Institution
Medical Research Council
Government•London, United Kingdom•
About: Medical Research Council is a government organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Malaria. The organization has 16430 authors who have published 19150 publications receiving 1475494 citations.
Papers published on a yearly basis
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University of Helsinki1, National Institutes of Health2, Wellcome Trust Centre for Human Genetics3, University of Tartu4, University of Ferrara5, University Medical Center Groningen6, Amgen7, Karolinska Institutet8, Uppsala University9, VU University Amsterdam10, Erasmus University Rotterdam11, Lund University12, Leiden University Medical Center13, National Institute for Health Research14, University of Lübeck15, Medical Research Council16, Technische Universität München17, University of Tampere18, Steno Diabetes Center19, Ludwig Maximilian University of Munich20, Harvard University21, Massachusetts Institute of Technology22, European Bioinformatics Institute23, University of Leicester24, Turku University Hospital25, Uppsala University Hospital26, Erasmus University Medical Center27, University College London28, University of Turku29, University of Oxford30, University of Iceland31, Minerva Foundation Institute for Medical Research32, University of Liverpool33, Imperial College London34, Wellcome Trust Sanger Institute35
TL;DR: Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, association to lipid traits in 93 loci is identified, including 79 previously identified loci with new lead SNPs and 10 new loci, including 15 locu with a low-frequency lead SNP and 10 loco with a missense lead SNP.
Abstract: Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, including 79 previously identified loci with new lead SNPs and 10 new loci, 15 loci with a low-frequency lead SNP and 10 loci with a missense lead SNP, and 2 loci with an accumulation of rare variants. In six loci, SNPs with established function in lipid genetics (CELSR2, GCKR, LIPC and APOE) or candidate missense mutations with predicted damaging function (CD300LG and TM6SF2) explained the locus associations. The low-frequency variants increased the proportion of variance explained, particularly for low-density lipoprotein cholesterol and total cholesterol. Altogether, our results highlight the impact of low-frequency variants in complex traits and show that imputation offers a cost-effective alternative to resequencing.
279 citations
TL;DR: A double-blind randomized trial has been conducted in which patients with objectively established acute symptomatic pulmonary embolism who were receiving heparin were allocated to either a 2-minute infusion of rt-PA at a dose of 0.6 mg/kg or saline placebo, suggesting that a bolus regimen of rT-PA produces accelerated thrombolysis and provides an alternative and convenient approach to thROMbolytic therapy in patients with pulmonary emblism.
279 citations
TL;DR: The abilities of slurries of human faecal bacteria to ferment 20 different amino acids were investigated in batch culture incubations, and acetate, propionate and butyrate were formed from cysteine, whereas the main products of methionine metabolism were propionates andbutyrate.
279 citations
Patent•
05 Dec 1994TL;DR: In this article, isolated nucleic acid constructs consisting essentially of a sequence of nucleotides encoding a self-splicing intron with a site-specific recombination sequence within the intron, for use in creation of constructs for expression of peptides or polypeptides, are also provided.
Abstract: DNA constructs comprise a first exon sequence of nucleotides encoding a first peptide or polypeptide, a second exon sequence of nucleotides encoding a second peptide or polypeptide and a third sequence of nucleotides between the first and second sequences encoding a heterologous intron, for example that of Tetrahymena thermophila nuclear pre-rRNA, between RNA splice sites and a site-specific recombination sequence, such as loxP, within the intron, the exons together encoding a product peptide or polypeptide. Such constructs are of use in methods of production of peptides or polypeptides, transcription leading to splicing out of the intron enabling translation of a single chain product peptide or polypeptide. Isolated nucleic acid constructs consisting essentially of a sequence of nucleotides encoding a self-splicing intron with a site-specific recombination sequence within the intron, for use in creation of constructs for expression of peptides or polypeptides, are also provided.
279 citations
TL;DR: A clear definition of the burden concept is offered, an exposition of the criteria for evaluating rating scales to measure the concept, a review of major rating scales of burden, and some suggestions for improvements in methodology which are urgently required are offered.
Abstract: The gradual shift towards non-institutional treatment for severe and chronic psychiatric illnesses has been accompanied by a recognition of potentially harmful effects ('burden') upon the patient's caregivers. This paper aims to provide a framework for the development of further research into the burden of 'community care' by offering a clear definition of the burden concept, an exposition of the criteria for evaluating rating scales to measure the concept, a review of major rating scales of burden, and some suggestions for improvements in methodology which are urgently required.
278 citations
Authors
Showing all 16441 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Shizuo Akira | 261 | 1308 | 320561 |
| Trevor W. Robbins | 231 | 1137 | 164437 |
| Richard A. Flavell | 231 | 1328 | 205119 |
| George Davey Smith | 224 | 2540 | 248373 |
| Nicholas J. Wareham | 212 | 1657 | 204896 |
| Cyrus Cooper | 204 | 1869 | 206782 |
| Martin White | 196 | 2038 | 232387 |
| Frank E. Speizer | 193 | 636 | 135891 |
| Michael Rutter | 188 | 676 | 151592 |
| Richard Peto | 183 | 683 | 231434 |
| Terrie E. Moffitt | 182 | 594 | 150609 |
| Kay-Tee Khaw | 174 | 1389 | 138782 |
| Chris D. Frith | 173 | 524 | 130472 |
| Phillip A. Sharp | 172 | 614 | 117126 |
| Avshalom Caspi | 170 | 524 | 113583 |