Memorial University of Newfoundland

About: Memorial University of Newfoundland is a education organization based out in St. John's, Newfoundland and Labrador, Canada. It is known for research contribution in the topics: Population & Gadus. The organization has 13818 authors who have published 27785 publications receiving 743594 citations. The organization is also known as: Memorial University & Memorial University of Newfoundland and Labrador.

Oxygen- and capacity-limited thermal tolerance: blurring ecology and physiology

Abstract: The Commentary by Portner, Bock and Mark ([Portner et al., 2017][1]) elaborates on the oxygen- and capacity-limited thermal tolerance (OCLTT) hypothesis. Journal of Experimental Biology Commentaries allow for personal and controversial views, yet the journal also mandates that ‘opinion and fact

Common variants in P2RY11 are associated with narcolepsy

Abstract: Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune disease. We here report genome-wide association analyses for narcolepsy with replication and fine mapping across three ethnic groups (3,406 individuals of European ancestry, 2,414 Asians and 302 African Americans). We identify a SNP in the 3' untranslated region of P2RY11, the purinergic receptor subtype P2Y₁₁ gene, which is associated with narcolepsy (rs2305795, combined P = 6.1 × 10⁻¹⁰, odds ratio = 1.28, 95% CI 1.19-1.39, n = 5689). The disease-associated allele is correlated with reduced expression of P2RY11 in CD8(+) T lymphocytes (339% reduced, P = 0.003) and natural killer (NK) cells (P = 0.031), but not in other peripheral blood mononuclear cell types. The low expression variant is also associated with reduced P2RY11-mediated resistance to ATP-induced cell death in T lymphocytes (P = 0.0007) and natural killer cells (P = 0.001). These results identify P2RY11 as an important regulator of immune-cell survival, with possible implications in narcolepsy and other autoimmune diseases.

A longitudinal study of the effect of an interprofessional education curriculum on student satisfaction and attitudes towards interprofessional teamwork and education

Abstract: There has been limited research on the effect of interprofessional education (IPE) over time on the attitudes of undergraduate health and human service professional students. Previous research in this area has suggested that students from different professions report differing attitudes towards IPE and interprofessional teamwork, and such attitudes may also be influenced by other background characteristics of the students themselves (e.g., gender, age). The purpose of this study was to evaluate the longitudinal effect of the introduction of an IPE curriculum on students' attitudes towards IPE and teamwork. A time series study design was conducted to assess the attitudes of undergraduate health and human service professional students towards IPE and teamwork, and students were also asked to complete satisfaction surveys after IPE curriculum activities. Significant differences in the attitudes of students from different professions and their satisfaction with participation in IPE were reported over the duration of the study. Overall, student satisfaction with IPE participation was relatively positive; however the introduction of IPE curriculum during their undergraduate education did not appear to have a significant longitudinal effect on attitudes towards IPE or interprofessional teamwork. The findings have implications for the design and integration of IPE curriculum within existing uni-professional curriculum.

Laminar Forced Convection Heat Transfer in the Combined Entry Region of Non-Circular Ducts

Abstract: A new model for predicting Nusselt numbers in the combined entrance region of non-circular ducts and channels is developed. This model predicts both local and average Nusselt numbers and is valid for both isothermal and isoflux boundary conditions. The model is developed using the asymptotic results for convection from a flat plate, thermally developing flows in non-circular ducts, and fully developed flow in non-circular ducts. Through the use of a novel characteristic length scale, the square root of cross-sectional area, the effect of duct shape on Nusselt number is minimized. Comparisons are made with several existing models for the circular tube and parallel plate channel and with numerical data for several non-circular ducts

Trace Element Partitioning in Immiscible Silicate–Carbonate Liquid Systems: an Initial Experimental Study Using a Centrifuge Autoclave

Abstract: The origin of carbonatites remains a contentious topic. However, INTRODUCTION an important role for liquid immiscibility between silicate and Silicate–carbonate liquid immiscibility has often been carbonate liquids has often been proposed. To understand and proposed as a possible mechanism for the origin of constrain the role this process may play, it is important to have carbonatites associated with ultramafic alkaline rocks in trace element partitioning data available. Few experimental studies composite volcanic and subvolcanic complexes. Field on trace element partitioning between silicate and carbonate liquids observations (Ferguson & Currie, 1971; Kjarsgaard & have been undertaken, reflecting both analytical and experimental Peterson, 1991; Church & Jones, 1995) and data on difficulties. To achieve better phase separation new two-liquid melt inclusions in minerals (Rankin & Le Bas, 1974; experiments have been performed utilizing the rotating centrifuge Romanchev & Sokolov, 1979) support the role of liquid autoclave. Trace elements in the run products were analysed in situ immiscibility in carbonatite petrogenesis. Since the piusing laser ablation microprobe–inductively coupled plasma mass oneering work of Koster van Groos & Wyllie (1963) spectrometry. Partition coefficients (D) have been determined for the separation of carbonatitic immiscible liquids from selected rare earth elements (La, Nd, Sm, Tb, Er, Tm), high field carbonated silicate melts has been demonstrated exstrength elements (Zr, Hf, Nb, Ta), and for Sr, Ba and Y. Most perimentally in many synthetic silicate–carbonate systems of the rare earth elements partition preferentially into the silicate and for natural rock compositions [e.g. see review by liquid. La, Sr and Ba, however, strongly partition into the carbonate Kjarsgaard & Hamilton (1989)]. However, there is no liquid. The high field strength elements, although all preferentially consensus about the role of liquid immiscibility in the partitioning into the silicate liquid, are characterized by a wide development of carbonatite magmas (see Gittins, 1989). range of D values. Zr and Hf have similar D values, which are In this connection, quantitative experimental data on one to two orders of magnitude lower than those of Nb, Ta and trace element partitioning between the immiscible liquids Ti. Ti and Nb behave similarly, whereas Ta demonstrates behaviour are important for constraining the origin of carbonatites. intermediate to that of Zr and Hf. Nb/Ta ratios are strongly Experimental studies in silicate–carbonate systems are fractionated by two-liquid partitioning. hampered by the rapid crystallization of carbonate-rich