Showing papers by "Monash University published in 1997"

Management control systems and strategy: A critical review☆

Abstract: This paper reviews research that studies the relationship between management control systems (MCS) and business strategy. Empirical research studies that use contingency approaches and case study applications are examined focusing on specific aspects of MCS and their relationship with strategy. These aspects include cost control orientation, performance evaluation and reward systems, the effect of resource sharing, the role of MCS in influencing strategic change and the choice of interactive and diagnostic controls. More contemporary approaches to the relationship between performance measurement systems and strategy are also considered. It is concluded that our knowledge of the relationship between MCS and strategy is limited, providing considerable scope for further research. A series of future research questions is presented.

Digital Signcryption or How to Achieve Cost(Signature & Encryption) << Cost(Signature) + Cost(Encryption)

Abstract: Secure and authenticated message delivery/storage is one of the major aims of computer and communication security research. The current standard method to achieve this aim is “(digital) signature followed by encryption”. In this paper, we address a question on the cost of secure and authenticated message delivery/storage, namely, whether it is possible to transport/store messages of varying length in a secure and authenticated way with an expense less than that required by “signature followed by encryption”. This question seems to have never been addressed in the literature since the invention of public key cryptography. We then present a positive answer to the question. In particular, we discover a new cryptographic primitive termed as “signcryption” which simultaneously fulfills both the functions of digital signature and public key encryption in a logically single step, and with a cost significantly lower than that required by “signature followed by encryption”. For typical security parameters for high level security applications (size of public moduli = 1536 bits), signcryption costs 50% (31%, respectively) less in computation time and 85% (91%, respectively) less in message expansion than does “signature followed by encryption” based on the discrete logarithm problem (factorization problem, respectively).

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

Abstract: The molecular mechanisms predisposing to atherosclerotic aneurysm formation remain undefined(1-5). Nevertheless, rupture of aortic aneurysms is a major cause of death in Western societies, with few available treatments and poor long-term prognosis. Indirect evidence suggests that matrix metalloproteinases (MMPs) and plasminogen activators (PAs) are involved in its pathogenesis (1,6-12). MMPs are secreted as inactive zymogens (pro-MMPs), requiring activation in the extracellular compartment(11,13). Plasmin, generated from the zymogen plasminogen by tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA; refs 14,15), has been proposed as a possible activator in vitro, but evidence for such a role in vivo is lacking(16,17) . Analysis of atherosclerotic aorta in mice with a deficiency of apoliprotein E (Apoe(-/-);ref. 18), singly or combined with a deficiency of t-PA (Apoe(-/-):Plat(-/-)) or of u-PA (Apoe(-/-):Plau(-/-); ref. 19), indicated that deficiency of u-PA protected against media destruction and aneurysm formation, probably by means of reduced plasmin-dependent activation of pro-MMPs. This genetic evidence suggests that plasmin is a pathophysiologically significant activator of pro-MMPs in vivo and may have implications for the design of therapeutic strategies to prevent aortic-wall destruction by controlling Plau gene function.

Archaic African and Asian lineages in the genetic ancestry of modern humans

Abstract: A 3-kb region encompassing the beta-globin gene has been analyzed for allelic sequence polymorphism in nine populations from Africa, Asia, and Europe. A unique gene tree was constructed from 326 sequences of 349 in the total sample. New maximum-likelihood methods for analyzing gene trees on the basis of coalescence theory have been used. The most recent common ancestor of the beta-globin gene tree is a sequence found only in Africa and estimated to have arisen approximately 800,000 years ago. There is no evidence for an exponential expansion out of a bottlenecked founding population, and an effective population size of approximately 10,000 has been maintained. Modest differences in levels of beta-globin diversity between Africa and Asia are better explained by greater African effective population size than by greater time depth. There may have been a reduction of Asian effective population size in recent evolutionary history. Characteristically Asian ancestry is estimated to be older than 200,000 years, suggesting that the ancestral hominid population at this time was widely dispersed across Africa and Asia. Patterns of beta-globin diversity suggest extensive worldwide late Pleistocene gene flow and are not easily reconciled with a unidirectional migration out of Africa 100,000 years ago and total replacement of archaic populations in Asia.

