Showing papers by "Medical University of South Carolina published in 1968"
TL;DR: Ten cases of an unusual form of carcinoma involving the submucosal glands and ducts of the nasal and oral cavities and the larynx were collected and reviewed and found to be extremely aggressive and highly malignant.
Abstract: Ten cases of an unusual form of carcinoma involving the submucosal glands and ducts of the nasal and oral cavities and the larynx were collected and reviewed. The histopathologic features were defined and four distinct component parts were classified: ductal carcinoma in situ, adenocarcinoma, squamous cell carcinoma, and a mixed carcinoma. This tumor was found to be extremely aggressive and highly malignant, with 80% of the cases showing histopathologically proven metastases. The histopathologic features and the clinical behavior of this tumor were sufficiently distinctive to warrant the designation adenosquamous carcinoma. The mode of therapy was evaluated and the treatment of choice appears to be radical surgery. However, the limited number of cases indicates that further collection and subsequent analyses of additional cases must be performed before any definitive conclusions can be drawn.
168 citations
TL;DR: Ultrastructural cytochemical observations revealed peroxidase reactivity in primary (azurophil) granules, but not in secondary (specific)granules, of rabbit and human polymorphonuclear leukocytes.
96 citations
TL;DR: Evidence indicates that alanosine may interfere with the conversion of inosine monophosphate to adenosine monphosphate, and inhibition of RNA adenine synthesis is not antagonized by glutamine or aspartate.
45 citations
26 citations
TL;DR: It was tentatively concluded that the drug depresses the activity of aspartate transcarbamylase and adenylosuccinate synthetase and that the inhibition by the drug of the growth of the organism was antagonized by aspartates.
26 citations
TL;DR: The heart was enlarged, with the point of maximal intensity in the sixth left inter costal space 2 cm.
Abstract: lungs were clear to percussion and ausculta tion. The heart was enlarged, with the point of maximal intensity in the sixth left inter costal space 2 cm. lateral to the midclavicular line. There was a grade IV/VI harsh sys tolic murmur at the apex which was trans mitted to the axilla. The tender edge of the liver was palpable 3 cm. below the right costal margin. The spleen was not palpable. Any movement of the trunk or lower ex tremities elicited pain in the sacral region. A trace of edema was present in the ankles. No embolic lesions were noted in the ex tremities and there was no clubbing of the fingers.
24 citations
TL;DR: Mechanisms are described whereby reduced rates of blood flow through capillaries and the plugging of capillary damage brain, liver, and heart.
22 citations
18 citations
TL;DR: Two major hypotheses or propositions are presented: 1.
Abstract: As is well known, the severely burned patient is highly susceptible to infection (Liedberg et al., 1954; Artz & Teschan, 1957; Altemeier & MacMillan, 1962; Tumbusch et al., 1962). Although his life may be saved during the immediate postburn circulatory shock phase, he may die later with an overwhelming infection. The exact cause or causes for this increased susceptibility of the postburn patient to the development of severe infections and bacteremias are certainly not well worked out. There comes a time in scientific investigations when one cap or must step back from individual experiments, look over a whole field of knowledge, try to see exactly where we are, and try to find out what experiments should be done next. Thus the purpose of this paper is to utilize several kinds of knowledge' in order to establish new working hypotheses (i.e., testable guesses) on the problems presented by the susceptibility of the postburn human being to infection. This paper presents two major hypotheses or propositions : 1. A part of the increased susceptibility to the development of severe infections probably is a direct result of the enforced postponement of the selective ingestion of bacteria by phagocytic cells. 2. The fluids now necessarily given to the postburn patients to save their lives during the postburn circulatory shock interlude may be postponing or preventing bacteria from entering phagocytic cells.
13 citations
TL;DR: The effect of the sequential contraceptive on alkaline and acid phosphatase activity in the endometrium was evaluated and there was essentially no difference in the control and study groups and acid phosphate activity was noted throughout the menstrual cycle.
12 citations
TL;DR: Il a été conclu que ces acides hydroxamiques, comme l'HU, interviennent, à un degré plus ou moins grand, avec réduction des ribosides.
Abstract: L'action inhibitrice de l'hydroxyuree (HU) sur une synthese de DNA peut etre antagonisee par des deoxyribosides (dR). De meme, un melange de deoxyadenosine, de deoxyguanosine, et de deoxycytidine annule completement l'action de l'acide oxanyl hydroxamique (OHA) et inverse, en partie, les effets de l'acide salicylhydroxamique (SHA) et de l'acide (dihydroxybenzoyl-2.3)-hydroxamique (DHB). Lorsqu'on ajoute de la thymidine a une solution de dR, le schema general d'antagonisme est similaire. De plus, en presence des quatre dR, l'action de l'acetoxyoxamide (AOA) est en partie antagonisee. Il a ete conclu que ces acides hydroxamiques, comme l'HU, interviennent, a un degre plus ou moins grand, avec reduction des ribosides.
TL;DR: Rabbit heterophil leukocytes at an early stage of development contain abundant granules rich in sulfated mucosaccharide, strongly basic protein, and acid phosphatase, which form part of a Golgi complex exhibiting unique morphologic features.
