Institution
Medical Research Council
Government•London, United Kingdom•
About: Medical Research Council is a government organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Malaria. The organization has 16430 authors who have published 19150 publications receiving 1475494 citations.
Topics: Population, Malaria, Poison control, Gene, Antigen
Papers published on a yearly basis
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TL;DR: In this article, the authors investigated the effect of the COVID-19 pandemic on admissions of patients with acute coronary syndromes in England and evaluated whether in-hospital management of patients has been affected.
470 citations
TL;DR: The subunit composition of bovine complex I is established, a complex of 45 different proteins plus non-covalently bound FMN and eight iron-sulfur clusters and shown to be a C-terminal fragment of subunit SGDH arising from a specific peptide bond cleavage between Ile-55 and Pro-56 during the electrospray ionization process.
469 citations
TL;DR: In this paper, the authors present the findings of a qualitative study conducted among Xhosa-speaking adolescent women in South Africa which revealed male violent and coercive practices to dominate their sexual relationships.
469 citations
Wellcome Trust Centre for Human Genetics1, University of Oxford2, Wellcome Trust Sanger Institute3, University of Cambridge4, Nuffield Orthopaedic Centre5, University of Queensland6, University of Leicester7, Queen Mary University of London8, University of Leeds9, Peninsula College of Medicine and Dentistry10, King's College London11, University College London12, Western General Hospital13, University of Manchester14, Medical Research Council15, National Health Service16, Wellcome Trust17, National Institute for Health Research18, Churchill Hospital19
TL;DR: In this paper, the authors defined credible sets of SNPs that were 95% likely, based on posterior probability, to contain the causal disease-associated SNPs, and showed the value of more detailed mapping to target sequences for functional studies.
Abstract: To further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group and 3 diseases: type 2 diabetes (T2D), coronary artery disease (CAD) and Graves' disease. We defined, using Bayes theorem, credible sets of SNPs that were 95% likely, based on posterior probability, to contain the causal disease-associated SNPs. In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN2A-CDKN2B (T2D), much of the posterior probability rested on a single SNP, and, in 4 other regions (CDKN2A-CDKN2B (CAD) and CDKAL1, FTO and HHEX (T2D)), the 95% sets were small, thereby excluding most SNPs as potentially causal. Very few SNPs in our credible sets had annotated functions, illustrating the limitations in understanding the mechanisms underlying susceptibility to common diseases. Our results also show the value of more detailed mapping to target sequences for functional studies.
468 citations
TL;DR: Observed rates of superoxide generation by rat skeletal muscle mitochondria under a variety of conditions suggest that quinone-binding site inhibitors can make complex I adopt the highly radical-producing state that occurs during reverse electron transport.
468 citations
Authors
Showing all 16441 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Shizuo Akira | 261 | 1308 | 320561 |
| Trevor W. Robbins | 231 | 1137 | 164437 |
| Richard A. Flavell | 231 | 1328 | 205119 |
| George Davey Smith | 224 | 2540 | 248373 |
| Nicholas J. Wareham | 212 | 1657 | 204896 |
| Cyrus Cooper | 204 | 1869 | 206782 |
| Martin White | 196 | 2038 | 232387 |
| Frank E. Speizer | 193 | 636 | 135891 |
| Michael Rutter | 188 | 676 | 151592 |
| Richard Peto | 183 | 683 | 231434 |
| Terrie E. Moffitt | 182 | 594 | 150609 |
| Kay-Tee Khaw | 174 | 1389 | 138782 |
| Chris D. Frith | 173 | 524 | 130472 |
| Phillip A. Sharp | 172 | 614 | 117126 |
| Avshalom Caspi | 170 | 524 | 113583 |