Influence of gender, parental health, and perceived expertise of assistance upon stress, anxiety, and depression among parents of children with autism

Abstract: A survey of 219 parents of children with autism was administered on a confidential and anonymous basis. As well as tapping information about the nature of the child's disorder, parental well-being (anxiety, depression), parents' daily level of stress arising from parenting, their confidence in handling their child's major difficulty, and the frequency of being stretched beyond their limits were included as dependent variables. Independent variables were: gender of parents, age of child and age of onset, parental health, access to other family members, and level of understanding of those family members of the child's problems. Data indicated that, although social support has previously been posited as an alleviating factor for parental stress, this may be a result of the perceived expertise of the family member who provides respite care for the parents. Issues of self-efficacy, training in behaviour management, and provision of home-based care for parents are discussed.

Small business use of the Internet: Findings from Australian case studies

Abstract: Internet use among small businesses has recently become a popular topic for researchers in the fields of marketing, information systems and entrepreneurship. In view of the media hype this topic has received over recent months, it is important for small businesses to learn from the experiences of early adopters of the Internet. Presents the results of a case study research involving 23 Australian small businesses which were early adopters of the Internet ‐ and which are still users. Finds that they are predominantly using the Internet as a communications medium and, to a lesser extent, as a document transfer and advertising channel. Management enthusiasm and perceived benefits seem to be the driving force for ongoing Internet use, although little or no integration was discovered between internal applications and Internet inter‐organizational functions. Findings also point to the importance of entrepreneurship for successful Internet use.

Scale interactions during the formation of typhoon irving

Abstract: The development of Typhoon Irving is investigated using a variety of data, including special research aircraft data from the Tropical Cyclone Motion (TCM-92) experiment, objective analyses, satellite data, and traditional surface and sounding data. The development process is treated as a dry-adiabatic vortex dynamics problem, and it is found that environmental and mesoscale dynamics mutually enhance each other in a cooperative interaction during cyclone formation. Synoptic-scale interactions result in the evolution of the hostile environment toward more favorable conditions for storm development. Mesoscale interactions with the low-level, large-scale circulations and with other midlevel, mesoscale features result in development of vorticity in the midlevels and enhancement of the low-level vorticity associated with the developing surface cyclone. Multiple developments of mesoscale convective systems after the storm reaches tropical depression strength suggests both an increase in low-level confluence and a tendency toward recurrent development of associated mesoscale convective vortices. This is observed in both aircraft data and satellite imagery where subsequent interactions, including mergers with the low-level, tropical depression vortex, are observed. A contour dynamics experiment suggests that the movement of mesoscale convective systems in satellite imagery corresponds well to the movement of their associated midlevel vortices. Results from a simple baroclinic experiment show that the midlevel vortices affect the large-scale, low-level circulation in two ways: 1) initially, interactions between midlevel vortices produce a combined vortex of greater depth; 2) interaction between midlevel vortices and the low-level circulation produces a development downward of the midlevel vorticity. This strengthens the surface vortex and develops a more cohesive vortex that extends from the surface through the midtroposphere.

Educating Australia: Government, Economy and Citizen since 1960

Abstract: 1. Introduction Part I. The Modern Citizen 1960-1975: 2. The expansion of education to 1975 3. The Karmel report and education equality Part II. The Anti-Citizen 1975-1990: 4. The New Right and public policy 5. Individual and government 6. The New Right and education Part III. The Economic Citizen 1985-: 7. Education and national economic reconstruction 8. Participation and equity 9. Economic government in education Part IV. The Multi-Citizen 1990-: 10. Civics, citizenship and difference.

Using improved genetic algorithms to facilitate time-cost optimization

Abstract: Time-cost optimization problems in construction projects are characterized by the constraints on the time and cost requirements. Such problems are difficult to solve because they do not have unique solutions. Typically, if a project is running behind the scheduled plan, one option is to compress some activities on the critical path so that the target completion time can be met. As combinatorial optimization problems, time-cost optimization problems are suitable for applying genetic algorithms (GAs). However, basic GAs may involve very large computational costs. This paper presents several improvements to basic GAs and demonstrates how these improved GAs reduce computational costs and significantly increase the efficiency in searching for optimal solutions.

