Institution
Medical Research Council
Government•London, United Kingdom•
About: Medical Research Council is a government organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Malaria. The organization has 16430 authors who have published 19150 publications receiving 1475494 citations.
Papers published on a yearly basis
Papers
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TL;DR: Results indicate that any pattern of methylated and unmethylated paired CpGs in the genome of a cell will be inherited by descendants of that cell.
271 citations
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TL;DR: Xenopus laevis homolog (xRTS) of the RECQL4 helicase mutated in Rothmund-Thomson syndrome functions after pre-RC formation to promote loading of replication factors at origins, a previously unrecognized activity necessary for initiation.
271 citations
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TL;DR: It is shown that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability, which enables a single progenitor population to both maintain and repair tissue without the need for a “reserve” slow-cycling stem cell pool.
Abstract: Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability. In response to challenge with all-trans retinoic acid (atRA), the balance of daughter cell fate is unaltered, but the rate of cell division increases. However, after wounding, cells reversibly switch to producing an excess of proliferating daughters until the wound has closed. Such fate-switching enables a single progenitor population to both maintain and repair tissue without the need for a "reserve" slow-cycling stem cell pool.
271 citations
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TL;DR: A chronic relapsing form of experimental allergic encephalomyelitis was induced by single sensitization of immature strain 13 and Hartley guinea pigs and opened new avenues for the study of immunological mechanisms governing remissions and exacerbations in multiple sclerosis.
Abstract: A chronic relapsing form of experimental allergic encephalomyelitis was induced by single sensitization of immature strain 13 and Hartley guinea pigs. Clinically, the disease was characterized by remissions and relapses. Recent and old demyelinating plaques, which are the two characteristic features of multiple sclerosis lesions, were also present. The model described opens new avenues for the study of immunological mechanisms governing remissions and exacerbations in multiple sclerosis and offers new opportunities for evaluating the efficacy of drugs for its treatment.
270 citations
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TL;DR: Several interventions with sufficient evidence to recommend implementation in health systems are identified, including periconceptional folic acid supplementation or fortification, prevention of malaria, and improved detection and management of syphilis during pregnancy in endemic areas.
270 citations
Authors
Showing all 16441 results
Name | H-index | Papers | Citations |
---|---|---|---|
Shizuo Akira | 261 | 1308 | 320561 |
Trevor W. Robbins | 231 | 1137 | 164437 |
Richard A. Flavell | 231 | 1328 | 205119 |
George Davey Smith | 224 | 2540 | 248373 |
Nicholas J. Wareham | 212 | 1657 | 204896 |
Cyrus Cooper | 204 | 1869 | 206782 |
Martin White | 196 | 2038 | 232387 |
Frank E. Speizer | 193 | 636 | 135891 |
Michael Rutter | 188 | 676 | 151592 |
Richard Peto | 183 | 683 | 231434 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Chris D. Frith | 173 | 524 | 130472 |
Phillip A. Sharp | 172 | 614 | 117126 |
Avshalom Caspi | 170 | 524 | 113583 |