Institution
Michigan Molecular Institute
Company•Midland, Michigan, United States•
About: Michigan Molecular Institute is a company organization based out in Midland, Michigan, United States. It is known for research contribution in the topics: Polymer & Dendrimer. The organization has 223 authors who have published 362 publications receiving 13977 citations.
Topics: Polymer, Dendrimer, Monomer, Polymerization, Glass transition
Papers published on a yearly basis
Papers
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TL;DR: Starburst dendrimers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol.
Abstract: Starburst dendrimers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol. Protecting group strategies are crucial in these syntheses, which proceed via discrete “Aufbau” stages referred to as generations. Critical molecular design parameters (CMDPs) such as size, shape, and surface chemistry may be controlled by the reactions and synthetic building blocks used. Starburst dendrimers can mimic certain properties of micelles and liposomes and even those of biomolecules and the still more complicated, but highly organized, building blocks of biological systems. Numerous applications of these compounds are conceivable, particularly in mimicking the functions of large biomolecules as drug carriers and immunogens. This new branch of “supramolecular chemistry” should spark new developments in both organic and macromolecular chemistry.
3,022 citations
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TL;DR: In this paper, the rate of growth of chain-folded lamellar crystals from the subcooled melt of polyethylene fractions is treated in terms of surface nucleation theory with the objective of illuminating the origin of the chain folding phenomenon and associated kinetic effects in molecular terms.
955 citations
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644 citations
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TL;DR: The results indicate that Starburst dendrimers can be effective carriers for the introduction of regulatory nucleic acids and facilitate the suppression of the specific gene expression.
Abstract: Starburst polyamidoamine (PAMAM) dendrimers are a new type of synthetic polymer characterized by a branched spherical shape and a high density surface charge. We have investigated the ability of these dendrimers to function as an effective delivery system for antisense oligonucleotides and 'antisense expression plasmids' for the targeted modulation of gene expression. Dendrimers bind to various forms of nucleic acids on the basis of electrostatic interactions, and the ability of DNA-dendrimer complexes to transfer oligonucleotides and plasmid DNA to mediate antisense inhibition was assessed in an in vitro cell culture system. Cell lines that permanently express luciferase gene were developed using dendrimer mediated transfection. Transfections of antisense oligonucleotides or antisense cDNA plasmids into these cell lines using dendrimers resulted in a specific and dose dependent inhibition of luciferase expression. This inhibition caused approximately 25-50% reduction of baseline luciferase activity. Binding of the phosphodiester oligonucleotides to dendrimers also extended their intracellular survival. While dendrimers were not cytotoxic at the concentrations effective for DNA transfer, some non-specific suppression of luciferase expression was observed. Our results indicate that Starburst dendrimers can be effective carriers for the introduction of regulatory nucleic acids and facilitate the suppression of the specific gene expression.
453 citations
Authors
Showing all 223 results
Name | H-index | Papers | Citations |
---|---|---|---|
Nicholas J. Turro | 104 | 1131 | 53827 |
Donald A. Tomalia | 81 | 266 | 32422 |
Steffen Jockusch | 57 | 271 | 11350 |
Marcos Dantus | 52 | 369 | 9767 |
Lajos P. Balogh | 36 | 114 | 6575 |
M. Francesca Ottaviani | 36 | 117 | 4304 |
Martin F. Wojciechowski | 35 | 74 | 8349 |
Jing Li | 30 | 131 | 3544 |
Petar R. Dvornic | 29 | 104 | 2784 |
Sylvie Boileau | 27 | 162 | 2806 |
Patrick B. Smith | 24 | 79 | 5814 |
Leonid I. Klushin | 21 | 80 | 1493 |
Marc L. Mansfield | 21 | 34 | 2020 |
Raymond F. Boyer | 20 | 50 | 1153 |
Robert E. Hefner | 19 | 111 | 1221 |