Leber's hereditary optic neuropathy Biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype

Abstract: To clarify the bioenergetic relevance of mtDNA mutations in Leber's hereditary optic neuropathy (LHON), we investigated affected individuals and healthy carriers from six Italian LHON families harboring the 11778/ND4 and the 3460/ND1 mtDNA mutations. The enzymatic activities of mitochondrial complex I and its sensitivity to the potent inhibitors rotenone and rolliniastatin-2 were studied in mitochondrial particles from platelets, in correlation with mtDNA analysis of platelets and leukocytes. In platelets homoplasmic for mutant mtDNA, both 11778/ND4 and 3460/ND1 mutations induced resistance to rotenone and the 3460/ND1 mutation also provoked a marked decrease in the specific activity of complex I. Individuals heteroplasmic in platelets for either mutation showed normal biochemical features, indicating functional complementation of wild-type mtDNA. There was no correlation between the clinical status and mtDNA homo/heteroplasmy in platelets, but the biochemical features correlated with the mitochondrial genotype of platelets. In some cases, the degree of mtDNA heteroplasmy differed in platelets and leukocytes from the same individual with a prevalence of wild-type mtDNA in the platelets. These results imply that biochemical studies on mitochondrial diseases should always be integrated with mtDNA analysis of the same tissue investigated and also suggest that the mtDNA analysis on the leukocyte fraction, as usually performed in LHON, does not necessarily reflect the mutant genotype level of other tissues. The differential tissue heteroplasmy may be more relevant than previously thought in determining disease penetrance.

An Overview of Some Definitional Issues for Sports Injury Surveillance

Abstract: Injury surveillance is the ongoing collection of data describing the occurrence of, and factors associated with, injury. The success of any sports injury surveillance system and its wide scale applicability is dependent upon valid and reliable definitions of sports injury, injury severity and sports participation.

Response of a primary human fibroblast cell line to H2O2 : Senescence-like growth arrest or apoptosis?

Abstract: Hydrogen peroxide has been shown to induce either apoptosis or features of senescence in different cultured cell lines. We now show that both processes can be induced in the same culture of primary human diploid fibroblasts and that the outcome of apoptosis or the senescence-like phenotype is determined by the H2O2 concentrations. At 50 and 100 microM, H2O2 predominantly induced the senescence-like state, characterized by a reduced rate of proliferation, an increased number of cells in G0-G1, typically enlarged and flattened morphology, and increased CIP1 and fibronectin expression. At 300 and 400 microM, H2O2 mainly triggered apoptosis. At the intermediate 200 microM H2O2, features of both senescence and apoptosis were observed in the same culture. Thus, the higher the H2O2 concentration, the higher the proportion of cells undergoing apoptosis, suggesting a key role of the level of damage in the choice of a cell population to enter apoptosis and/or the senescence-like state. Before the induction of one or the other process, cells entered a transient "shock state" characterized by a typical morphological change, cell cycle arrest in G0-G1, and the induction of CIP1 and BCL-2.

Behavioral and Emotional Disturbance in Individuals With Williams Syndrome

Abstract: Behavioral and emotional disturbance was assessed in 70 children and adolescents with Williams syndrome. They were compared with an epidemiological control population, which was statistically controlled for age, gender, and level of mental retardation. Those with Williams syndrome were more likely to be diagnosed as suffering psychiatric disorder. The disorder was characterized by anxiety, hyperactivity, preoccupations, and inappropriate interpersonal relating. Significantly increased rates of other individual symptoms were also found, including sleep disturbance and hyperacusis. These results, considered with earlier findings, suggest that there is a valid behavior phenotype of Williams syndrome. This is frequently associated with sufficient impairment to consider inclusion of the behavior phenotype in future official taxonomies of mental disorders.

A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer.

Abstract: The ETS family of genes are implicated in cancers such as Ewings sarcoma, acute myeloid leukemia and chronic myelomonocytic leukemia. Further, they have important functions in embryonic development. Hence, identification and characterization of members of this family are important. We identify a novel ETS family member, ELF3, and report its human and murine cDNA sequences. The mouse cDNA has an alternatively spliced transcript with an extra 60 bp inserted. Hence we present the organization of the murine Elf3 gene together with its exon/intron structure. This gene consists of 9 exons and 8 introns spanning 4.8 kb. ELF3 binds and transactivates ETS sequences and interestingly also shows the ability to bind a GGAT-like purine core, a preferential ETS1/ETS2 type binding site. The expression of ELF3, unlike most other ETS family members, is absent in hematopoietic cells and hematopoietic organs in humans and mice. Intriguingly, the gene is specifically expressed in cell lines of epithelial origin and in organs such as lung, stomach, intestine, kidney that have specialized epithelial cells. We localize the human gene to 1q32.2, a region that is amplified in epithelial tumors of the breast, lung and prostate. Finally, we show that ELF3 expression is increased in a lung carcinoma and adenocarcinoma, as compared to normal tissue. ELF3 is also expressed in cell lines derived from lung cancers. These results suggest that this novel ETS gene may be involved in lung tumorigenesis.

