Mines ParisTech

About: Mines ParisTech is a education organization based out in Paris, France. It is known for research contribution in the topics: Finite element method & Microstructure. The organization has 6564 authors who have published 11676 publications receiving 359898 citations. The organization is also known as: École nationale supérieure des mines de Paris & École des mines de Paris.

Operating an atom interferometer beyond its linear range

Abstract: In this paper, we show that an atom interferometer inertial sensor, when associated with the auxiliary measurement of external vibrations, can be operated beyond its linear range and still keep a high acceleration sensitivity. We propose and compare two measurement procedures (fringe fitting and non-linear lock) that can be used to extract, without adding any bias, the mean phase of the interferometer when the interferometer phase fluctuations exceed 2?. Despite operating in the urban environment of inner Paris without any vibration isolation, the use of a low noise seismometer for the measurement of ground vibrations allows our atom gravimeter to reach at night a sensitivity as good as 5.5 ? 10?8g at 1?s. Robustness of the measurement to large vibration noise is also demonstrated by the ability of our gravimeter to operate during an earthquake with excellent sensitivity. For such low vibration frequency though, high pass filtering of the seismometer degrades its correlation with the interferometer signal, so that low frequency seismic vibrations appear on the gravity measurement. Nevertheless, our high repetition rate allows for efficient sampling of these perturbations, ensuring proper averaging. Such techniques open new perspectives for applications in other fields, such as navigation and geophysics.

Virtual screening of GPCRs: an in silico chemogenomics approach.

Abstract: The G-protein coupled receptor (GPCR) superfamily is currently the largest class of therapeutic targets. In silico prediction of interactions between GPCRs and small molecules in the transmembrane ligand-binding site is therefore a crucial step in the drug discovery process, which remains a daunting task due to the difficulty to characterize the 3D structure of most GPCRs, and to the limited amount of known ligands for some members of the superfamily. Chemogenomics, which attempts to characterize interactions between all members of a target class and all small molecules simultaneously, has recently been proposed as an interesting alternative to traditional docking or ligand-based virtual screening strategies.

A hardware implementation of pure ESTEREL

Abstract: esterel is a synchronous concurrent programming language dedicated to reactive systems (controllers, protocols, man-machine interfaces etc.). esterel has an efficient standard software implementation based on well-defined mathematical semantics. We present a new hardware implementation of the pure synchronization subset of the language. Each program generates a specific circuit that responds to any input in one clock cycle. When the source program satisfies some statically checkable dynamic properties, the circuit is shown to be semantically equivalent to the source program. The hardware translation has been effectively implemented on the programmable active memory perle0 developed by J Vuillemin and his group at Digital Equipment.