Medical Research Council

About: Medical Research Council is a government organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Malaria. The organization has 16430 authors who have published 19150 publications receiving 1475494 citations.

Designing and evaluating complex interventions to improve health care

Abstract: Determining the effectiveness of complex interventions can be difficult and time consuming. Neil C Campbell and colleagues explain the importance of ground work in getting usable results

General Nature of the Genetic Code for Proteins

Abstract: In this paper Crick, Brenner, and their collaborators described a very elegant series of genetic experiments by which they proved that the genetic code for protein was a triplet code. They used an acridine dye, proflavin, to induce mutations in a specific, well-studied gene of a virus, a so-called bacteriophage, that attacked the bacterium Escherichia coli. The effect of proflavin was to either eliminate a single nucleotide from the gene or to add a nucleotide, each of which had the effect of rendering the virus incapable of synthesizing a particular protein. After a sequence of three such additions or deletions, the nucleotide sequence of the gene once again come into frame, and synthesis of the protein resumed. This proved that the nucleotide sequence which carried the genetic information was to be read three (or, less likely, six) nucleotides at a time proceeding from a fixed starting point.