Changes in the mechanical properties of human and amphibian muscle after eccentric exercise

Abstract: Following a series of eccentric contractions, that is stretching of the muscle while generating active tension, the length-tension relationship of isolated amphibian muscle has been shown to shift towards longer muscle lengths (Katz 1939; Wood et al. 1993). Here we report observations of electrically stimulated ankle extensor muscles of nine human subjects, demonstrating a similar shift in optimum angle for torque generation [3.9 (1.5)°] following exercise on an inclined treadmill that involved eccentric contractions in one leg. (All values are means with the SEMs in parentheses.) The shift in the unexercised, control leg was significantly less [mean 0.4 (0.7)°P < 0.05]. Correlated with this shift was a drop in torque [25.1 (5.6)% for the experimental leg; 1.6 (0.7)% for the control leg, P < 0.002]. Optimum angles returned to pre-exercise values by 2 days post-exercise, while torque took a week to recover. A similar shift in optimum length [12 (1.3)% of rest length] was obtained for five toad (Bufo marinus) sartorius muscles subjected to 25 eccentric contractions. Isometrically contracted control muscles showed a smaller shift [3.5 (1.6)%, n = 5]. Accompanying the shift was a drop in tension of 46 (3)% after the eccentric contractions [control isometric, 23 (6)%, P < 0.0001]. By 5 h after the eccentric contractions the shift had returned to control values, while tension had not recovered. When viewed with an electron microscope, sartorius muscles fixed immediately after the eccentric contractions exhibited many small, and a few larger, regions of myofilament disruption. In muscles fixed 5 h after the contractions, no small regions of disruption were visible, and the number of large regions was no greater than in those muscles fixed immediately after the eccentric contractions. These disruptions are interpreted as the cause of the shift in length-tension relationship.

Signcryption and Its Applications in Efficient Public Key Solutions

Abstract: Signcryption is a new paradigm in public key cryptography that simultaneously fulfills both the functions of digital signature and public key encryption in a logically single step, and with a cost significantly lower than that required by the traditional “signature followed by encryption” approach. This paper summarizes currently known construction methods for signcryption, carries out a comprehensive comparison between signcryption and “signature followed by encryption”, and suggests a number of applications of signcryption in the search of efficient security solutions based on public key cryptography.

ETS1, NFkappaB and AP1 synergistically transactivate the human GM-CSF promoter.

Abstract: Activation of helper T cells results in coordinate expression of a number of cytokines involved in differentiation, proliferation and activation of the haematopoietic system. Granulocyte-macrophage colony stimulating factor (GM – CSF) is one such cytokine, whose increased expression results mostly from increases in transcription. Cis-acting elements with NFκB, AP1 and ETS-like binding motifs have been identified in the promoter region of the GM – CSF gene, and are important or essential for transcriptional activity following T cell activation. ETS1 is a transcription factor of the ETS family that is expressed in T cells. We have previously shown that ETS1 can transactivate GM – CSF in Jurkat T cells, but only after the cells have been stimulated by treatment with PMA and ionomycin, agents that mimic T cell activation. Thus we proposed that ETS1, which is expressed constitutively in Jurkat cells, may act in concert with PMA/ionomycin inducible factors. Here we show that ETS1 can transactivate a GM – CSF reporter construct in unstimulated Jurkat cells, providing that either NFκB or AP1 transcription factors are supplied by co-transfection. We confirm that binding of endogenous NFκB and AP1 is induced following PMA/ionomycin treatment of T cells. Transactivation by ETS1, NFκB and AP1 is synergistic, and mutation of the individual binding sites reveals that the transcriptional activities of these factors are inter-dependent. Our results suggest that constitutive ETS1, and inducible NFκB and AP1, cooperate as part of a higher order transcriptional complex in activated T cells.