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TL;DR: Reactivator K048 seems to be promising reactivator of tabun-inhibited AChE, whose reactivation potency is significantly higher than the efficacy of HI-6 and pralidoxime, and comparable with the potency of the obidoxime at human relevant doses.
Abstract: Four new AChE oximes for reactivation of acetylcholinesterase inhibited with tabun - K027 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide], K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide], K033 [1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide] and K048 [1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide] were prepared. Their efficacies to reactivate tabun-inhibited acetylcholinesterase were studied and compared with the currently used acetylcholinesterase reactivators (pralidoxime, obidoxime and HI-6). Reactivator K048 seems to be promising reactivator of tabun-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of HI-6 and pralidoxime, and comparable with the potency of the obidoxime at human relevant doses.
13 citations
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TL;DR: Endoscopic polypectomy alone dramatically reduced bowel frequency and colonic blood-loss in seven patients who had multiple schistosomal polyps which had persisted despite previous medical treatment.
13 citations
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TL;DR: In this paper, a system consisting of two identical units is considered, one operating as a cold standby unit and the other as a repairable unit, and the reliability characteristics of these two units are evaluated.
13 citations
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TL;DR: In this article, the spectral dyadic Green's function and volume integral-equation formulation were used to solve the resonance problem of rectangular dielectric resonators, and the effects of electrical and geometrical parameters on the resonance of the TE/sub 111/ mode of isolated DRs were also discussed.
Abstract: In this paper, the resonance problem of rectangular dielectric resonators (DRs) is analyzed by using the spectral dyadic Green's function and volume integral-equation formulation. The rectangular dielectric body is replaced by a set of entire-domain polarized volume current basis, and Galerkin's moment method is used to solve the resonant frequency and quality factor of the rectangular DR. The effects of electrical and geometrical parameters on the resonance of the TE/sub 111/ mode of isolated DRs are also presented. Additionally, the case of a rectangular DR with a ground plane is also discussed. Results are found to be in good agreement with the published experimental data.
13 citations
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TL;DR: In this article, a method of determining nonlinear form of dissipative characteristic is presented, where the deformation of a viscoelastic element which is made of tested material can be measured as displacement x of a single mass m in relative to a point of a complex vibratory system.
Abstract: The dissipative properties of most structural materials are usually described by a viscous damping parameter determining the rate of energy dissipation. The parameter stem from the traditionally adopted rheological Kelvin model. However, the analytical description of the dynamic properties of modern structural materials, including biological materials, often poses difficulties, due to the fact that the stress–strain dependence in these materials is not linear. Therefore a method of determining of nonlinear form of dissipative characteristic $$ D\left( {x,\dot{x}} \right) $$
(is presented. As it is assumed, mathematical function of the characteristic consist of nonlinear term g(x) of arbitrary form and so called mixed term κ(x)v where κ(x) is a function of deformation x and v—velocity of deformation. The deformation of a viscoelastic element which is made of tested material can be measured as displacement x of a single mass m in relative to a point of a complex vibratory system. The proper analysis of the mass m movement allows to evaluate the form of the functions g(x) and κ(x) what is a fundamental aim of the presented method. Beside of analytical method description some computer examples are presented. The method can be useful in evaluation of modern structural material properties (e.g. composites).
13 citations
Authors
Showing all 2478 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kamil Kuca | 55 | 1029 | 16708 |
Antoni Rogalski | 47 | 286 | 11516 |
Ufuk Gündüz | 44 | 206 | 6560 |
George P. Patrinos | 43 | 353 | 8785 |
Ching-Hsue Cheng | 42 | 209 | 8222 |
Saad M. Alshehri | 42 | 280 | 6179 |
Roman Dabrowski | 38 | 469 | 6415 |
Daniel Jun | 37 | 287 | 5505 |
Susheel Kalia | 36 | 105 | 6984 |
Dragan Pamučar | 36 | 194 | 4519 |
Turgay Celik | 35 | 508 | 5417 |
Janice D. Yoder | 33 | 81 | 3486 |
Miodrag Čolić | 32 | 212 | 3894 |
T. C. T. Ting | 32 | 121 | 9662 |
Manuela Tvaronavičienė | 31 | 153 | 2832 |