Mississippi State University

About: Mississippi State University is a education organization based out in Starkville, Mississippi, United States. It is known for research contribution in the topics: Population & Catfish. The organization has 14115 authors who have published 28594 publications receiving 700030 citations. The organization is also known as: The Mississippi State University of Agriculture and Applied Science & Mississippi State University of Agriculture and Applied Science.

Dynamics of global transcriptome in bovine matured oocytes and preimplantation embryos

Abstract: Global activation of the embryonic genome is the most critical event in early mammalian development. After fertilization, a rich supply of maternal proteins and RNAs support development whereas a number of zygotic and embryonic genes are expressed in a stage-specific manner leading to embryonic genome activation (EGA). However, the identities of embryonic genes expressed and the mechanism(s) of EGA are poorly defined in the bovine. Using the Affymetrix bovine-specific DNA microarray as the biggest available array at present, we analyzed gene expression at two key stages of bovine development, matured oocytes (MII) and 8-cell-stage embryos, constituting the ultimate reservoir for life and a stage during which EGA takes place, respectively. Key genes in regulation of transcription, chromatin-structure cell adhesion, and signal transduction were up-regulated at the 8-cell stage as compared with 8-cell embryos treated with α-amanitin and MII. Genes controlling DNA methylation and metabolism were up-regulated in MII. These changes in gene expression, related to transcriptional machinery, chromatin structure, and the other cellular functions occurring during several cleavage stages, are expected to result in a unique chromatin structure capable of maintaining totipotency during embryogenesis and leading to differentiation during postimplantation development. Dramatic reprogramming of gene expression at the onset of development also has implications for cell plasticity in somatic cell nuclear transfer, genomic imprinting, and cancer.

Distinguishing Mediational Models and Analyses in Clinical Psychology: Atemporal Associations Do Not Imply Causation.

Abstract: Purpose A popular way to attempt to discern causality in clinical psychology is through mediation analysis. However, mediation analysis is sometimes applied to research questions in clinical psychology when inferring causality is impossible. This practice may soon increase with new, readily available, and easy-to-use statistical advances. Thus, we here provide a heuristic to remind clinical psychological scientists of the assumptions of mediation analyses. Approach We describe recent statistical advances and unpack assumptions of causality in mediation, underscoring the importance of time in understanding mediational hypotheses and analyses in clinical psychology. Example analyses demonstrate that statistical mediation can occur despite theoretical mediation being improbable. Conclusion We propose a delineation of mediational effects derived from cross-sectional designs into the terms temporal and atemporal associations to emphasize time in conceptualizing process models in clinical psychology. The general implications for mediational hypotheses and the temporal frameworks from within which they may be drawn are discussed.

Weather Index Insurance and Climate Change: Opportunities and Challenges in Lower Income Countries

Abstract: Weather index insurance underwrites a weather risk, typically highly correlated with agricultural production losses, as a proxy for economic loss and is gaining popularity in lower income countries. This instrument, although subject to basis risk and high start-up costs, should reduce costs over traditional agricultural insurance. Multilateral institutions have suggested that weather index insurance could enhance the ability of stakeholders in lower income countries to adapt to climate change. While weather index insurance could have several benefits in this context (e.g. providing a safety net to vulnerable households and price signals regarding the weather risk), climate change impacts increase the price of insurance due to increasing weather risk. Uncertainty about the extent of regional impacts compounds pricing difficulties. Policy recommendations for insurance market development include funding risk assessments, start-up costs and the extreme layer of risk. General premium subsidies are cautioned against as they may actually slow household adaptation.

Loci: a rule-based framework for parallel multi-disciplinary simulation synthesis

Abstract: We present a rule-based framework for the development of scalable parallel high performance simulations for a broad class of scientific applications (with particular emphasis on continuum mechanics). We take a pragmatic approach to our programming abstractions by implementing structures that are used frequently and have common high performance implementations on distributed memory architectures. The resulting framework borrows heavily from rule-based systems for relational database models, however limiting the scope to those parts that have obvious high performance implementation. Using our approach, we demonstrate predictable performance behavior and efficient utilization of large scale distributed memory architectures on problems of significant complexity involving multiple disciplines.

Grid Generation Techniques in Computational Fluid Dynamics

Abstract: Revue des differentes methodes. On montre que les regions tridimensionnelles sont mieux traitees par fragmentation du champ en sous-regions avec generation de grilles dans chaque sous-region. Interet des grilles adaptatives couplees a des solutions physiques