Institution
MIND Institute
About: MIND Institute is a based out in . It is known for research contribution in the topics: Autism & Population. The organization has 758 authors who have published 991 publications receiving 49514 citations. The organization is also known as: UC Davis MIND Institute & MIND Institute.
Papers published on a yearly basis
Papers
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New York University1, Nathan Kline Institute for Psychiatric Research2, MIND Institute3, Katholieke Universiteit Leuven4, University of Utah5, Yale University6, University of California, Los Angeles7, Massachusetts Institute of Technology8, Trinity College, Dublin9, Carnegie Mellon University10, Ben-Gurion University of the Negev11, Ludwig Maximilian University of Munich12, Oregon Health & Science University13, California Institute of Technology14, Indiana University15, San Diego State University16, University of Groningen17, Netherlands Institute for Neuroscience18, University of Wisconsin-Madison19, Cornell University20, University of Pittsburgh21, Stanford University22, University of Michigan23, Kennedy Krieger Institute24, Johns Hopkins University25
TL;DR: W Whole-brain analyses reconciled seemingly disparate themes of both hypo- and hyperconnectivity in the ASD literature; both were detected, although hypoconnectivity dominated, particularly for corticocortical and interhemispheric functional connectivity.
Abstract: Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires large-scale multidisciplinary efforts. Although the field of genetics has pioneered data sharing for these reasons, neuroimaging had not kept pace. In response, we introduce the Autism Brain Imaging Data Exchange (ABIDE)-a grassroots consortium aggregating and openly sharing 1112 existing resting-state functional magnetic resonance imaging (R-fMRI) data sets with corresponding structural MRI and phenotypic information from 539 individuals with ASDs and 573 age-matched typical controls (TCs; 7-64 years) (http://fcon_1000.projects.nitrc.org/indi/abide/). Here, we present this resource and demonstrate its suitability for advancing knowledge of ASD neurobiology based on analyses of 360 male subjects with ASDs and 403 male age-matched TCs. We focused on whole-brain intrinsic functional connectivity and also survey a range of voxel-wise measures of intrinsic functional brain architecture. Whole-brain analyses reconciled seemingly disparate themes of both hypo- and hyperconnectivity in the ASD literature; both were detected, although hypoconnectivity dominated, particularly for corticocortical and interhemispheric functional connectivity. Exploratory analyses using an array of regional metrics of intrinsic brain function converged on common loci of dysfunction in ASDs (mid- and posterior insula and posterior cingulate cortex), and highlighted less commonly explored regions such as the thalamus. The survey of the ABIDE R-fMRI data sets provides unprecedented demonstrations of both replication and novel discovery. By pooling multiple international data sets, ABIDE is expected to accelerate the pace of discovery setting the stage for the next generation of ASD studies.
1,939 citations
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TL;DR: This protocol provides guidelines for reproducible DTI-based tract-specific quantification for reconstructing major white matter tracts based on diffusion tensor imaging.
1,522 citations
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TL;DR: A comprehensive voxel-based examination of the impact of motion on the BOLD signal suggests that positive relationships may reflect neural origins of motion while negative relationships are likely to originate from motion artifact.
1,300 citations
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TL;DR: An overview of current knowledge and prevailing hypotheses regarding the conformational, oligomerization and aggregation states of α-syn and their role in regulating α- synuclein function in health and disease is provided.
Abstract: Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases. The molecular mechanism (or mechanisms) through which α-syn abnormally accumulates and contributes to neurodegeneration in these disorders remains unknown. Here, we provide an overview of current knowledge and prevailing hypotheses regarding the conformational, oligomerization and aggregation states of α-syn and their role in regulating α-syn function in health and disease. Understanding the nature of the various α-syn structures, how they are formed and their relative contributions to α-syn-mediated toxicity may inform future studies aiming to develop therapeutic prevention and intervention.
1,281 citations
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MIND Institute1, École Polytechnique Fédérale de Lausanne2, Technical University of Madrid3, Spanish National Research Council4, Howard Hughes Medical Institute5, Hebrew University of Jerusalem6, Imperial College London7, Yale University8, University of Debrecen9, King Juan Carlos University10, Karolinska Institutet11, University of Nottingham12, Wenzhou Medical College13, Tufts University14
TL;DR: A first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat is presented, finding a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms.
1,252 citations
Authors
Showing all 758 results
Name | H-index | Papers | Citations |
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Nancy C. Andreasen | 138 | 604 | 73175 |
Jean-Pierre Changeux | 138 | 672 | 76462 |
Vince D. Calhoun | 117 | 1234 | 62205 |
David G. Amaral | 112 | 302 | 49094 |
Jacqueline N. Crawley | 109 | 384 | 45205 |
Adrian M. Owen | 107 | 452 | 51298 |
Randi J Hagerman | 106 | 592 | 37643 |
Tomáš Paus | 105 | 467 | 49552 |
Michael P. Milham | 99 | 317 | 42144 |
Sally J. Rogers | 98 | 252 | 36033 |
F. Xavier Castellanos | 96 | 236 | 42904 |
Pierre J. Magistretti | 94 | 443 | 36830 |
Paul J. Hagerman | 93 | 281 | 26411 |
Irva Hertz-Picciotto | 88 | 412 | 26487 |
Henry Markram | 86 | 258 | 38054 |