Memorial University of Newfoundland

About: Memorial University of Newfoundland is a education organization based out in St. John's, Newfoundland and Labrador, Canada. It is known for research contribution in the topics: Population & Context (language use). The organization has 13818 authors who have published 27785 publications receiving 743594 citations. The organization is also known as: Memorial University & Memorial University of Newfoundland and Labrador.

Content of insoluble bound phenolics in millets and their contribution to antioxidant capacity.

Abstract: Soluble and insoluble-bound phenolic extracts of several varieties of millet (kodo, finger, foxtail, proso, pearl, and little millets) whole grains were evaluated for their phenolic contents and antioxidative efficacy using trolox equivalent antioxidant capacity (TEAC), reducing power (RP), and beta-carotene-linoleate model system as well as ferrous chelating activity. In addition, ferulic and p-coumaric acids were present in soluble and bound phenolic fractions of millets, and their contents were determined using high-performance liquid chromatography (HPLC) and HPLC-mass spectrometry (MS). Kodo millet had the highest total phenolic content, whereas proso millet possessed the least. All millet varieties showed high antioxidant activities, although the order of their efficacy was assay dependent. HPLC analysis of millet phenolic extracts demonstrated that the bound fractions contained more ferulic and p-coumaric acids compared to their soluble counterparts. The results of this study showed that soluble as well as bound fractions of millet grains are rich sources of phenolic compounds with antioxidant, metal chelating, and reducing power. The potential of whole millets as natural sources of antioxidants depends on the variety used. The importance of the insoluble bound fraction of millet as a source of ferulic acid and p-coumaric acid was established, and their contribution to the total phenolic content must be taken into account in the assessment of the antioxidant activity of millets.

Effect of certolizumab pegol on signs and symptoms in patients with psoriatic arthritis: 24-week results of a Phase 3 double-blind randomised placebo-controlled study (RAPID-PsA).

Abstract: Objectives To evaluate the efficacy and safety of certolizumab pegol (CZP) after 24 weeks in RAPID-PsA (NCT01087788), an ongoing Phase 3 trial in patients with psoriatic arthritis (PsA). Methods Patients were randomised 1:1:1 to placebo, 200 mg CZP every 2 weeks (Q2W) or 400 mg CZP every 4 weeks (Q4W). Patients could have had exposure to one previous tumour necrosis factor (TNF) inhibitor therapy. Primary endpoints were American College of Rheumatology 20% (ACR20) response at week 12 and modified Total Sharp Score change from baseline at week 24. Secondary endpoints included; Psoriatic Arthritis Response Criteria (PsARC) score, Health Assessment Questionnaire Disability Index (HAQ-DI), Psoriasis Area and Severity Index, Leeds Enthesitis Index, Leeds Dactylitis Index, and Modified Nail Psoriasis Severity Index. Results Of 409 patients randomised, 368 completed 24 weeks of treatment. ACR20 response was significantly greater in CZP 200 mg Q2W and 400 mg Q4W-treated patients than placebo (58.0% and 51.9% vs 24.3% (p<0.001)) at week 12, with improvements observed by week 1. There was a statistically significant improvement in physical function from baseline, measured by HAQ-DI in CZP patients compared with placebo (−0.50 vs −0.19, p<0.001) and more patients treated with CZP 200 mg Q2W and CZP 400 mg achieved an improvement in PsARC at week 24 than placebo (78.3% and 77.0% vs 33.1% (p<0.001)). Sustained improvements were observed in psoriatic skin involvement, enthesitis, dactylitis and nail disease. Higher ACR20 response with CZP was independent of prior TNF inhibitor exposure. No new safety signals were observed. Conclusions Rapid improvements in the signs and symptoms of PsA, including joints, skin, enthesitis, dactylitis and nail disease were observed across both CZP dosing regimens.

Diet studies of seabirds: a review and recommendations

Abstract: We review the different methods that are used to collect dietary data from marine birds. We consider their limitations and practicalities and emphasize critical data gaps in our knowledge of the feeding ecology of seabirds (na mely diets outside breeding seasons). To enhance comparability of findings among studies, species, and oceanographic regions, we make recommendations on standards for the reporting of results in the literature.

Multisite, multifrequency tensor decomposition of magnetotelluric data

Abstract: Accurate interpretation of magnetotelluric data requires an understanding of the directionality and dimensionality inherent in the data, and valid implementation of an appropriate method for removing the effects of shallow, small-scale galvanic scatterers on the data to yield responses representative of regionalscale structures. The galvanic distortion analysis approach advocated by Groom and Bailey has become the most adopted method, rightly so given that the approach decomposes the magnetotelluric impedance tensor into determinable and indeterminable parts, and tests statistically the validity of the galvanic distortion assumption. As proposed by Groom and Bailey, one must determine the appropriate frequency-independent telluric distortion parameters and geoelectric strike by fitting the seven-parameter model on a frequencyby-frequency and site-by-site basis independently. Although this approach has the attraction that one gains a more intimate understanding of the data set, it is rather time-consuming and requires repetitive application. We propose an extension to Groom-Bailey decomposition in which a global minimum is sought to determine the most appropriate strike direction and telluric distortion parameters for a range of frequencies and a set of sites. Also, we show how an analytically-derived approximate Hessian of the objective function can reduce the required computing time. We illustrate application of the analysis to two synthetic data sets and to real data. Finally, we show how the analysis can be extended to cover the case of frequency-dependent distortion caused by the magnetic effects of the galvanic charges.