Institution
Mitsubishi
Company•Tokyo, Japan•
About: Mitsubishi is a company organization based out in Tokyo, Japan. It is known for research contribution in the topics: Signal & Layer (electronics). The organization has 53115 authors who have published 54821 publications receiving 870150 citations. The organization is also known as: Mitsubishi Group of Companies & Mitsubishi Companies.
Topics: Signal, Layer (electronics), Semiconductor memory, Electrode, Voltage
Papers published on a yearly basis
Papers
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01 Jun 1982-Journal of Comparative Physiology A-neuroethology Sensory Neural and Behavioral Physiology
TL;DR: The results suggest an endogenous nature of the circadian rhythm of the SCN within the hypothalamic island, which may have not only an inherent ability to generate a circadian rhythm, but also an intricate machinery to regulate its phase.
Abstract: The nature of the circadian rhythms of the SCN in a hypothalamic island was examined in male rats by recording multiple unit activity from the SCN for longer durations. Successful continuous recording lasted up to 35 days. Neural activity of the SCN inside the island showed free-running rhythms whose periods were slightly longer than 24 h (Figs. 2, 3, Table 1). When the retino-hypothalamic pathway was spared, re-entrainment to a displaced light and dark cycle was attained following a transition period of a few days (Fig. 4). Phases of the rhythms shifted in a phase-dependent manner in response to single light pulses interrupting constant darkness (Fig. 5 and Fig. 6). These results suggest an endogenous nature of the circadian rhythm of the SCN within the hypothalamic island. Thus, neurons or neuronal networks in the SCN may have not only an inherent ability to generate a circadian rhythm, but also an intricate machinery to regulate its phase. Simultaneous recordings from the left and right SCN showed a slight but visible discrepancy in their phases between the two rhythms in 3 out of 12 cases (Fig. 7).
216 citations
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TL;DR: Two-dimensional phosphopeptide mapping using mutation of phosphorylation sites for MAPK revealed that the nine serine residues in Foxo1 are specifically phosphorylated by Erk and p38, and that this phosphorylations regulates the function of Foxo 1 as a coactivator for Ets-1.
215 citations
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TL;DR: The results show that the loss of tau protein may itself lead to some of the neurological characteristics observed in FTDP-17 patients, including muscle weakness in the wire-hanging test and a tendency to fall more easily in the rod-walking test.
215 citations
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23 Dec 1983TL;DR: In this paper, a rear projection screen has a front surface receiving light rays from a projector and a viewing surface formed with a lenticulated surface in which lenticules each consisting of a crest, a trough and a flank interconnecting the crest and trough are continuously laid.
Abstract: Provided is a rear projection screen having a front surface receiving light rays from a projector and a viewing surface formed with a lenticulated surface in which lenticules each consisting of a crest, a trough and a flank interconnecting the crest and trough are continuously laid. The flank surface is provided with, on at least a part thereof, a total reflecting surface on which all light rays impinging thereto are reflected and then emanate from the crest through a medium interface thereof.
215 citations
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TL;DR: Assessing TnI72h after primary PCI is a simple, effective method to estimate infarct size, LVEF, and potentially useful for risk stratification.
Abstract: Objectives We sought to determine the best cardiac biomarker to predict infarct size, left ventricular ejection fraction (LVEF), and clinical outcome in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Background The cardiac biomarkers, creatine kinase (CK), CK-MB, and troponins T and I are routinely measured after myocardial infarction. However, their correlation with functional and clinical outcomes after PCI for STEMI is not well established. Methods In the EVOLVE (EValuation Of MCC-135 for Left VEntricular Salvage in Acute Myocardial Infarction) trial, patients were randomized to receive intracellular calcium modulator as adjunct to primary PCI for first large STEMI. Cardiac biomarker levels were determined in 378 patients before PCI and serially up to 72 h. Single-photon emission computed tomography was performed after 5 and 30 days, and patients were monitored up to 180 days. Results All single time-point, peak, and area under time-concentration curve of CK, CK-MB, and troponins T and I after PCI significantly correlated with infarct size and LVEF. In particular, 72-h troponin I (TnI72h) correlated strongly with 5-day and 30-day infarct size (r g 0.70; p l 0.001). A TnI72h threshold g55 ng/ml was 90% sensitive for large infarct size (≥10%) and low LVEF (≤40%) with specificities of 70% and 52%, respectively (c = 0.88, 0.81; p l 0.001). The highest TnI72h tertile was associated with increased 180-day composite clinical events (23% vs. 23% vs. 42%; p = 0.001) and independently predicted adverse events (hazard ratio = 2.3; p = 0.01). Conclusions Assessing TnI72h after primary PCI is a simple, effective method to estimate infarct size, LVEF, and potentially useful for risk stratification.
214 citations
Authors
Showing all 53117 results
Name | H-index | Papers | Citations |
---|---|---|---|
Thomas S. Huang | 146 | 1299 | 101564 |
Kazunari Domen | 130 | 908 | 77964 |
Kozo Kaibuchi | 129 | 493 | 60461 |
Yoshimi Takai | 122 | 680 | 61478 |
William T. Freeman | 113 | 432 | 69007 |
Tadayuki Takahashi | 112 | 932 | 57501 |
Takashi Saito | 112 | 1041 | 52937 |
H. Vincent Poor | 109 | 2116 | 67723 |
Qi Tian | 96 | 1030 | 41010 |
Andreas F. Molisch | 96 | 777 | 47530 |
Takeshi Sakurai | 95 | 492 | 43221 |
Akira Kikuchi | 93 | 412 | 28893 |
Markus Gross | 91 | 588 | 32881 |
Eiichi Nakamura | 90 | 845 | 31632 |
Michael Wooldridge | 87 | 543 | 50675 |