scispace - formally typeset
Search or ask a question
Institution

Meerut Institute of Engineering and Technology

About: Meerut Institute of Engineering and Technology is a based out in . It is known for research contribution in the topics: Quantitative structure–activity relationship & Drug delivery. The organization has 369 authors who have published 426 publications receiving 3795 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: This review presents the up to date development on the design and development of different thiazole derivatives.
Abstract: In the last few decades, a lot of work has been done on thiazole ring to find new compounds related to this scaffold to act as antioxidant, analgesic, anti-inflammatory, antimicrobial, antifungal, antiviral, diuretic, anticonvulsant, neuroprotective, and antitumor or cytotoxic drug molecules with lesser side effects. This review presents the up to date development on the design and development of different thiazole derivatives.

188 citations

Journal ArticleDOI
TL;DR: This review focused on the various aspects useful in development of GRDF including the current trends and advancements.
Abstract: In the present era, gastroretentive dosage forms (GRDF) receive great attention because they can improve the performance of controlled release systems. An optimum GRDF system can be defined as a system which retains in the stomach for a sufficient time interval against all the physiological barriers, releases active moiety in a controlled manner, and finally is easily metabolized in the body. Physiological barriers like gastric motility and gastric retention time (GRT) act as obstacles in developing an efficient GRDF. Gastroretention can be achieved by developing different systems like high density systems, floating drug delivery systems (FDDS), mucoadhesive systems, expandable systems, superporous systems, and magnetic systems. All these systems have their own merits and demerits. This review focused on the various aspects useful in development of GRDF including the current trends and advancements.

144 citations

Journal ArticleDOI
TL;DR: The evidence supporting JNK as a potent therapeutic target, and small molecules from various chemical classes as JNK inhibitors are summarized.
Abstract: JNK pathway regulates various physiological processes including inflammatory responses, cell differentiation, cell proliferation, cell death, cell survival and expression of proteins. Deregulation of JNK is linked with various diseases including neurodegenerative disease, autoimmune disease, diabetes, cancer, cardiac hypertrophy and asthma. Three distinct genes JNK1, JNK2 and JNK3 have been identified as regulator of JNK pathway. JNK1 and JNK2 have broad tissue distribution and play a potential role in insulin resistance, inflammation and cell signaling. JNK3 is predominantly found in the CNS neurons, making it an attractive target for neurodegenerative disorders. In this review, we summarize the evidence supporting JNK as a potent therapeutic target, and small molecules from various chemical classes as JNK inhibitors.

138 citations

Journal ArticleDOI
TL;DR: This article focuses on synthetic development and pharmacological activity of the triazole moiety which exhibit a broad spectrum of Pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc.
Abstract: Several five membered ring systems, e.g., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at symmetrical or asymmetrical positions have been studied because of their interesting pharmacological properties. In this article our emphasis is on synthetic development and pharmacological activity of the triazole moiety which exhibit a broad spectrum of pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc. Triazoles have increased our ability to treat many fungal infections, for example, candidiasis, cryptococcal meningitis, aspergillosis etc. However, mortality due to these infections even with antifungal therapy is still unacceptably high. Therefore, the development of new antifungal agents targeting specific fungal structures or functions is being actively pursued. Rapid developments in molecular mycology have led to a concentrated search for more target antifungals. Although we are entering a new era of antifungal therapy in which we will continue to be challenged by systemic fungal diseases, the options for treatment will have greatly expanded.

135 citations

Book ChapterDOI
TL;DR: The present effort was undertaken to review lead stress effects on the physiobiochemical activity of higher plants, and found that lead inhibition of enzyme activities results from the interaction of the metal with enzyme -SH groups.
Abstract: Lead is a metallic pollutant emanating from various environmental sources including industrial wastes, combustion of fossil fuels, and use of agrochemicals. Lead may exist in the atmosphere as dusts, fumes, mists, and vapors, and in soil as a mineral. Soils along roadsides are rich in lead because vehicles burn leaded gasoline, which contributes to environmental lead pollution. Other important sources of lead pollution are geological weathering, industrial processing of ores and minerals, leaching of lead from solid wastes, and animal and human excreta. Lead is nondegradable, readily enters the food chain, and can subsequently endanger human and animal health. Lead is one of the most important environment pollutants and deserves the increasing attention it has received in recent decades. The present effort was undertaken to review lead stress effects on the physiobiochemical activity of higher plants. Lead has gained considerable attention as a potent heavy metal pollutant because of growing anthropogenic pressure on the environment. Lead-contaminated soils show a sharp decline in crop productivity. Lead is absorbed by plants mainly through the root system and in minor amounts through the leaves. Within the plants, lead accumulates primarily in roots, but some is translocated to aerial plant parts. Soil pH, soil particle size, cation-exchange capacity, as well as root surface area, root exudation, and mycorrhizal transpiration rate affect the availability and uptake of lead by plants. Only a limited amount of lead is translocated from roots to other organs because there are natural plant barriers in the root endodermis. At lethal concentrations, this barrier is broken and lead may enter vascular tissues. Lead in plants may form deposits of various sizes, present mainly in intercellular spaces, cell walls, and vacuoles. Small deposits of this metal are also seen in the endoplasmic reticulum, dictyosome, and dictyosome-derived vesicles. After entering the cells, lead inhibits activities of many enzymes, upsets mineral nutrition and water balance, changes the hormonal status, and affects membrane structure and permeability. Visual, nonspecific symptoms of lead toxicity are stunted growth, chlorosis, and blackening of the root system. In most cases, lead inhibition of enzyme activities results from the interaction of the metal with enzyme -SH groups. The activities of metalloenzymes may decline as a consequence of displacement of an essential metal by lead from the active sites of the enzymes. Lead decreases the photosynthetic rate of plants by distorting chloroplast ultrastructure, diminishing chlorophyll synthesis, obstructing electron transport, and inhibiting activities of Calvin cycle enzymes.

123 citations


Authors

Showing all 369 results

NameH-indexPapersCitations
Vinod Kumar7781526882
Pankaj Sharma5864312601
Rajendra Awasthi181071538
Vivek K. Pawar18401118
Rishabha Malviya171161296
Mansi Verma1645806
Vipin Kumar Garg1667897
Pankaj Tyagi16891074
Mohd Tariq15185851
V. K. Singh1536478
Shobhit Kumar1435422
Ram Chakka1360762
Kiran More1326751
Rupesh Dudhe13471093
Garima Garg1323743
Network Information
Related Institutions (5)
Birla Institute of Technology and Science
13.9K papers, 170K citations

86% related

Jamia Millia Islamia
9.8K papers, 166.8K citations

83% related

Savitribai Phule Pune University
10.6K papers, 216K citations

81% related

Panjab University, Chandigarh
18.7K papers, 461K citations

81% related

Aligarh Muslim University
16.4K papers, 289K citations

81% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20223
202167
202065
201955
201830
201710