Michigan State University

About: Michigan State University is a education organization based out in East Lansing, Michigan, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 60109 authors who have published 137074 publications receiving 5633022 citations. The organization is also known as: MSU & Michigan State.

A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate

Abstract: Introduction Accumulating evidence suggests that an imbalance between pro-angiogenic (i.e., vascular endothelial growth factor (VEGF) and placental growth factor (PlGF)) and anti-angiogenic factors (i.e., soluble VEGF receptor-1 (sVEGFR-1, also referred to as sFlt1)) is involved in the pathophysiology of preeclampsia (PE). Endoglin is a protein that regulates the pro-angiogenic effects of transforming growth factor beta, and its soluble form has recently been implicated in the pathophysiology of PE. The objective of this study was to determine if changes in maternal plasma concentration of these angiogenic and anti-angiogenic factors differ prior to development of disease among patients with normal pregnancies and those destined to develop PE (preterm and term) or to deliver a small for gestational age (SGA) neonate. Methods This longitudinal nested case-control study included 144 singleton pregnancies in the following groups: (1) patients with uncomplicated pregnancies who delivered appropriate for gestational age (AGA) neonates (n = 46); (2) patients who delivered an SGA neonate but did not develop PE (n = 56); and (3) patients who developed PE (n = 42). Longitudinal samples were collected at each prenatal visit, scheduled at 4-week intervals from the first or early second trimester until delivery. Plasma concentrations of soluble endoglin (s-Eng), sVEGFR-1, and PlGF were determined by specific and sensitive ELISA. Results (1) Patients destined to deliver an SGA neonate had higher plasma concentrations of s-Eng throughout gestation than those with normal pregnancies; (2) patients destined to develop preterm PE and term PE had significantly higher concentrations of s-Eng than those with normal pregnancies at 23 and 30 weeks, respectively (for preterm PE: p Conclusions (1) Changes in the maternal plasma concentration of s-Eng, sVEGFR-1, and PlGF precede the clinical presentation of PE, but only changes in s-Eng and PlGF precede the delivery of an SGA neonate; and (2) differences in the profile of angiogenic and anti-angiogenic response to intrauterine insults may determine whether a patient will deliver an SGA neonate, develop PE, or both.

Transnational Networks and Policy Diffusion: The Case of Gender Mainstreaming

Abstract: How can we account for the global diffusion of remarkably similar policy innovations across widely differing nation-states? In an era characterized by heightened globalization and increasingly radical state restructuring, this question has become especially acute. Scholars of international relations offer a number of theoretical explanations for the cross-national convergence of ideas, institutions, and interests. We examine the proliferation of state bureaucracies for gender mainstreaming. These organizations seek to integrate a gender-equality perspective across all areas of government policy. Although they so far have received scant attention outside of feminist policy circles, these mainstreaming bureaucracies—now in place in over 100 countries—represent a powerful challenge to business-as-usual politics and policymaking. As a policy innovation, the speed with which these institutional mechanisms have been adopted by the majority of national governments is unprecedented. We argue that transnational networks composed largely of nonstate actors (notably women's international nongovernmental organizations and the United Nations) have been the primary forces driving the diffusion of gender mainstreaming. In an event history analysis of 157 nation-states from 1975 to 1998, we assess how various national and transnational factors have affected the timing and the type of the institutional changes these states have made. Our findings support the claim that the diffusion of gender-mainstreaming mechanisms has been facilitated by the role played by transnational networks, in particular by the transnational feminist movement. Further, they suggest a major shift in the nature and the locus of global politics and national policymaking.

Composing adaptive software

Abstract: Interest in adaptive computing systems has increased dramatically in the past few years, and a variety of techniques now allow software to adapt dynamically to its environment. Compositional adaptation enables software to modify its structure and behavior dynamically in response to change in its execution environment. A review of current technology compares how, when, and where recomposition occurs.