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Institution

Memorial University of Newfoundland

EducationSt. John's, Newfoundland and Labrador, Canada
About: Memorial University of Newfoundland is a education organization based out in St. John's, Newfoundland and Labrador, Canada. It is known for research contribution in the topics: Population & Gadus. The organization has 13818 authors who have published 27785 publications receiving 743594 citations. The organization is also known as: Memorial University & Memorial University of Newfoundland and Labrador.


Papers
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Journal ArticleDOI
TL;DR: A significant role for the liver is indicated in the regulation of plasma homocysteine levels in rats fed a high protein diet enriched with serine, and in vivo effects of serine were examined.
Abstract: Recent evidence suggests that an increased plasma concentration of the sulphur amino acid homocysteine is a risk factor for the development of vascular disease. The tissue(s) responsible for homocysteine production and export to the plasma are not well known. However, given the central role of the liver in amino acid metabolism, we developed a rat primary hepatocyte model in which homocysteine (and cysteine) production and export were examined. The dependence of homocysteine export from incubated hepatocytes on methionine concentration fitted well to a rectangular hyperbola, with half-maximal homocysteine export achieved at methionine concentrations of approx. 0.44 mM. Hepatocytes incubated with 1 mM methionine and 1 mM serine (a substrate for the transulphuration pathway of homocysteine removal) produced and exported significantly less homocysteine (25-40%) compared with cells incubated with 1 mM methionine alone. The effects of dietary protein on homocysteine metabolism were also examined. Rats fed a 60% protein diet had a significantly increased total plasma homocysteine level compared with rats fed a 20% protein diet. In vitro effects of dietary protein were examined using hepatocytes isolated from animals maintained on these diets. When incubated with 1 mM methionine, hepatocytes from rats fed the high protein diet exported significantly more homocysteine compared with hepatocytes from rats fed the normal protein diet. Inclusion of serine significantly lowered homocysteine export in the normal protein group, but the effect was more marked in the high protein group. In vivo effects of serine were also examined. Rats fed a high protein diet enriched with serine had significantly lower total plasma homocysteine (25-30%) compared with controls. These data indicate a significant role for the liver in the regulation of plasma homocysteine levels.

193 citations

Journal ArticleDOI
TL;DR: In this article, an observational study investigated the effects of gender of teacher, gender of student, and classroom subject (mathematics vs. English literature/language) on teacher-student interactions.
Abstract: An observational study investigated the effects of gender of teacher, gender of student, and classroom subject (mathematics vs. English literature/language) on teacher–student interactions. A total of 597 high school students (294 males and 303 females) and 36 teachers (28 males and 8 females) were observed in either 18 mathematics classes or 18 literature/language classes. Students and teachers were predominately Caucasian, with the majority of students from a lower- or middle-class background. Observations were coded using the interactions for sex equity in classroom teaching (INTERSECT) observational instrument. It was found that female mathematics teachers, male literature/language teachers, and female literature/language teachers tended to interact somewhat more with male students than with female students. This tendency was not the result of male students having initiated more direct verbal interactions with teachers.

192 citations

Journal ArticleDOI
TL;DR: In this article, a responsible tourism lens is used to measure the impact of cruise tourism on coastal and marine environments, local economies, and on the sociocultural nature of port communities.

192 citations

Journal ArticleDOI
TL;DR: The findings suggest that the accumulation of specific genetic alterations in MSI-positive colorectal cancers is markedly heterogeneous, because the occurrence of some mutations, but not others (eg, transforming growth factor beta type II receptor gene), depends on the underlying basis of the mismatch repair deficiency.
Abstract: A subset of hereditary and sporadic colorectal carcinomas is defined by microsatellite instability (MSI), but the spectra of gene mutations have not been characterized extensively. Thirty-nine hereditary nonpolyposis colorectal cancer syndrome carcinomas (HNPCCa) and 57 sporadic right-sided colonic carcinomas (SRSCCa) were evaluated. Of HNPCCa, 95% (37/39) were MSI-positive as contrasted with 31% (18/57) of SRSCCa ( P P = 0.08). Absence of nuclear hMSH2 mismatch repair gene product by immunohistochemistry was associated with germline hMSH2 mutation ( P = 0.0007). The prevalence of K- ras proto-oncogene mutations was similar in HNPCCa and SRSCCa (30% (11/37) and 30% (16/54)), but no HNPCCa from patients with germline hMSH2 mutation had codon 13 mutation ( P = 0.02), and two other HNPCCa had multiple K- ras mutations attributable to subclones. 18q allelic deletion and p53 gene product overexpression were inversely related to MSI ( P = 0.0004 and P = 0.0001, respectively). Frameshift mutation of the transforming growth factor β type II receptor gene was frequent in all MSI-positive cancers (85%, 46/54), but mutation of the E2F-4 transcription factor gene was more common in HNPCCa of patients with germline hMSH2 mutation than in those with germline hMLH1 mutation (100% (8/8) versus 40% (2/5), P = 0.04), and mutation of the Bax proapoptotic gene was more frequent in HNPCCa than in MSI-positive SRSCCa (55% (17/31) versus 13% (2/15), P = 0.01). The most common combination of mutations occurred in only 23% (8/35) of evaluable MSI-positive cancers. Our findings suggest that the accumulation of specific genetic alterations in MSI-positive colorectal cancers is markedly heterogeneous, because the occurrence of some mutations (eg, ras , E2F-4 , and Bax genes), but not others (eg, transforming growth factor β type II receptor gene), depends on the underlying basis of the mismatch repair deficiency. This genetic heterogeneity may contribute to the heterogeneous clinical and pathological features of MSI-positive cancers.

192 citations

Journal ArticleDOI
TL;DR: There is some evidence of a gradual increase in disorder as the drying layer become thinner, but no sudden transition, in contrast to what has been seen in previous experiments.
Abstract: We have studied shrinkage-crack patterns which form when a thin layer of an alumina/water slurry dries. Both isotropic and directional drying were studied. The dynamics of the pattern formation process and the geometric properties of the isotropic crack patterns are similar to what is expected from recent models, assuming weak disorder. There is some evidence of a gradual increase in disorder as the drying layer become thinner, but no sudden transition, in contrast to what has been seen in previous experiments. The morphology of the crack patterns is influenced by drying gradients and front propagation effects, with sharp gradients having a strong orienting and ordering effect.

192 citations


Authors

Showing all 13990 results

NameH-indexPapersCitations
Daniel Levy212933194778
Rakesh K. Jain2001467177727
Peter W.F. Wilson181680139852
Martin G. Larson171620117708
Peter B. Jones145185794641
Dafna D. Gladman129103675273
Guoyao Wu12276456270
Fereidoon Shahidi11995157796
David Harvey11573894678
Robert C. Haddon11257752712
Se-Kwon Kim10276339344
John E. Dowling9430528116
Mark J. Sarnak9439342485
William T. Greenough9320029230
Soottawat Benjakul9289134336
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202386
2022269
20211,808
20201,749
20191,568
20181,516