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TL;DR: Several new compounds showed a modest two-fold selectivity for the membrane-bound (bovine) isozyme, CA IV (bCA IV) as compared to the cytosolic human isozymes hCA I and II, in contrast to classical inhibitors which are 17–33 times less effective against bCA IV.
52 citations
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TL;DR: GC–MS analysis of HCPRE showed 10 different active compounds that have antimicrobial effects against pathogenic bacteria and fungi, especially alcoholic compounds, triazine derivatives and esters, including H. sabdariffa CPRE, which is the most potent, as it inhibited all testedacteria and fungi.
Abstract: Crude, phenolic-rich extracts (CPREs) were isolated from different sources, such as Hibiscus sabdariffa (H. sabdariffa), Brassica oleracea var. capitata f. rubra (B. oleracea) and Beta vulgaris (B. vulgaris) and characterized. These CPREs showed potential antibacterial and antifungal activities. H. sabdariffa CPRE (HCPRE) is the most potent, as it inhibited all tested bacteria and fungi. Total anthocyanins content (TAC), total phenolic content (TPC) and total flavonoid content (TFC) were estimated in all three CPREs. H. sabdariffa contained 4.2 mg/100 g TAC, 2000 mg/100 g of TPC and 430 mg/100 g of TFC in a dry weight sample. GC–MS analysis of HCPRE showed 10 different active compounds that have antimicrobial effects against pathogenic bacteria and fungi, especially alcoholic compounds, triazine derivatives and esters. Scanning and transmission electron microscopy images of Staphylococcus aureus DSM 1104 and Klebsiella pneumonia ATCC 43816 treated with HCPRE (50 μg/mL) exhibited signs of asymmetric, wrinkled exterior surfaces, cell deformations and loss of cell shapes; and adherence of lysed cell content led to cell clumping, malformations, blisters, cell depressions and diminished cell numbers. This indicates death of bacterial cells and loss of cell contents. Aspergillus ochraceus EMCC516 (A. ochraceus, when treated with 100 μg/mL of HCPRE showed irregular cell organelles and cell vacuolation.
51 citations
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TL;DR: In this paper, the nonlinear dynamic response and free vibration of FGP truncated conical panels with piezoelectric actuators in thermal environments are investigated by an analytical method.
Abstract: In this article, the nonlinear dynamic response and free vibration of functionally graded porous (FGP) truncated conical panel with piezoelectric actuators in thermal environments are investigated by an analytical method. The panel resting on an elastic foundation which is modeled according to the Winkler–Pasternak theory. The material properties including Young's modulus, shear modulus, and density are assumed to smoothly through the shell thickness. Three types of porosity distribution across the thickness, namely, symmetric porosity distribution, non-symmetric porosity, and uniform porosity distribution, are considered. Theoretical formulations are presented based on the first-order shear deformation shell theory with a von Karman-Donnell type of kinematic nonlinearity. The non-linear motion equations and resulting equations are derived by using Hamilton's principle, Galerkin's method, and Runge-Kutta method. Lastly, some numerical results are presented to study the effects of shell characteristics, porosity distribution, porosity coefficient, applied actuator voltage, temperature increment and elastic foundations on the nonlinear dynamic response and the natural frequencies of the piezoelectric FGP truncated conical panel.
51 citations
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TL;DR: How D numbers can be used when making a selection of an HCW management device is shown, and also how all the characteristics of such a device can be perceived and how the device demonstrating the best characteristics can be selected.
