Institution
Medical University Plovdiv
Education•Plovdiv, Bulgaria•
About: Medical University Plovdiv is a education organization based out in Plovdiv, Bulgaria. It is known for research contribution in the topics: Population & Health care. The organization has 1183 authors who have published 1924 publications receiving 18091 citations.
Topics: Population, Health care, Schizophrenia, Anxiety, Quality of life
Papers published on a yearly basis
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Ludwig Maximilian University of Munich1, Uppsala University2, Tel Aviv University3, Oregon State University4, Medical University Plovdiv5, Wageningen University and Research Centre6, Pompeu Fabra University7, University of British Columbia8, Technische Universität München9, University of Edinburgh10, University of Wollongong11
TL;DR: In this article, potential pathways linking greenspace to health are presented in three domains, which emphasize three general functions of greenspace: reducing harm (e.g., reducing exposure to air pollution, noise and heat), restoring capacities (i.e., attention restoration and physiological stress recovery), and encouraging physical activity and facilitating social cohesion). Interrelations between among the three domains are also noted.
1,187 citations
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TL;DR: Attractions between heterochromatic regions are essential for phase separation of the active and inactive genome in inverted and conventional nuclei, whereas chromatin–lamina interactions are necessary to build the conventional genomic architecture from these segregated phases.
Abstract: The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic and inactive heterochromatic regions of the genome1,2. In conventional nuclei, microscopy shows that euchromatin is localized in the nuclear interior and heterochromatin at the nuclear periphery1,2. Genome-wide chromosome conformation capture (Hi-C) analyses show this segregation as a plaid pattern of contact enrichment within euchromatin and heterochromatin compartments3, and depletion between them. Many mechanisms for the formation of compartments have been proposed, such as attraction of heterochromatin to the nuclear lamina2,4, preferential attraction of similar chromatin to each other1,4–12, higher levels of chromatin mobility in active chromatin13–15 and transcription-related clustering of euchromatin16,17. However, these hypotheses have remained inconclusive, owing to the difficulty of disentangling intra-chromatin and chromatin–lamina interactions in conventional nuclei18. The marked reorganization of interphase chromosomes in the inverted nuclei of rods in nocturnal mammals19,20 provides an opportunity to elucidate the mechanisms that underlie spatial compartmentalization. Here we combine Hi-C analysis of inverted rod nuclei with microscopy and polymer simulations. We find that attractions between heterochromatic regions are crucial for establishing both compartmentalization and the concentric shells of pericentromeric heterochromatin, facultative heterochromatin and euchromatin in the inverted nucleus. When interactions between heterochromatin and the lamina are added, the same model recreates the conventional nuclear organization. In addition, our models allow us to rule out mechanisms of compartmentalization that involve strong euchromatin interactions. Together, our experiments and modelling suggest that attractions between heterochromatic regions are essential for the phase separation of the active and inactive genome in inverted and conventional nuclei, whereas interactions of the chromatin with the lamina are necessary to build the conventional architecture from these segregated phases. Attractions between heterochromatic regions are essential for phase separation of the active and inactive genome in inverted and conventional nuclei, whereas chromatin–lamina interactions are necessary to build the conventional genomic architecture from these segregated phases.
397 citations
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TL;DR: It is suggested that probiotic treatment of diseases other than dental caries and periodontal disease should also be systematically investigated.
Abstract: Probiotics have been extensively studied for their health-promoting effects. The main field of research has been in the gastrointestinal tract. However, in the past few years probiotics have also been investigated in the oral health perspective, which is the topic of the present review. We discuss the mechanisms of bacterial adhesion, potential of probiotics in oral cavity colonization, interspecies interactions, and possible effects on immunomodulation, and means of probiotic administration. We suggest that probiotic treatment of diseases other than dental caries and periodontal disease should also be systematically investigated. In general, hardly any randomized controlled trials have been conducted in this area and the studies on probiotics vs oral health are still in their cradle. Hence, much more investigations are called for before any evidence-based conclusions can be drawn: if or not probiotic therapy can be recommended for oral health purposes.
