Institution
Medical Research Council
Government•London, United Kingdom•
About: Medical Research Council is a government organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Malaria. The organization has 16430 authors who have published 19150 publications receiving 1475494 citations.
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TL;DR: The structure of a tRNA has been determined by isomorphous replacement but the interactions which maintain the tertiary structure are of a novel type and this model differs significantly from one which has recently been proposed.
Abstract: The structure of a tRNA has been determined by isomorphous replacement. Some of the interactions which maintain the tertiary structure are of a novel type. Our model differs significantly from one which has recently been proposed.
901 citations
TL;DR: In rectal cancer, the plane of surgery achieved is an important prognostic factor for local recurrence, and both a negative circumferential resection margin and a superior plane of Surgery achieved were associated with lowLocal recurrence rates.
897 citations
University College London1, University of Cambridge2, University of Cologne3, Leiden University4, Utrecht University5, National Institutes of Health6, University of Pennsylvania7, University of Glasgow8, University of Edinburgh9, Mayo Clinic10, University of London11, University of Bristol12, Cardiff University13, University of Oxford14, University of Ioannina15, University of Hamburg16, Lithuanian University of Health Sciences17, Jagiellonian University18, Russian Academy19, Karolinska Institutet20, Memorial Hospital of South Bend21, University of Groningen22, MedStar Washington Hospital Center23, Swansea University24, Brown University25, University of Iowa26, Harvard University27, University of Exeter28, University of North Carolina at Chapel Hill29, Boston University30, Medical Research Council31, University of California, San Diego32, University of Mississippi33, Fred Hutchinson Cancer Research Center34
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
891 citations
TL;DR: The extent to which the tests predicted the patients' everyday life problems was significantly predictive of at least some of the behavioral and cognitive deficits reported by patients' carers, supporting the conclusions that different tests measure different cognitive processes and that there may be limits to the fractionation of the executive system.
Abstract: Ninety-two mixed etiology neurological patients and 216 control participants were assessed on a range of neuropsychological tests, including 10 neuropsychological measures of executive function derived from 6 different tests. People who knew the patients well (relatives or carers) completed a questionnaire about the patient's dysexecutive problems in everyday life, and this paper reports the extent to which the tests predicted the patients' everyday life problems. All of the tests were significantly predictive of at least some of the behavioral and cognitive deficits reported by patients' carers. However, factor analysis of the patients' dysexecutive symptoms suggested a fractionation of the dysexecutive syndrome, with neuropsychological tests loading differentially on 3 underlying cognitive factors (Inhibition, Intentionality, and Executive Memory), supporting the conclusions that different tests measure different cognitive processes, and that there may be limits to the fractionation of the executive system.
888 citations
01 Apr 1994
886 citations
Authors
Showing all 16441 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Shizuo Akira | 261 | 1308 | 320561 |
| Trevor W. Robbins | 231 | 1137 | 164437 |
| Richard A. Flavell | 231 | 1328 | 205119 |
| George Davey Smith | 224 | 2540 | 248373 |
| Nicholas J. Wareham | 212 | 1657 | 204896 |
| Cyrus Cooper | 204 | 1869 | 206782 |
| Martin White | 196 | 2038 | 232387 |
| Frank E. Speizer | 193 | 636 | 135891 |
| Michael Rutter | 188 | 676 | 151592 |
| Richard Peto | 183 | 683 | 231434 |
| Terrie E. Moffitt | 182 | 594 | 150609 |
| Kay-Tee Khaw | 174 | 1389 | 138782 |
| Chris D. Frith | 173 | 524 | 130472 |
| Phillip A. Sharp | 172 | 614 | 117126 |
| Avshalom Caspi | 170 | 524 | 113583 |