Abstract: Healthcare waste (HCW) management is a complex and challenging problem. It is one of the priorities in health. An increase in the number of the health services provided leads to an increase in the amount of HCW, which has particularly been noticeable in recent years. Since this is the waste that may pose a risk to humans and the environment, it is necessary to ensure an adequate treatment of the same. HCW management is particularly important in developing countries, due to inappropriate disposal methods, underfunding and a lack of the infrastructure. In order to achieve the cost-effectiveness and sustainability of this area, HCW should be minimized through an adequate treatment of the same. The Public Enterprise Zdravstvo Brcko (Brcko Health System) has intensively been addressing the HCW management issue. They have decided to upgrade the HCW system by purchasing a new infectious waste treatment facility. The paper is aimed at creating a new original integrated multicriteria decision-making model based on D numbers for processing fuzzy linguistic information. This model will serve to support management in the procurement of the mentioned facility. The model integrates the benefits of different approaches and theories. An initial model was formed, consisting of the six potential solutions evaluated based on the 18 criteria classified into the following four groups: social, environmental, economic and technological. Four experts in this field evaluated the criteria and potential solutions. Then, a new Best-Worst Method based on D numbers (BWM-D) was applied in order to determine the significance of the criteria. After that, a Multi-Attributive Border Approximation Area Comparison Based on D numbers (MABAC-D) was developed and applied so as to evaluate and select an infectious waste treatment facility. The results have shown that the alternative A1 gives the best results, whereas the alternative A5 shows the worst results. Finally, a sensitivity analysis was performed to validate the obtained results. In this part of the paper, the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS-D) and VIsekriterijumska Optimizacija Kompromisnog Resenja (VIKOR-D) were developed in order to validate the results. When procuring a new Contagious Waste Treatment System, the characteristics of the available devices need be perceived and all the criteria need be taken into account in order to provide a device which will solve the HCW problem in the best way. This paper has shown how D numbers can be used when making a selection of an HCW management device, and also how all the characteristics of such a device can be perceived and how the device demonstrating the best characteristics can be selected.
51 citations
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TL;DR: The spectrum of cutaneous B‐cell lymphomas in children significantly differs from the one in adults, and Diagnostic work‐up and treatment of paediatric patients with lymphomas are best achieved in close collaboration with paediatric haematopathologists and oncologists.
Abstract: Primary cutaneous lymphomas (CL) in children is rare. Only a few studies focused specifically on paediatric CL and therefore little is known whether primary CL in children are similar to or different from their adult counterparts with respect to the clinicopathological presentation, behaviour and prognosis. An extensive literature search using PubMed/MEDLINE from January 1995 through July 2014 was undertaken for articles reporting cases of paediatric CL. In addition, we identified 31 children with CL in our institutions. Mycosis fungoides and lymphomatoid papulosis are the two most prevalent lymphoma forms in children. A few entities of cutaneous lymphomas such as cutaneous diffuse large B-cell lymphoma leg type, and Sezary syndrome have not been reported so far in children. Other lymphoma entities such as hydroa vacciniforme-like lymphoma are mostly seen in certain geographic areas (Asia, Central and South America). In the paediatric population, low-malignant indolent forms such as primary cutaneous marginal zone lymphoma and primary cutaneous follicle centre lymphoma are very rare, whereas the more aggressive forms of B-cell lymphomas, precursor lymphoblastic lymphomas, and blastic plasmacytoid dendritic cell neoplasm are the most common forms in children, mostly involving the skin secondarily. Most paediatric lymphomas have similar clinicopathological features and course as their adults counterparts, particularly in the group of cutaneous T-cell lymphomas. The spectrum of cutaneous B-cell lymphomas in children significantly differs from the one in adults. Diagnostic work-up and treatment of paediatric patients with lymphomas are best achieved in close collaboration with paediatric haematopathologists and oncologists.
51 citations
Authors
Showing all 2478 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kamil Kuca | 55 | 1029 | 16708 |
Antoni Rogalski | 47 | 286 | 11516 |
Ufuk Gündüz | 44 | 206 | 6560 |
George P. Patrinos | 43 | 353 | 8785 |
Ching-Hsue Cheng | 42 | 209 | 8222 |
Saad M. Alshehri | 42 | 280 | 6179 |
Roman Dabrowski | 38 | 469 | 6415 |
Daniel Jun | 37 | 287 | 5505 |
Susheel Kalia | 36 | 105 | 6984 |
Dragan Pamučar | 36 | 194 | 4519 |
Turgay Celik | 35 | 508 | 5417 |
Janice D. Yoder | 33 | 81 | 3486 |
Miodrag Čolić | 32 | 212 | 3894 |
T. C. T. Ting | 32 | 121 | 9662 |
Manuela Tvaronavičienė | 31 | 153 | 2832 |