Medical Research Council

About: Medical Research Council is a government organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Malaria. The organization has 16430 authors who have published 19150 publications receiving 1475494 citations.

Production of anti-self antibodies from antibody segment repertoires and displayed on phage

Abstract: Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self-antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface a member of a specific binding pair which is an antibody or antibody fragment, and each rgdp containing nucleic acid sequence derived from a species of mammal. The nucleic acid sequence in each rgdp encodes a polypeptide chain which is a component part of the sbp member displayed at the surface of that rgdp. Anti-self antibody fragments are selected by binding with a self antigen from the said species of mammal. The displayed antibody fragments may be scFv, Fd, Fab or any other fragment which has the capability of binding antigen. Nucleic acid libraries used may be derived from a rearranged V-gene sequences of unimmunised mammal. Synthetic or artificial libraries are described and shown to be useful.

Mental models: towards a cognitive science of language, inference, and consciousness

Abstract: Mental Models offers nothing less than a unified theory of the major properties of mind: comprehension, inference, and consciousness. In spirited and graceful prose, Johnson-Laird argues that we apprehend the world by building inner mental replicas of the relations among objects and events that concern us. The mind is essentially a model-building device that can itself be modeled on a digital computer. This book provides both a blueprint for building such a model and numerous important illustrations of how to do it. In several key areas of cognition, Johnson-Laird shows how an explanation based on mental modeling is clearly superior to previous theory. For example, he argues compellingly that deductive reasoning does not take place by tacitly applying the rules of logic, but by mentally manipulating models of the states of affairs from which inferences are drawn. Similarly, linguistic comprehension is best understood not as a matter of applying inference rules to propositions derived from sentences, but rather as the mind's effort to construct and update a model of the situation described by a text or a discourse. Most provocative, perhaps, is Johnson-Laird's theory of consciousness: the mind's necessarily incomplete model of itself allows only a partial control over the many unconscious and parallel processes of cognition. This an extraordinarily rich book, providing a coherent account of much recent experimental work in cognitive psychology, along with lucid explanations of relevant theory in linguistics, computer science, and philosophy Not since Miller, Galanter, and Pribram's classic Plans and the Structure of Behavior has a book in cognitive science combined such sweep, style, and good sense. Like its distinguished predecessor, Mental Models may well serve to fix a point of view for a generation. (http://books.google.fr/books?id=FS3zSKAfLGMC&printsec=frontcover&hl=fr#v=onepage&q&f=false)

Acoustic confusions in immediate memory.

Abstract: Sequences of 6 letters of the alphabet were visually presented for immediate recall to 387 subjects. Errors showed a systematic relationship to original stimuli. This is held to meet a requirement of the decay theory of immediate memory. The same letter vocabulary was used in a test in which subjects were required to identify the letters spoken against a white noise background. A highly significant correlation was found between letters which confused in the listening test, and letters which confused in recall. The role of neurological noise in recall is discussed in relation to these results. It is further argued that information theory is inadequate to explain the memory span, since the nature of the stimulus set, which can be defined quantitatively, as well as the information per item, is likely to be a determining factor.