Institution
Memorial University of Newfoundland
Education•St. John's, Newfoundland and Labrador, Canada•
About: Memorial University of Newfoundland is a education organization based out in St. John's, Newfoundland and Labrador, Canada. It is known for research contribution in the topics: Population & Context (language use). The organization has 13818 authors who have published 27785 publications receiving 743594 citations. The organization is also known as: Memorial University & Memorial University of Newfoundland and Labrador.
Topics: Population, Context (language use), Health care, Gadus, Computer science
Papers published on a yearly basis
Papers
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TL;DR: The results support in‐utero transfer of high‐risk pregnancies to a tertiary level facility because outborn infants were less mature and more ill than inborn infants at NICU admission.
196 citations
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TL;DR: The functional consequences that phagocytosis plays in both the healthy and diseased CNS are reviewed, and how it contributes to overall pathophysiological mechanisms involved in brain injury and repair is summarized.
Abstract: Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during development, homeostasis, and diseased states. Phagocytosis is a highly complex process that is specialized for the uptake and removal of opsonized and non-opsonized targets, such as pathogens, apoptotic cells, and cellular debris. While the role of phagocytosis in mediating classical innate and adaptive immune responses has been known for decades, it is now appreciated that phagocytosis is also critical throughout early neural development, homeostasis, and initiating repair mechanisms. As such, modulating phagocytic processes has provided unexplored avenues with the intent of developing novel therapeutics that promote repair and regeneration in the CNS. Here, we review the functional consequences that phagocytosis plays in both the healthy and diseased CNS, and summarize how phagocytosis contributes to overall pathophysiological mechanisms involved in brain injury and repair.
195 citations
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Erasmus University Rotterdam1, University of Sassari2, University of Lübeck3, University of Western Australia4, University of Pennsylvania5, Radboud University Nijmegen Medical Centre6, University of Exeter7, University of Helsinki8, University of Edinburgh9, University of Maryland, Baltimore10, National Institutes of Health11, Leiden University12, University of Washington13, Sir Charles Gairdner Hospital14, University College Cork15, Università telematica San Raffaele16, Radboud University Nijmegen17, University of Glasgow18, University of Milan19, University of Cagliari20, Group Health Cooperative21, McGill University22, Memorial Sloan Kettering Cancer Center23, Wellcome Trust Sanger Institute24, University of Groningen25, Memorial University of Newfoundland26, Harvard University27, Veterans Health Administration28, Cedars-Sinai Medical Center29, King's College London30
TL;DR: A large meta-analysis of genome-wide association studies for serum levels of the highly heritable thyroid function markers TSH and FT4 improves the current knowledge of the regulation of hypothalamic-pituitary-thyroid axis function and the consequences of genetic variation for hypo- or hyperthyroidism.
Abstract: Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associated with weight changes, atrial fibrillation, osteoporosis, and psychiatric disorders. To identify novel variants underlying thyroid function, we performed a large meta-analysis of genome-wide association studies for serum levels of the highly heritable thyroid function markers TSH and FT4, in up to 26,420 and 17,520 euthyroid subjects, respectively. Here we report 26 independent associations, including several novel loci for TSH (PDE10A, VEGFA, IGFBP5, NFIA, SOX9, PRDM11, FGF7, INSR, ABO, MIR1179, NRG1, MBIP, ITPK1, SASH1, GLIS3) and FT4 (LHX3, FOXE1, AADAT, NETO1/FBXO15, LPCAT2/CAPNS2). Notably, only limited overlap was detected between TSH and FT4 associated signals, in spite of the feedback regulation of their circulating levels by the hypothalamic-pituitary-thyroid axis. Five of the reported loci (PDE8B, PDE10A, MAF/LOC440389, NETO1/FBXO15, and LPCAT2/CAPNS2) show strong gender-specific differences, which offer clues for the known sexual dimorphism in thyroid function and related pathologies. Importantly, the TSH-associated loci contribute not only to variation within the normal range, but also to TSH values outside the reference range, suggesting that they may be involved in thyroid dysfunction. Overall, our findings explain, respectively, 5.64% and 2.30% of total TSH and FT4 trait variance, and they improve the current knowledge of the regulation of hypothalamic-pituitary-thyroid axis function and the consequences of genetic variation for hypo- or hyperthyroidism.
195 citations
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TL;DR: Effect of single and dual hydrothermal modifications with annealing (ANN) and heat-moisture treatment (HMT) on molecular structure and physicochemical properties of corn starch was investigated and ANN and HMT as well as dual modifications increased RDS content and decreased SDS and RS content.
195 citations
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TL;DR: The use of the roller-massager had no significant effect on muscle strength, and can provide statistically significant increases in ROM, particularly when used for a longer duration.
Abstract: Background:
Foam rollers are used to mimic myofascial release techniques and have been used by therapists, athletes, and the general public alike to increase range of motion (ROM) and alleviate pressure points. The roller‐massager was designed to serve a similar purpose but is a more portable device that uses the upper body rather than body mass to provide the rolling force.
195 citations
Authors
Showing all 13990 results
Name | H-index | Papers | Citations |
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Daniel Levy | 212 | 933 | 194778 |
Rakesh K. Jain | 200 | 1467 | 177727 |
Peter W.F. Wilson | 181 | 680 | 139852 |
Martin G. Larson | 171 | 620 | 117708 |
Peter B. Jones | 145 | 1857 | 94641 |
Dafna D. Gladman | 129 | 1036 | 75273 |
Guoyao Wu | 122 | 764 | 56270 |
Fereidoon Shahidi | 119 | 951 | 57796 |
David Harvey | 115 | 738 | 94678 |
Robert C. Haddon | 112 | 577 | 52712 |
Se-Kwon Kim | 102 | 763 | 39344 |
John E. Dowling | 94 | 305 | 28116 |
Mark J. Sarnak | 94 | 393 | 42485 |
William T. Greenough | 93 | 200 | 29230 |
Soottawat Benjakul | 92 | 891 | 34336 |