320 citations
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Children's Hospital of Eastern Ontario1, French Institute of Health and Medical Research2, University of Washington3, King Abdulaziz City for Science and Technology4, University of Leicester5, University of Toronto6, University of Santiago de Compostela7, Leiden University Medical Center8, McGill University9, Qatar Airways10, National Institutes of Health11, Pompeu Fabra University12, Johns Hopkins University School of Medicine13, University of British Columbia14, Wellcome Trust Sanger Institute15, University of South Florida16, Charles University in Prague17, Katholieke Universiteit Leuven18, Broad Institute19, Charité20, University of Hong Kong21, Medical University Plovdiv22, Istituto Superiore di Sanità23, Radboud University Nijmegen24, Maastricht University25, Seattle Children's26, Newcastle University27
TL;DR: The current and future bottlenecks to gene discovery are reviewed and strategies for enabling progress are suggested for enabling precision medicine for this patient population.
Abstract: Provision of a molecularly confirmed diagnosis in a timely manner for children and adults with rare genetic diseases shortens their "diagnostic odyssey," improves disease management, and fosters genetic counseling with respect to recurrence risks while assuring reproductive choices. In a general clinical genetics setting, the current diagnostic rate is approximately 50%, but for those who do not receive a molecular diagnosis after the initial genetics evaluation, that rate is much lower. Diagnostic success for these more challenging affected individuals depends to a large extent on progress in the discovery of genes associated with, and mechanisms underlying, rare diseases. Thus, continued research is required for moving toward a more complete catalog of disease-related genes and variants. The International Rare Diseases Research Consortium (IRDiRC) was established in 2011 to bring together researchers and organizations invested in rare disease research to develop a means of achieving molecular diagnosis for all rare diseases. Here, we review the current and future bottlenecks to gene discovery and suggest strategies for enabling progress in this regard. Each successful discovery will define potential diagnostic, preventive, and therapeutic opportunities for the corresponding rare disease, enabling precision medicine for this patient population.
280 citations
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TL;DR: Once‐monthly subcutaneous administration of fitusiran resulted in dose‐dependent lowering of the antithrombin level and increased thrombin generation in participants with hemophilia A or B who did not have inhibitory alloantibodies.
Abstract: BackgroundCurrent hemophilia treatment involves frequent intravenous infusions of clotting factors, which is associated with variable hemostatic protection, a high treatment burden, and a risk of the development of inhibitory alloantibodies. Fitusiran, an investigational RNA interference (RNAi) therapy that targets antithrombin (encoded by SERPINC1), is in development to address these and other limitations. MethodsIn this phase 1 dose-escalation study, we enrolled 4 healthy volunteers and 25 participants with moderate or severe hemophilia A or B who did not have inhibitory alloantibodies. Healthy volunteers received a single subcutaneous injection of fitusiran (at a dose of 0.03 mg per kilogram of body weight) or placebo. The participants with hemophilia received three injections of fitusiran administered either once weekly (at a dose of 0.015, 0.045, or 0.075 mg per kilogram) or once monthly (at a dose of 0.225, 0.45, 0.9, or 1.8 mg per kilogram or a fixed dose of 80 mg). The study objectives were to ass...
279 citations
Authors
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Name | H-index | Papers | Citations |
---|---|---|---|
Michael Maes | 115 | 807 | 52050 |
Uwe Wollina | 48 | 1033 | 12459 |
Ioana Berindan-Neagoe | 45 | 302 | 7693 |
Fabio Pitta | 44 | 213 | 11925 |
Andrew Miles | 43 | 178 | 6640 |
Morten Schiødt | 40 | 121 | 7232 |
Denitsa Docheva | 34 | 103 | 4271 |
Boris Sakakushev | 32 | 65 | 3148 |
Savita Rangarajan | 28 | 88 | 4947 |
Buranee Kanchanatawan | 23 | 72 | 1384 |
Angel M. Dzhambov | 21 | 76 | 1945 |
Nikolai Zhelev | 19 | 79 | 1590 |
Donka D. Dimitrova | 18 | 60 | 1659 |
Nikolay Mehterov | 17 | 26 | 710 |
Georgi Iskrov | 16 | 44 | 617 |