Michigan State University

About: Michigan State University is a education organization based out in East Lansing, Michigan, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 60109 authors who have published 137074 publications receiving 5633022 citations. The organization is also known as: MSU & Michigan State.

GAL4-VP16 is an unusually potent transcriptional activator

Abstract: Recent work has defined a class of transcriptional activators1–5, members of which activate transcription in yeast, plant, insect and mammalian cells6–9. These proteins contain two parts: one directs DNA binding and the other, called the activating region, presumably interacts with some component of the transcriptional machinery. Activating regions are typically acidic and require some poorly-understood aspect of structure, probably at least in part an α-helix1–5,10. Here we describe a new member of this class, formed by fusing a DNA-binding fragment of the yeast activator GAL4 to a highly acidic portion of the herpes simplex virus protein VP16 (ref. 11; also called Vmw65). VP16 activates transcription of immediate early viral genes by using its amino-terminal sequences to attach to one or more host-encoded proteins that recognise DNA sequences in their promoters11–15. We show that the hybrid protein (GAL4-VP16) activates transcription unusually efficiently in mammalian cells when bound close to, or at large distances from the gene. We suggest that the activating region of VP16 may be near-maximally potent and that it is not coincidental that such a strong activator is encoded by a virus.

A survey of wormhole routing techniques in direct networks

Abstract: Several research contributions and commercial ventures related to wormhole routing, a switching technique used in direct networks, are discussed. The properties of direct networks are reviewed, and the operation and characteristics of wormhole routing are discussed in detail. By its nature, wormhole routing is particularly susceptible to deadlock situations, in which two or more packets may block one another indefinitely. Several approaches to deadlock-free. routing, along with a technique that allows multiple virtual channels to share the same physical channel, are described. In addition, several open issues related to wormhole routing are discussed. >

Global QCD analysis of parton structure of the nucleon: CTEQ5 parton distributions

Abstract: An up-to-date global QCD analysis of high energy lepton-hadron and hadron-hadron interactions is performed to better determine the gluon and quark parton distributions in the nucleon. Improved experimental data on inclusive jet production, in conjunction with precise deep inelastic scattering data, place good constraints on the gluon over a wide range of x; while new data on asymmetries in Drell-Yan processes contribute to better determine the d/u ratio. Comparisons with results of other recent global analyses are made, and the differences are described. Open issues and the general problem of determining the uncertainties of parton distributions are discussed.

The Relationship Between Productivity and Species Richness

Abstract: ▪ Abstract Recent overviews have suggested that the relationship between species richness and productivity (rate of conversion of resources to biomass per unit area per unit time) is unimodal (hump-shaped). Most agree that productivity affects species richness at large scales, but unanimity is less regarding underlying mechanisms. Recent studies have examined the possibility that variation in species richness within communities may influence productivity, leading to an exploration of the relative effect of alterations in species number per se as contrasted to the addition of productive species. Reviews of the literature concerning deserts, boreal forests, tropical forests, lakes, and wetlands lead to the conclusion that extant data are insufficient to conclusively resolve the relationship between diversity and productivity, or that patterns are variable with mechanisms equally varied and complex. A more comprehensive survey of the ecological literature uncovered approximately 200 relationships, of which 3...

Classroom Organization and Management.

Abstract: tunately, many of the theory-based ideas were incorrect or impractical for classroom use, and the experience-based advice was unsystematic and often contradictory. As a result, teachers were often left with the impression that classroom management is purely an art rather than partly an applied science and that "teachers have to find out what works best for them." Classroom research conducted in the