Mitsubishi

About: Mitsubishi is a company organization based out in Tokyo, Japan. It is known for research contribution in the topics: Layer (electronics) & Signal. The organization has 53115 authors who have published 54821 publications receiving 870150 citations. The organization is also known as: Mitsubishi Group of Companies & Mitsubishi Companies.

The role of the pineal organ and the suprachiasmatic nucleus in the control of circadian locomotor rhythms in the Java sparrow, Padda oryzivora

Abstract: The roles of the pineal organ and the suprachiasmatic nucleus (SCN) in the control of circadian rhythms of locomotor activity were examined in male Java sparrows (Padda oryzivora). 1. Removal of the pineal organ resulted in (i) no interference with entrainment to a light-dark (LD) cycle with anticipatory activity, (ii) appearance of residual circadian rhythmicity for a while after transfer from an LD cycle to a continuous dim light condition (LL), and (iii) subsequent loss of the circadian locomotor rhythms in prolonged LL (Fig. 1). 2. Birds with bilateral SCN lesions showed diurnal rhythms with anticipatory activity in LD cycles, but did not show any circadian rhythms in LL (Fig. 2). Unilateral lesions of the SCN did not lead to loss of circadian rhythms in LL. The length of the circadian period (τ), however, changed for about a month. 3. Continuous administration of melatonin induced suppression of the circadian activity rhythms and reduced total amount of locomotor activity in LL (Fig. 3).

Bottom-up genome assembly using the Bacillus subtilis genome vector

Abstract: We established a protocol to construct complete recombinant genomes from their small contiguous DNA pieces and obtained the genomes of mouse mitochondrion and rice chloroplast using a B. subtilis genome (BGM) vector. This method allows the design of any recombinant genomes, valuable not only for fundamental research in systems biology and synthetic biology but also for various applications in the life sciences.

A microwave miniaturized linearizer using a parallel diode with a bias feed resistance

Abstract: A miniaturized linearizer using a parallel diode with a bias feed resistance has been proposed. The linearizer has positive gain and negative phase deviations and can be used as a linearizer for power amplifiers. These characteristics are provided by a nonlinearity of the diode and movement of bias point caused by a voltage drop at the bias feed resistance. By applying this linearizer to an S-band power amplifier, improvement of adjacent channel leakage power of 5 dB and improvement of power-added efficiency of 8.5% have been achieved for the /spl pi//4-shift QPSK modulated signal.

Dystonia with motor delay in compound heterozygotes for GTP-cyclohydrolase I gene mutations

Abstract: Mutations in the GTP-cyclohydrolase I (GCH) gene have been identified as a cause of two disorders: autosomal dominant hereditary progressive dystonia/dopa-responsive dystonia (HPD/DRD) and autosomal recessive GCH-deficient hyperphenylalaninemia (HPA). Detailed clinical descriptions and genetic analysis of patients with phenotypes intermediate between HPD/DRD (mild) and GCH-deficient HPA (severe) have not been reported. We conducted genomic DNA sequencing of the GCH gene in two patients (Cases 1 and 2) manifesting generalized dystonia responsive to levodopa and severe developmental motor delay. In the pedigree of Patient 1, there were HPD/DRD patients in three generations preceding the index case. Patients 1 and 2 were compound heterozygotes with maternally and paternally transmitted mutations in the coding region of the GCH gene. In both compound heterozygotes, tetrahydrobiopterin (BH4) levels in cerebrospinal fluid were lower than those in HPD/DRD. Administration of BH4, in addition to levodopa, further improved the symptomatology of Patient 1. Our data demonstrate a new phenotype of GCH deficiency associated with compound heterozygosity for GCH gene mutations and suggest the usefulness of combined BH4 and levodopa therapy for this disorder.