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Institution

Memorial University of Newfoundland

EducationSt. John's, Newfoundland and Labrador, Canada
About: Memorial University of Newfoundland is a education organization based out in St. John's, Newfoundland and Labrador, Canada. It is known for research contribution in the topics: Population & Gadus. The organization has 13818 authors who have published 27785 publications receiving 743594 citations. The organization is also known as: Memorial University & Memorial University of Newfoundland and Labrador.


Papers
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Journal ArticleDOI
TL;DR: In this article, the authors genotyped 7,264 MHC SNPs in 22,647 ankylosing spondylitis (AS) cases and controls of European descent.
Abstract: Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype.

219 citations

Journal ArticleDOI
TL;DR: The quality of the evidence supports a strong recommendation for the use of CBT-I among cancer survivors, and large effect sizes were observed for self-reported insomnia severity for those patients who received CBTs, representing a clinically relevant eight point reduction.

219 citations

Journal ArticleDOI
TL;DR: In this paper, a multivariate analysis of stable isotope and lipid data is proposed to quantify carbon cycling and transfer of materials in marine ecosystems using principal components analysis (PCA).
Abstract: Lipids provide the densest form of energy in marine ecosystems. They are also a solvent and absorption carrier for organic contaminants and thus can be drivers of pollutant bioaccumulation. Among the lipids, certain essential fatty acids and sterols are considered to be important determinants of ecosystem health and stability. Fatty acids and sterols are also susceptible to oxidative damage leading to cytotoxicity and a decrease in membrane fluidity. The physical characteristics of biological membranes can be defended from the influence of changing temperature, pressure, or lipid peroxidation by altering the fatty acid and sterol composition of the lipid bilayer. Marine lipids are also a valuable tool to measure inputs, cycling, and loss of materials. Their heterogeneous nature makes them versatile biomarkers that are widely used in marine trophic studies, often with the help of multivariate statistics, to delineate carbon cycling and transfer of materials. Principal components analysis has a strong following as it permits data reduction and an objective interpretation of results, but several more sophisticated multivariate analyses which are more quantitative are emerging too. Integrating stable isotope and lipid data can facilitate the interpretation of both data sets and can provide a quantitative estimate of transfer across trophic levels.

219 citations

Journal ArticleDOI
TL;DR: The results demonstrate that citrulline, produced by NO synthetase, can be recycled to arginine in macrophages, and may contribute to the regulation of intracellular availability of argininine and thus the prolonged production of NO by macrophage.
Abstract: Rat peritoneal macrophages were incubated in the presence of 0.05-1.0 mM-[14C]citrulline. The synthesis of [14C]arginine from 0.1 mM-[14C]citrulline was about 300 pmol/h per 10(6) cells in macrophages from saline-injected (control) rats. Both arginine synthesis from citrulline and nitrate production (an indicator of NO generation) were increased about 3-fold in the cells from lipopolysaccharide (LPS)-treated animals. The arginine synthesis was very sensitive to extracellular citrulline concentration in the range found in plasma (0.05-0.1 mM). The rate of arginine synthesis from citrulline was inhibited by about 20% by 0.5 mM-L-glutamine in both control and LPS-treated rat cells, but was inhibited by 0.5 mM-L-arginine only in control cells. Our results demonstrate that citrulline, produced by NO synthetase, can be recycled to arginine in macrophages. The citrulline-arginine cycle may contribute to the regulation of intracellular availability of arginine and thus the prolonged production of NO by macrophages.

219 citations

Journal ArticleDOI
TL;DR: In this article, the authors investigate the effectiveness of advertising alliances (in which two brands from different product categories are featured together in an advertisement) for introducing new product categories, and show that they can improve the performance of advertising.
Abstract: In this article, the authors investigate the effectiveness of advertising alliances (in which two brands from different product categories are featured together in an advertisement) for introducing...

218 citations


Authors

Showing all 13990 results

NameH-indexPapersCitations
Daniel Levy212933194778
Rakesh K. Jain2001467177727
Peter W.F. Wilson181680139852
Martin G. Larson171620117708
Peter B. Jones145185794641
Dafna D. Gladman129103675273
Guoyao Wu12276456270
Fereidoon Shahidi11995157796
David Harvey11573894678
Robert C. Haddon11257752712
Se-Kwon Kim10276339344
John E. Dowling9430528116
Mark J. Sarnak9439342485
William T. Greenough9320029230
Soottawat Benjakul9289134336
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202386
2022269
20211,808
20201,749
20191,568
20181,516