Institution
Mines ParisTech
Education•Paris, France•
About: Mines ParisTech is a education organization based out in Paris, France. It is known for research contribution in the topics: Finite element method & Microstructure. The organization has 6564 authors who have published 11676 publications receiving 359898 citations. The organization is also known as: École nationale supérieure des mines de Paris & École des mines de Paris.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors introduce new environmental constraints, namely carbon emission constraints, in multi-sourcing lot-sizing problems, which aim at limiting the carbon emission per unit of product supplied with different modes.
209 citations
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TL;DR: In this paper, a review of international patent data at a detailed technology level with field interviews of ten Chinese PV companies was conducted to understand the drivers of this success and its limits, with a particular emphasis on the role of technology transfers and innovation.
208 citations
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TL;DR: A global computation model for self-wiping corotating twin screw extruders based on a 1D approximated approach that allows one to obtain, for any screw profile, the profile along the screws of the main flow variables, such as pressure, mean temperature, residence time, and filling ratio.
Abstract: A global computation model for self-wiping corotating twin screw extruders is proposed. Based on a 1D approximated approach, it has been validated by comparison with experimentation and more sophisticated numerical models. It allows one to obtain, for any screw profile including left-and right-handed screw elements and kneading discs, the profile along the screws of the main flow variables, such as pressure, mean temperature, residence time, and filling ratio. Owing to the approximations made, this model can be easily and rapidly run on a personal computer or a workstation. Important applications may be found in screw profile design, scaleup, compounding or reactive extrusion.
207 citations
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01 Jan 2006207 citations
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TL;DR: The results are indicative of a strong association between the P. falciparum spatial genome organization and gene expression, and the molecular processes involved in genome conformation dynamics could contribute to the discovery of novel antimalarial strategies.
Abstract: The development of the human malaria parasite Plasmodium falciparum is controlled by coordinated changes in gene expression throughout its complex life cycle, but the corresponding regulatory mechanisms are incompletely understood. To study the relationship between genome architecture and gene regulation in Plasmodium, we assayed the genome architecture of P. falciparum at three time points during its erythrocytic (asexual) cycle. Using chromosome conformation capture coupled with next-generation sequencing technology (Hi-C), we obtained high-resolution chromosomal contact maps, which we then used to construct a consensus three-dimensional genome structure for each time point. We observed strong clustering of centromeres, telomeres, ribosomal DNA, and virulence genes, resulting in a complex architecture that cannot be explained by a simple volume exclusion model. Internal virulence gene clusters exhibit domain-like structures in contact maps, suggesting that they play an important role in the genome architecture. Midway during the erythrocytic cycle, at the highly transcriptionally active trophozoite stage, the genome adopts a more open chromatin structure with increased chromosomal intermingling. In addition, we observed reduced expression of genes located in spatial proximity to the repressive subtelomeric center, and colocalization of distinct groups of parasite-specific genes with coordinated expression profiles. Overall, our results are indicative of a strong association between the P. falciparum spatial genome organization and gene expression. Understanding the molecular processes involved in genome conformation dynamics could contribute to the discovery of novel antimalarial strategies.
207 citations
Authors
Showing all 6591 results
Name | H-index | Papers | Citations |
---|---|---|---|
Francis Bach | 110 | 484 | 54944 |
Olivier Delattre | 103 | 490 | 39258 |
Richard M. Murray | 97 | 711 | 69016 |
Bruno Latour | 96 | 364 | 94864 |
George G. Malliaras | 94 | 382 | 28533 |
George S. Wilson | 88 | 716 | 33034 |
Zhong-Ping Jiang | 81 | 597 | 24279 |
F. Liu | 80 | 428 | 23869 |
Kazu Suenaga | 75 | 329 | 26287 |
Carlo Adamo | 75 | 444 | 36092 |
Edith Heard | 75 | 196 | 23899 |
Enrico Zio | 73 | 1127 | 23809 |
John J. Jonas | 70 | 379 | 21544 |
Bernard Asselain | 69 | 409 | 23648 |
Eric Guibal | 69 | 294 | 16397 |