spinal cord.

368 citations

Journal ArticleDOI
TL;DR: The results suggest that children of all ages with clinical features of HIV infection should receive co-trimoxazole prophylaxis in resource-poor settings, irrespective of local resistance to this drug.

368 citations


Authors

Showing all 16441 results

NameH-indexPapersCitations
Shizuo Akira2611308320561
Trevor W. Robbins2311137164437
Richard A. Flavell2311328205119
George Davey Smith2242540248373
Nicholas J. Wareham2121657204896
Cyrus Cooper2041869206782
Martin White1962038232387
Frank E. Speizer193636135891
Michael Rutter188676151592
Richard Peto183683231434
Terrie E. Moffitt182594150609
Kay-Tee Khaw1741389138782
Chris D. Frith173524130472
Phillip A. Sharp172614117126
Avshalom Caspi170524113583
Network Information
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20236
20229
2021262
2020243
2019231
2018309