Memorial University of Newfoundland

About: Memorial University of Newfoundland is a education organization based out in St. John's, Newfoundland and Labrador, Canada. It is known for research contribution in the topics: Population & Gadus. The organization has 13818 authors who have published 27785 publications receiving 743594 citations. The organization is also known as: Memorial University & Memorial University of Newfoundland and Labrador.

Inhibitory Activities of Soluble and Bound Millet Seed Phenolics on Free Radicals and Reactive Oxygen Species

Abstract: Oxidative stress, caused by reactive oxygen species (ROS), is responsible for modulating several pathological conditions and aging. Soluble and bound phenolic extracts of commonly consumed millets,...

The Canadian STOP-PAIN project – Part 1: Who are the patients on the waitlists of multidisciplinary pain treatment facilities?

Abstract: The Canadian STOP-PAIN Project assessed the human and economic burden of chronic pain in individuals on waitlists of Multidisciplinary Pain Treatment Facilities (MPTF) This article presents the patients’ bio-psycho-social profile A sample of 728 patients was recruited from waitlists of eight university-affiliated MPTFs across Canada Subjects completed validated questionnaires to: 1) assess the characteristics and impact of their pain; and 2) evaluate their emotional functioning and quality of life (QoL) Follow-up questionnaires were completed by a subgroup of 271 patients three months later Close to 2/3 of the participants reported severe pain (≥ 7/10) that interfered substantially with various aspects of their daily living and QoL Severe or extremely severe levels of depression were common (500%) along with suicidal ideation (346%) Patients aged > 60 yr were twice as likely to experience severe pain (≥ 7/10) as their younger counterparts (P = 0002) Patients with frequent sleep problems were more at risk of reporting severe pain (P ≤ 0003) Intense pain was also associated with a greater tendency to catastrophize (P < 00001) severe depressive symptoms (P = 0003) and higher anger levels (P = 0016) Small but statistically significant changes in pain intensity and emotional distress were observed over a three-month wait time (all P < 005) This study highlights the severe impairment that patients experience waiting for treatment in MPTFs Knowing that current facilities cannot meet the clinical demand, it is clear that effective prevention/treatment strategies are needed earlier in primary and secondary care settings to minimize suffering and chronicity

New U–Pb ages for Early Ordovician magmatism in Central Spain

Abstract: Felsic orthogneisses occur widely in the Ollo de Sapo Domain of the Central Iberian Zone, most of which were previously considered to represent a Precambrian basement to the Palaeozoic sequences of this domain. However, new U–Pb dating across the Berzosa‐Riaza shear zone (Sierra de Guadarrama, Central Spain) indicates an Early Ordovician age for the most representative types of orthogneisses in the eastern part of the Ollo de Sapo Domain. Dated rocks include the volcaniclastic Cardoso gneiss (480±2 Ma); from the low–medium‐grade hanging wall; the Riaza gneiss (468 −8 +16 Ma, mylonitic granite) in the Berzosa‐Riaza shear zone; three types of ‘leucogneiss’ (Buitrago gneiss; 488 −8 +10 Ma, megacrystic granite; 482 −11 +14 Ma, aplitic vein; and 482 −8 +9 Ma, gneissic leucogranite); and the La Morcuera granitic augen gneiss (477±4 Ma) in the high‐grade footwall. The new age of the Cardoso gneiss brackets to the Mid–Late Arenig, the so‐called Early Ordovician Sardic unconformity, characteristic of the Central Iberian Zone. These new ages suggest that the broadly coeval volcanism and plutonism were closely associated with the Sardic events, and that these orthogneisses were part of a felsic magmatic belt which extended along the Ollo de Sapo Domain of the Central Iberian Zone. This magmatic belt is interpreted to have been active during the Early Ordovician break‐up of the peri‐Gondwanan margin of the Iapetus Ocean.

Comparison of commercial enzyme immunoassay kits with plaque reduction neutralization test for detection of measles virus antibody.

Abstract: Four commercially available enzyme immunoassay (EIA) kits were evaluated in comparison with the plaque reduction neutralization (PRN) test for detection of measles virus antibody. The EIA kits, Enzygnost (Behring), Diamedix, Vidas (bioMerieux Vitek), and Measlestat (Biowhittaker), were assessed with two PRN cutoff titers: a PRN titer of 8, the lowest detectable antibody level by the PRN test under the test conditions, and a titer of 120, which has been shown to be the minimum protective antibody titer. At a PRN cutoff titer of 8, the sensitivity was 88.2, 91.1, 74.6, and 69.8% for Behring, Diamedix, Vidas, and Biowhittaker EIA tests, respectively, with negative predictive values ranging from 22.7 to 45.5%. The specificity was 93.8% for Diamedix and 100% for the rest. At a PRN cutoff titer of 120, the sensitivity and specificity, respectively, were 100 and 90.7% (Behring), 98.2 and 58.8% (Diamedix), 90.6 and 94.5% (Vidas), and 85.7 and 96.4% (Biowhittaker). At this PRN cutoff titer, the negative predictive values of all EIA tests improved considerably, ranging from 70.7 to 100%. The EIA results showed an excellent association with PRN results when the PRN titers of the test samples were either 1,052. Discrepancies occurred especially when testing samples having PRN titers in the range of 8 to 120, indicating lack of sensitivity of the EIA tests in detecting measles virus antibody at low levels. Maternally derived measles virus antibody at this level has been shown to interfere with measles vaccine response in children and hence has implications from the standpoint of measles immunization. The ready availability, ease of operation, and rapid turnaround time are strong plus points of the EIA kits, and they could be useful in a clinical laboratory setting for routine application, but they may have limited use in vaccine-related studies and seroepidemiological surveys.