Showing papers by "Memorial Sloan Kettering Cancer Center published in 1970"
TL;DR: The first two years after definitive surgery were shown to be the critical period for studying the course of the disease and age and location of the tumor were found to affect the time of onset of pulmonary metastasis but not the five-year survival figure.
Abstract: A consecutive series of 145 central-type osteogenic sarcomas in the long bones of patients under the age of twenty-one years was studied by analysis of the interval from surgery to onset of pulmonary metastasis and the interval from the onset of pulmonary metastasis to death. The effects of the time of surgery, age, sex, race, preoperative duration of symptoms, location of tumor, and preoperative radiation on the course of the disease were analyzed.
One hundred and twenty-one patients had pulmonary metastasis prior to the end of the study and died of their disease. Twenty-four patients were free of metastasis at the end of the study. The five-year survival rate was 17.4 per cent.
Age and location of the tumor were found to affect the time of onset of pulmonary metastasis but not the five-year survival figure. The first two years after definitive surgery were shown to be the critical period for studying the course of the disease.
The data analyzed in this study may offer a valuable control series against which future methods of treatment can be evaluated.
337 citations
TL;DR: An unusual instance of fibrous dysplasia of the maxilla in a 3-year-old boy caused grotesque deformity during a period of 13 years that was the cause of his death at 16 years of age.
Abstract: An unusual instance of fibrous dysplasia of the maxilla in a 3-year-old boy caused grotesque deformity during a period of 13 years It was the cause of his death at 16 years of age The lesion was originally diagnosed as osteogenic sarcoma Death occurred after an unsuccessful attempt at surgical resection
15 citations
11 citations
TL;DR: In assessing the probabilities of long-term survival of cancer patients, numerous factors merit consideration, some of them are peculiarly applicable for growths that arise primarily in the thyroid gland.
7 citations
TL;DR: This study was undertaken to evaluate the effect of hemorrhagic shock on the coagulation mechanism and to correlate these alterations with the metabolic effects of shock.
Abstract: * From the Division of Surgical Research, Sloan-Kettering Institute for Cancer Research, and Cornell Medical College, New York, N. Y. This work was supported by National Cancer Institute Grant CA-08748 and by Institutional Funds. † Senior Resident in Surgery, Memorial Sloan-Kettering Cancer Center, New York, N. Y. ‡ Attending Surgeon, Thoracic Surgical Service, Memorial Sloan-Kettering Cancer Center. Associate Professor Clinical Surgery, Cornell University Medical College, New York, N. Y. This study was undertaken to evaluate the effect of hemorrhagic shock on the coagulation mechanism and to correlate these alterations with the metabolic effects of shock. Heparin and fibrinolysin were used to determine their
4 citations
TL;DR: Growth of a transplanted Walker 256 carcinosarcoma in rats was accompanied by an increase in plasma fibrinogen and urinary trypsin inhibitors and a significant decrease in plasma plasminogen and hematocrit.
Abstract: Growth of a transplanted Walker 256 carcinosarcoma in rats was accompanied by: 1) An increase in plasma fibrinogen and urinary trypsin inhibitors; 2) A significant decrease in plasma plasminogen an...
2 citations
TL;DR: These symptom complexes and metabolic aberrations do not neces sarily signify dissemination or mop erability, except for those syndromes which are usually associated with a predominately undifferentiated and rapidly proliferating tumor.
Abstract: ed to distinguish the clinical and bio chemical features of malignant tumors that do not arise from the mechanical effects of metastatic or locally invasive disease, nor from the iatrogenic effects of therapeutic manipulation. In some instances, these multisystemic mani festations dominate the clinical pres entation of the cancer so that aware ness and recognition of their signifi cance and degree of specificity will facilitate earlier diagnosis and proper treatment. These symptom complexes and metabolic aberrations do not neces sarily signify dissemination or mop erability, except for those syndromes which are usually associated with a predominately undifferentiated and rapidly proliferating tumor. Apart from their clinical signifi cance, these syndromes have profound biologic implications. In regard to the endocrine syndromes, there is pre sumptive evidence that a tumor arising from nonendocrine tissue synthesizes peptides and proteins with hormonal activity. These paradoxical hormonal effects are believed to arise from the derepression or activation of latent coding functions in the DNA of tumor
2 citations