Memorial University of Newfoundland

About: Memorial University of Newfoundland is a education organization based out in St. John's, Newfoundland and Labrador, Canada. It is known for research contribution in the topics: Population & Gadus. The organization has 13818 authors who have published 27785 publications receiving 743594 citations. The organization is also known as: Memorial University & Memorial University of Newfoundland and Labrador.

A Temporal Ratio Model of Memory

Abstract: A model of memory retrieval is described. The model embodies 4 main claims: (a) temporal memory-traces of items are represented in memory partly in terms of their temporal distance from the present; (b) scale-similarity-similar mechanisms govern retrieval from memory over many different timescales; (c) local distinctiveness-performance, on a range of memory tasks is determined by interference from near psychological neighbors; and (d) interference-based forgetting-all memory loss is due to interference and not trace decay. The model is applied to data on free recall and serial recall. The account emphasizes qualitative similarity in the retrieval principles involved in memory performance at all timescales, contrary to models that emphasize distinctions between short-term and long-term memory.

Relativistic electron pitch-angle scattering by electromagnetic ion cyclotron waves during geomagnetic storms

Abstract: During magnetic storms, relativistic electrons execute nearly circular orbits about the Earth and traverse a spatially confined zone within the duskside plasmapause where electromagnetic ion cyclotron (EMIC) waves are preferentially excited. We examine the mechanism of electron pitch-angle diffusion by gyroresonant interaction with EMIC waves as a cause of relativistic electron precipitation loss from the outer radiation belt. Detailed calculations are carried out of electron cyclotron resonant pitch-angle diffusion coefficients Dααfor EMIC waves in a multi-ion (H+, He+, O+) plasma. A simple functional form for Dαα is used, based on quasi-linear theory that is valid for parallel-propagating, small-amplitude electromagnetic waves of general spectral density. For typical observed EMIC wave amplitudes (l-10nT), the rates of resonant pitch-angle diffusion are close to the limit of "strong" diffusion, leading to intense electron precipitation. In order for gyroresonance to take place, electrons must possess a minimum kinetic energy Emin which depends on the value of the ratio (electron plasma frequency/ electron gyrofrequency); Emin also depends on the properties of the EMIC wave spectrum and the ion composition. Geophysically interesting scattering, with Emin comparable to 1 MeV, can only occur in regions where (electron plasma frequency/electron gyrofrequency) ≥ 10, which typically occurs within the duskside plasmapause. Under such conditions, electrons with energy ≥ 1 MeV can be removed from the outer radiation belt by EMIC wave scattering during a magnetic storm over a time-scale of several hours to a day.

Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

Abstract: Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To elucidate the role of age-related epigenetic changes in healthy ageing and potential longevity, we tested for association between whole-blood DNA methylation patterns in 172 female twins aged 32 to 80 with age and age-related phenotypes. Twin-based DNA methylation levels at 26,690 CpG-sites showed evidence for mean genome-wide heritability of 18%, which was supported by the identification of 1,537 CpG-sites with methylation QTLs in cis at FDR 5%. We performed genome-wide analyses to discover differentially methylated regions (DMRs) for sixteen age-related phenotypes (ap-DMRs) and chronological age (a-DMRs). Epigenome-wide association scans (EWAS) identified age-related phenotype DMRs (ap-DMRs) associated with LDL (STAT5A), lung function (WT1), and maternal longevity (ARL4A, TBX20). In contrast, EWAS for chronological age identified hundreds of predominantly hyper-methylated age DMRs (490 a-DMRs at FDR 5%), of which only one (TBX20) was also associated with an age-related phenotype. Therefore, the majority of age-related changes in DNA methylation are not associated with phenotypic measures of healthy ageing in later life. We replicated a large proportion of a-DMRs in a sample of 44 younger adult MZ twins aged 20 to 61, suggesting that a-DMRs may initiate at an earlier age. We next explored potential genetic and environmental mechanisms underlying a-DMRs and ap-DMRs. Genome-wide overlap across cis-meQTLs, genotype-phenotype associations, and EWAS ap-DMRs identified CpG-sites that had cis-meQTLs with evidence for genotype-phenotype association, where the CpG-site was also an ap-DMR for the same phenotype. Monozygotic twin methylation difference analyses identified one potential environmentally-mediated ap-DMR associated with total cholesterol and LDL (CSMD1). Our results suggest that in a small set of genes DNA methylation may be a candidate mechanism of mediating not only environmental, but also genetic effects on age-related phenotypes.