Mitre Corporation

About: Mitre Corporation is a company organization based out in Bedford, Massachusetts, United States. It is known for research contribution in the topics: Air traffic control & National Airspace System. The organization has 4884 authors who have published 6053 publications receiving 124808 citations. The organization is also known as: Mitre & MITRE.

Cancellation of specular and diffuse jammer multipath using a hybrid adaptive array

Abstract: It has been demonstrated that specular or diffuse jammer multipath can be canceled to a desired level by using an adaptive array that combines bandwidth partitioning with tapped delay lines. Such hybrid systems are studied. In particular, the author studies an ideal two-element array that uses bandwidth partitioning in both the main and auxiliary channels, with an Mth-order adaptive finite impulse response filter in each subband of the auxiliary. The ability of this system to cancel specular moderately diffuse and diffuse multipath is studied. The combinations of bandwidth partitioning and filter order that can achieve a specified jammer cancellation level are discussed. >

Semantic Web and Big Data meets Applied Ontology: The Ontology Summit 2014

Abstract: Leo Obrst a,∗, Michael Gruninger b, Ken Baclawski c, Mike Bennett d, Dan Brickley e, Gary Berg-Cross f, Pascal Hitzler g, Krzysztof Janowicz h, Christine Kapp i, Oliver Kutz j, Christoph Lange k, Anatoly Levenchuk l, Francesca Quattri m, Alan Rector n, Todd Schneider o, Simon Spero p, Anne Thessen q, Marcela Vegetti r, Amanda Vizedom s, Andrea Westerinen t, Matthew West u and Peter Yim v a The MITRE Corporation, McLean, VA, USA b University of Toronto, Toronto, Canada c Northeastern University, Boston, MA, USA d Hypercube Ltd., London, UK e Google, London, UK f Knowledge Strategies, Washington, DC, USA g Wright State University, Dayton, OH, USA h University of California, Santa Barbara, Santa Barbara, CA, USA i JustIntegration, Inc., Kissimmee, FL, USA j Otto von Guericke University Magdeburg, Magdeburg, Germany k University of Bonn, Bonn, Germany; Fraunhofer IAIS, Sankt Augustin, Germany l TechInvestLab.ru, Moscow, Russia m The Hong Kong Polytechnic University, Hong Kong n University of Manchester, Manchester, UK o PDS, Inc., Arvada, CO, USA p University of North Carolina, Chapel Hill, NC, USA q Arizona State University, Phoenix, AZ, USA r INGAR (CONICET/UTN), Santa Fe, Argentina s Criticollab, LLC, Durham, NC, USA t Nine Points Solutions, LLC, Potomac, MD, USA u Information Junction, Fareham, UK v CIM Engineering, Inc., San Mateo, CA, USA

2.1.3 Engineering Enterprises Using Complex-System Engineering

Abstract: This paper summarizes a complex-system engineering (cSE) regimen for the deliberate and accelerated management of the natural processes that shape the development of complex-systems and proposes an approach for applying this regimen to enterprises. It also introduces a fundamental process of cSE, multiscale analysis—a departure from the traditional, uniscale, reductionist analysis that underpins traditional system engineering (TSE).

Alterations in gene expression in Caenorhabditis elegans associated with organophosphate pesticide intoxication and recovery

Abstract: The principal toxicity of acute organophosphate (OP) pesticide poisoning is the disruption of neurotransmission through inhibition of acetylcholinesterase (AChE). However, other mechanisms leading to persistent effects and neurodegeneration remain controversial and difficult to detect. Because Caenorhabditis elegans is relatively resistant to OP lethality—particularly through the inhibition of AChE—studies in this nematode provide an opportunity to observe alterations in global gene expression following OP exposure that cannot be readily observed in less resistant organisms. We exposed cultures of worms in axenic, defined medium to dichlorvos under three exposure protocols. In the first, worms were exposed continuously throughout the experiment. In the second and third, the worms were exposed for either 2 or 8 h, the dichlorvos was washed out of the culture, and the worms were allowed to recover. We then analyzed gene expression using whole genome microarrays from RNA obtained from worms sampled at multiple time points throughout the exposure. The worms showed a time-dependent increase in the expression of genes involved in stress responses. Early in the exposure, the predominant effect was on metabolic processes, while at later times, an immune-like response and cellular repair mechanisms dominated the expression pattern. Following removal of dichlorvos, the gene expression in the worms appeared to relatively rapidly return to steady-state levels. The changes in gene expression observed in the worms following exposure to dichlorvos point towards two potential mechanisms of toxicity: inhibition of AChE and mitochondrial disruption.