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01 May 2000TL;DR: The use of CCR5 antagonists of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is -C(R13)2-, -C (R13)(R13), R19)-, -c(O)-, O-, -NH-, -N(alkyl)-, (a), (b), (c), (d), (e), (f), (g, (h), (h, (i), (j), (k, (k), (l), (m), (n) or (n
Abstract: The use of CCR5 antagonists of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is -C(R13)2-, -C(R13)(R19)-, -C(O)-, -O-, -NH-, -N(alkyl)-, (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m) or (n); R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is H, alkyl or alkenyl; R2 is optionally substituted phenyl, phenylalkyl, heteroaryl or heteroarylalkyl, naphthyl, fluorenyl or diphenylmethyl; R3 is optionally substituted phenyl, heteroaryl or naphthyl; R4 is H, alkyl, fluoro-alkyl, cyclopropylmethyl, -CH2CH2OH, -CH2CH2-O-alkyl, -CH2C(O)-O-alkyl, -CH2C(O)NH2, -CH2C(O)-NHalkyl or -CH2C(O)-N(alkyl)2; R19 is optionally substituted phenyl, heteroaryl or naphthyl, cycloalkyl, cycloalkylalkyl or alkoxyalkyl; and R5, R13, R14, R15 and R16 are hydrogen or alkyl for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.
223 citations
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05 Mar 2002TL;DR: In this paper, a method and system for performing sequence time domain reflectometry to determine the location of line anomalies in a communication channel is disclosed, and the system performs signal analysis of the correlated signal to determine a time value between the start of the reflection signal and the subsequent points of correlation.
Abstract: A method and system for performing sequence time domain reflectometry to determine the location of line anomalies in a communication channel is disclosed. In one embodiment, the system generates a sequence signal (1202) and transmits the sequence signal over a channel that is the subject of the sequence time domain reflectometry analysis (1212). The reflection signal is then received (1214) and correlated with the original sequence signal (1222) to generate a correlated signal. The system performs signal analysis of the correlated signal to determine a time value between the start of the reflection signal and the subsequent points of correlation. Based on the time value and the rate of propagation of the signals through the channel, the reflection-processing module can determine a distance from the system to a line anomaly (1230).
199 citations
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27 Aug 2003TL;DR: In this paper, a method of switching a first gateway from a voice mode to a facsimile mode comprises configuring the first gateway to the voice mode for communication with a second gateway over a packet network.
Abstract: According to one aspect, a method of switching a first gateway from a voice mode to a facsimile mode comprises: configuring the first gateway to the voice mode for communication with a second gateway over a packet network, receiving a plurality of data packets from the second gateway over the packet network, analyzing one or more of the plurality of data packets, such as UDP packets, and configuring the first gateway to the facsimile mode if the analyzing determines that the one or more of the plurality of data packets carry facsimile data packets. The analyzing may include calculating a length of the UDP payload in accordance with UDPTL packet structure, and deciding the UDP payload includes a UDPTL packet if the calculated length is equal to UDP payload length, as indicated in the UDP header.
156 citations
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15 Sep 2000TL;DR: In this paper, a speech compression system capable of encoding a speech signal into a bitstream for subsequent decoding to generate synthesized speech is disclosed, which optimizes the bandwidth consumed by the bitstream by balancing the desired average bit rate with the perceptual quality of the reconstructed speech.
Abstract: A speech compression system capable of encoding a speech signal into a bitstream for subsequent decoding to generate synthesized speech is disclosed. The speech compression system optimizes the bandwidth consumed by the bitstream by balancing the desired average bit rate with the perceptual quality of the reconstructed speech. The speech compression system comprises a full-rate codec, a half-rate codec, a quarter-rate codec and an eighth-rate codec. The codecs are selectively activated based on a rate selection. In addition, the full and half-rate codecs are selectively activated based on a type classification. Each codec is selectively activated to encode and decode the speech signals at different bit rates emphasizing different aspects of the speech signal to enhance overall quality of the synthesized speech.
119 citations
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25 Jun 2009TL;DR: In this article, an endpointer determines the background energy of a first portion of a speech signal, and a cepstral computing module extracts one or more features of the first portion.
Abstract: According to a disclosed embodiment, an endpointer determines the background energy of a first portion of a speech signal, and a cepstral computing module extracts one or more features of the first portion. The endpointer calculates an average distance of the first portion based on the features. Subsequently, an energy computing module measures the energy of a second portion of the speech signal, and the cepstral computing module extracts one or more features of the second portion. Based on the features of the second portion, the endpointer calculates a distance of the second portion. Thereafter, the endpointer contrasts the energy of the second portion with the background energy of the first portion, and compares the distance of the second portion with the distance of the first portion. The second portion of the speech signal is classified by the endpointer as speech or non-speech based on the contrast and the comparison.
111 citations
Authors
Showing all 274 results
Name | H-index | Papers | Citations |
---|---|---|---|
Khaled Assaleh | 27 | 120 | 2703 |
Huan-Yu Su | 25 | 66 | 2231 |
Eyal Shlomot | 18 | 27 | 845 |
Adil Benyassine | 17 | 27 | 839 |
Sverrir Olafsson | 16 | 45 | 661 |
Ragnar H. Jonsson | 16 | 35 | 924 |
Jes Thyssen | 15 | 24 | 942 |
Claude Lamblin | 15 | 71 | 1389 |
Warner B. Andrews | 14 | 24 | 537 |
P. Michael Henderson | 13 | 22 | 560 |
Adil Benyassine | 13 | 25 | 530 |
A.W.G. Duller | 13 | 43 | 676 |
Dominique Massaloux | 12 | 30 | 496 |
Yang Gao | 11 | 19 | 580 |
Sahar E. Bou-Ghazale | 11 | 17 | 885 |