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Institution

Mines ParisTech

EducationParis, France
About: Mines ParisTech is a education organization based out in Paris, France. It is known for research contribution in the topics: Finite element method & Microstructure. The organization has 6564 authors who have published 11676 publications receiving 359898 citations. The organization is also known as: École nationale supérieure des mines de Paris & École des mines de Paris.


Papers
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Journal ArticleDOI
01 Sep 2012-RNA
TL;DR: This work hypothesize a model in which all proposed mechanisms of microRNA action coexist, and where the apparent mechanism that is detected in a given experiment is determined by the relative values of the intrinsic characteristics of the target mRNAs and associated biological processes.
Abstract: MicroRNAs (miRNAs) are key regulators of all important biological processes, including development, differentiation, and cancer. Although remarkable progress has been made in deciphering the mechanisms used by miRNAs to regulate translation, many contradictory findings have been published that stimulate active debate in this field. Here we contribute to this discussion in three ways. First, based on a comprehensive analysis of the existing literature, we hypothesize a model in which all proposed mechanisms of microRNA action coexist, and where the apparent mechanism that is detected in a given experiment is determined by the relative values of the intrinsic characteristics of the target mRNAs and associated biological processes. Among several coexisting miRNA mechanisms, the one that will effectively be measurable is that which acts on or changes the sensitive parameters of the translation process. Second, we have created a mathematical model that combines nine known mechanisms of miRNA action and estimated the model parameters from the literature. Third, based on the mathematical modeling, we have developed a computational tool for discriminating among different possible individual mechanisms of miRNA action based on translation kinetics data that can be experimentally measured (kinetic signatures). To confirm the discriminatory power of these kinetic signatures and to test our hypothesis, we have performed several computational experiments with the model in which we simulated the coexistence of several miRNA action mechanisms in the context of variable parameter values of the translation.

133 citations

Journal ArticleDOI
Bruno Latour1
TL;DR: The authors explores the specificty of this regime and especially the strange link it has with the canonical definition of enunciation in linguistics and semiotics, and thus also the reasons why a 'transparent' or 'rational' political speech act destroys the very conditions of group formation.
Abstract: Political enunciation remains an enigma as long as it is considered from the standpoint of information transfer. It remains as unintelligible as religious talk. The paper explores the specificty of this regime and especially the strange link it has with the canonical definition of enunciation in linguistics and semiotics. The ‘political circle’ is reconstituted and thus also the reasons why a ‘transparent’ or ‘rational'political speech act destroys the very conditions of group formation.

133 citations

Journal ArticleDOI
G. Royer1
TL;DR: In this article, the potential barrier against α-decay or α-capture has been determined within a liquid drop model including a proximity energy term, and simple expressions are provided to calculate the possible barrier radius and height.

133 citations

Proceedings ArticleDOI
04 May 2003
TL;DR: It is shown that the simple comparison of the RGB components taken two by two is sufficient to segment road signs in real-time, and from this segmentation it should be much easier to identify the shape (and meaning) of a particular sign.
Abstract: This subject is part of a more challenging research project aimed at developing a computer vision system, embedded in a car, and capable of identifying and locating road signs. Several constraints limit the possible solutions are first identified. For instance in such an application, we definitely need a real-time system; in addition, we wish to limit our choice to a single camera methodology to keep the hardware as simple as possible and finally our approach must work efficiently on low cost hardware. For this purpose we first rely on a color segmentation strategy to recognize the road signs. We have studied the behavior of the RGB components of several road signs from sunrise to sunset. From these results we have shown that the simple comparison of the RGB components taken two by two is sufficient to segment road signs in real-time. From this segmentation it should be much easier to identify the shape (and meaning) of a particular sign.

132 citations


Authors

Showing all 6591 results

NameH-indexPapersCitations
Francis Bach11048454944
Olivier Delattre10349039258
Richard M. Murray9771169016
Bruno Latour9636494864
George G. Malliaras9438228533
George S. Wilson8871633034
Zhong-Ping Jiang8159724279
F. Liu8042823869
Kazu Suenaga7532926287
Carlo Adamo7544436092
Edith Heard7519623899
Enrico Zio73112723809
John J. Jonas7037921544
Bernard Asselain6940923648
Eric Guibal6929416397
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202315
202264
2021274
2020260
2019250
2018249