TL;DR: It appears that good retrograde flow from the right coronary artery through the collaterals and left coronary artery into the pulmonary artery is of extreme importance prior to consideration for surgical intervention.
TL;DR: Assay of inhibitory action against DNA synthesis in an ascites tumor cell system in vitro revealed an order of relative potentcy of MHU > HU > EHU, and cross resistance to HU and MHU was shown in a microbial system, but EH U was without effect on the bacteria at the concentrations used.
TL;DR: Alanosine is an inhibitor of glutamic acid carboxy-lyase (C-L) of bacterial origin, but not of those from squash and rat brain, while other bacterial amino acid C-L's tested, while sensitive to hydroxylamine, are not inhibited by alanosine.
Abstract: SummaryAlanosine is an inhibitor of glutamic acid carboxy-lyase (C-L) of bacterial origin, but not of those from squash and rat brain. Its action is competitive in respect to glutamic acid, but noncompetitive in respect to pyridoxal phosphate. Other bacterial amino acid C-L's tested, while sensitive to hydroxylamine, are not inhibited by alanosine.
01 Jan 1968
TL;DR: The tissue distribution of enzymatic activities in intestinal metaplasia stomachs exhibiting chronic gastritis was compared histochemically with that of the small intestine in man.
Abstract: The tissue distribution of enzymatic activities in intestinal metaplasia stomachs exhibiting chronic gastritis was compared histochemically with that of the small intestine in man.
TL;DR: With the doses used, propanidid had a more distinct effect on myocardial contractile force, blood pressure and right atrial pressure than methohexital and the differences were statistically significant.
Abstract: SUMMARY
The cardiovascular effect of the new ultrashort-acting nonbarbituric intravenous anaesthetic agent propanidid (Epontol®) was investigated and compared with anaesthetically equipotent doses of methohexital (Brietal®) in open-chest rabbits under pentobarbital anaesthesia. With the doses used, propanidid had a more distinct effect on myocardial contractile force, blood pressure and right atrial pressure than methohexital. The differences were statistically significant.
ZUSAMMENFASSUNG
Die kardiovaskularen Wirkungen des neuen ultrakurzwirkenden intravenosen Anaesthetikums Propanidid (Epontol) wurden untersucht und mit gleich stark wirkenden Dosen von Methohexital an Kaninchen mit offenem Thorax unter Pentobarbitalanaesthesie verglichen. In den angewandten Dosierungen hatte Propanidid einen deutlichen Effekt auf die Kontraktionskraft des Myocards, den Blutdruck und den rechten Vorhofsdruck gegenuber Methohexital. Die Unterschiede waren statistisch signifikant.
TL;DR: His enduring contribution to proctology—past, present and future—namely, the founding and development of an institution devoted to diseases of the rectum and colon—the St. Mark’s Hospital.
Abstract: On the occasion of the 100th anniversary of the death of Frederick Salmon, an English surgeon, little known in his lifetime, this presentation focuses attention on his books which, when originally written, promoted few manifestations of interest and concern, and calls attention to his enduring contribution to proctology—past, present and future—namely, the founding and development of an institution devoted to diseases of the rectum and colon—the St. Mark’s Hospital.
TL;DR: Une évaluation plus poussée de ces 3 agents ainsi que d'autres acides hydroxamiques dans une série of systèmes d'essai sur les virus paraît clairement indiquée.
Abstract: L'acide oxamyl-hydroxamique, l'acide salicylhydroxamique et l'acetoxyoxamide inhibent la reproduction du bacteriophage T4 dans l'Escherichia coli B. L'activite de chacun de ces composes etait plus grande que celle de l'hydroxyuree dans le meme systeme d'essai. De ce fait, une evaluation plus poussee de ces 3 agents ainsi que d'autres acides hydroxamiques dans une serie de systemes d'essai sur les virus parait clairement indiquee.
TL;DR: Fifteen listeners with sensorineural hearing loss and 15 normal listeners were administered the Fairbanks Rhyme Test and CID Auditory Test W-22 at −4, 0, 8, 16, 24, 32, and 40 dB sensation levels.
Abstract: Fifteen listeners with sensorineural hearing loss and 15 normal listeners were administered the Fairbanks Rhyme Test and CID Auditory Test W-22 at −4, 0, 8, 16, 24, 32, and 40 dB sensation levels. ...
TL;DR: Because protein for rebuilding tissue cannot be given intravenously, it must be fed orally, and patients require 20 gm of nitrogen per square meter of body surface after a serious burn.
Abstract: Because protein for rebuilding tissue cannot be given intravenously, it must be fed orally. After a serious burn, patients require 20 gm of nitrogen per square meter of body surface. Giving high-protein powder between meals or by tube feeding can help make up deficits.
TL;DR: Recovery of Clostridium perfringens in rhesus monkeys was considerably higher and proved to be an autochthonous organism for those animals receiving cholesterol as a dietary supplement and there was no indication, however, that C. perfringen would lower blood cholesterol levels of conventionalized animals as has been suggested by other reports dealing with monocontamination of germ free animals.
01 Dec 1968