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Institution

Michigan Technological University

EducationHoughton, Michigan, United States
About: Michigan Technological University is a education organization based out in Houghton, Michigan, United States. It is known for research contribution in the topics: Population & Volcano. The organization has 8023 authors who have published 17422 publications receiving 481780 citations. The organization is also known as: MTU & Michigan Tech.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the behavior of the hydroxylated layer is modeled as a perfectly plastic, material, and a mechanistic model for material removal rate (MRR) in CMP is developed.
Abstract: It is well known that the chemical reaction between an oxide layer and a water-based slurry produces a softer hydroxylated interface layer. During chemical-mechanical polishing (CMP), it is assumed that material removal occurs by the plastic deformation of this interface layer. In this paper, the behavior of the hydroxylated layer is modeled as a perfectly plastic, material, and a mechanistic model for material removal rate (MRR) in CMP is developed. The deformation profile of the soft pad is approximated as the bending of a thin elastic beam. In addition to the dependence of MRR on pressure and relative velocity, the proposed plasticity-based model is also capable of delineating the effects of pad and slurry properties. The plasticity-based model is utilized to explore the effects of various design parameters (e.g., abrasive shape, size and concentration, and pad stiffness) on the MRR. Model predictions are compared with existing experimental observations from glass polishing, lapping, and CMP.

135 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the performance and emission characteristics of homogeneous charge compression ignition (HCCI) engines fueled with oxygenated fuels (i.e., butanol and ethanol).

135 citations

Journal ArticleDOI
03 Feb 2017-ACS Nano
TL;DR: An enzyme-free signal amplification technique is demonstrated, based on gold vesicles encapsulated with Pd-Ir nanoparticles as peroxidase mimics, for colorimetric assay of disease biomarkers with significantly enhanced sensitivity and overcomes the intrinsic limitations of enzymes.
Abstract: Enzyme-based colorimetric assays have been widely used in research laboratories and clinical diagnosis for decades. Nevertheless, as constrained by the performance of enzymes, their detection sensitivity has not been substantially improved in recent years, which inhibits many critical applications such as early detection of cancers. In this work, we demonstrate an enzyme-free signal amplification technique, based on gold vesicles encapsulated with Pd–Ir nanoparticles as peroxidase mimics, for colorimetric assay of disease biomarkers with significantly enhanced sensitivity. This technique overcomes the intrinsic limitations of enzymes, thanks to the superior catalytic efficiency of peroxidase mimics and the efficient loading and release of these mimics. Using human prostate surface antigen as a model biomarker, we demonstrated that the enzyme-free assay could reach a limit of detection at the femtogram/mL level, which is over 103-fold lower than that of conventional enzyme-based assay when the same antibod...

135 citations

Journal ArticleDOI
TL;DR: In this article, the results of experiments focused on characterizing the aerosol emissions associated with wet and dry turning were presented, and the relative importance of vaporization/condensation and atomization as mist generating mechanisms was also explored.

135 citations

Journal ArticleDOI
TL;DR: A method is proposed that makes it possible to infer the number of subpopulations by a mixture model, using a set of independent genetic markers and then testing the association between a genetic marker and a trait.
Abstract: Association mapping for complex diseases using unrelated individuals can be more powerful than family-based analysis in many settings. In addition, this approach has major practical advantages, including greater efficiency in sample recruitment. Association mapping may lead to false-positive findings, however, if population stratification is not properly considered. In this paper, we propose a method that makes it possible to infer the number of subpopulations by a mixture model, using a set of independent genetic markers and then testing the association between a genetic marker and a trait. The proposed method can be effectively applied in the analysis of both qualitative and quantitative traits. Extensive simulations demonstrate that the method is valid in the presence of a population structure.

134 citations


Authors

Showing all 8104 results

NameH-indexPapersCitations
Anil K. Jain1831016192151
Marc W. Kirschner162457102145
Yonggang Huang13679769290
Hong Wang110163351811
Fei Wang107182453587
Emanuele Bonamente10521940826
Haoshen Zhou10451937609
Nicholas J. Turro104113153827
Yang Shao-Horn10245849463
Richard P. Novick9929534542
Markus J. Buehler9560933054
Martin L. Yarmush9170234591
Alan Robock9034627022
Patrick M. Schlievert9044432037
Lonnie O. Ingram8831622217
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202349
2022154
2021882
2020891
2019892
2018893