scispace - formally typeset
Search or ask a question
Institution

Medical Research Council

GovernmentLondon, United Kingdom
About: Medical Research Council is a government organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Malaria. The organization has 16430 authors who have published 19150 publications receiving 1475494 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: Results indicate that any pattern of methylated and unmethylated paired CpGs in the genome of a cell will be inherited by descendants of that cell.

271 citations

Journal ArticleDOI
17 Jun 2005-Cell
TL;DR: Xenopus laevis homolog (xRTS) of the RECQL4 helicase mutated in Rothmund-Thomson syndrome functions after pre-RC formation to promote loading of replication factors at origins, a previously unrecognized activity necessary for initiation.

271 citations

Journal ArticleDOI
31 Aug 2012-Science
TL;DR: It is shown that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability, which enables a single progenitor population to both maintain and repair tissue without the need for a “reserve” slow-cycling stem cell pool.
Abstract: Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability. In response to challenge with all-trans retinoic acid (atRA), the balance of daughter cell fate is unaltered, but the rate of cell division increases. However, after wounding, cells reversibly switch to producing an excess of proliferating daughters until the wound has closed. Such fate-switching enables a single progenitor population to both maintain and repair tissue without the need for a "reserve" slow-cycling stem cell pool.

271 citations

Journal ArticleDOI
TL;DR: A chronic relapsing form of experimental allergic encephalomyelitis was induced by single sensitization of immature strain 13 and Hartley guinea pigs and opened new avenues for the study of immunological mechanisms governing remissions and exacerbations in multiple sclerosis.
Abstract: A chronic relapsing form of experimental allergic encephalomyelitis was induced by single sensitization of immature strain 13 and Hartley guinea pigs. Clinically, the disease was characterized by remissions and relapses. Recent and old demyelinating plaques, which are the two characteristic features of multiple sclerosis lesions, were also present. The model described opens new avenues for the study of immunological mechanisms governing remissions and exacerbations in multiple sclerosis and offers new opportunities for evaluating the efficacy of drugs for its treatment.

270 citations

Journal ArticleDOI
TL;DR: Several interventions with sufficient evidence to recommend implementation in health systems are identified, including periconceptional folic acid supplementation or fortification, prevention of malaria, and improved detection and management of syphilis during pregnancy in endemic areas.

270 citations


Authors

Showing all 16441 results

NameH-indexPapersCitations
Shizuo Akira2611308320561
Trevor W. Robbins2311137164437
Richard A. Flavell2311328205119
George Davey Smith2242540248373
Nicholas J. Wareham2121657204896
Cyrus Cooper2041869206782
Martin White1962038232387
Frank E. Speizer193636135891
Michael Rutter188676151592
Richard Peto183683231434
Terrie E. Moffitt182594150609
Kay-Tee Khaw1741389138782
Chris D. Frith173524130472
Phillip A. Sharp172614117126
Avshalom Caspi170524113583
Network Information
Related Institutions (5)
National Institutes of Health
297.8K papers, 21.3M citations

94% related

University of California, San Francisco
186.2K papers, 12M citations

92% related

Karolinska Institutet
121.1K papers, 6M citations

92% related

French Institute of Health and Medical Research
174.2K papers, 8.3M citations

92% related

Johns Hopkins University School of Medicine
79.2K papers, 4.7M citations

92% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20236
20229
2021262
2020243
2019231
2018309