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Institution

Monash University

EducationMelbourne, Victoria, Australia
About: Monash University is a education organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 35920 authors who have published 100681 publications receiving 3027002 citations.


Papers
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Book
07 Dec 2011
TL;DR: A short course on well-founded interpretations of facies in modern and ancient successions was held at Monash University between 1981 and 1982 as mentioned in this paper, with the goal of providing geologists with a sound basis for making their own University to take up a Monash Postdoctoral Fellowship.
Abstract: from volcanological and sedimentological perspec The idea for this book carne into being between 1981 and 1982 when J. V. W. came to Monash tives. One of our aims in the book is to provide geologists with a sound basis for making their own University to take up a Monash Postdoctoral Fellowship. During this period a short course on well founded interpretations. For that reason we facies analysis in modern and ancient successions cover not only concepts about processes, and the was put together, integrating J. V. W. 's extensive nature of the products, but also methods and volcanological experience in numerous modern approaches that may be useful in analysing both modern and ancient successions. Most importantly, volcanic terrains with R. A. F. C. 's extensive sedi mentological and volcanological experience in we treat the diversity of products in volcanic older volcanic and associated sedimentary succes terrains as facies, and we use the method of facies sions in the Palaeozoic and Precambrian of analysis and interpretation as a means of construct Australia. The enthusiastic response from the ing facies models for different volcanic settings. participants to the first short course, taught in May These models will, we hope, be useful as norms 1982, and to subsequent annual re-runs, encour for comparison for workers in ancient terrains. aged us to develop the short course notes into this The only publication which overlaps with this one book."

392 citations

Journal ArticleDOI
TL;DR: It is shown that in mice deficient for CCR7 or its ligands mature single-positive thymocytes are arrested in the cortex and do not accumulate in the medulla, indicating that CCR 7 signals are essential for the migration of positively selectedThymocytes from the cortex to the medullary region of the thymus.
Abstract: Upon TCR-mediated positive selection, developing thymocytes relocate within the thymus from the cortex to the medulla for further differentiation and selection. However, it is unknown how this cortex-medulla migration of thymocytes is controlled and how it controls T cell development. Here we show that in mice deficient for CCR7 or its ligands mature single-positive thymocytes are arrested in the cortex and do not accumulate in the medulla. These mutant mice are defective in forming the medullary region of the thymus. Thymic export of T cells in these mice is compromised during the neonatal period but not in adulthood. Thymocytes in these mice show no defects in maturation, survival, and negative selection to ubiquitous antigens. TCR engagement of immature cortical thymocytes elevates the cell surface expression of CCR7. These results indicate that CCR7 signals are essential for the migration of positively selected thymocytes from the cortex to the medulla. CCR7-dependent cortex-medulla migration of thymocytes plays a crucial role in medulla formation and neonatal T cell export but is not essential for maturation, survival, negative selection, and adult export of thymocytes.

392 citations

Journal ArticleDOI
TL;DR: In this article, a systematic review of the psychological safety literature is presented, highlighting the need to advance our understanding of psychological safety through the integration of key theoretical perspectives to explain how psychological safety develops and influences work outcomes at different levels of analysis.

392 citations

Journal ArticleDOI
TL;DR: In this paper, a model of low-mass AGB stars with metallicity ranging between Z = 0.0138 (the solar one) and Z= 0.0001, with a full nuclear network coupled to the stellar evolution code and a mass loss-period-luminosity relation is presented.
Abstract: The envelope of thermally pulsing asymptotic giant branch (TP-AGB) stars undergoing periodic third dredge-up (TDU) episodes is enriched in both light and heavy elements, the ashes of a complex internal nucleosynthesis involving p, α, and n captures over hundreds of stable and unstable isotopes. In this paper, new models of low-mass AGB stars (2 M ☉), with metallicity ranging between Z = 0.0138 (the solar one) and Z = 0.0001, are presented. Main features are (1) a full nuclear network (from H to Bi) coupled to the stellar evolution code, (2) a mass loss-period-luminosity relation, based on available data for long-period variables, and (3) molecular and atomic opacities for C- and/or N-enhanced mixtures, appropriate for the chemical modifications of the envelope caused by the TDU. For each model, a detailed description of the physical and chemical evolutions is presented; moreover, we present a uniform set of yields, comprehensive of all chemical species (from hydrogen to bismuth). The main nucleosynthesis site is the thin 13C pocket, which forms in the core-envelope transition region after each TDU episode. The formation of this 13C pocket is the principal by-product of the introduction of a new algorithm, which shapes the velocity profile of convective elements at the inner border of the convective envelope: both the physical grounds and the calibration of the algorithm are discussed in detail. We find that the pockets shrink (in mass) as the star climbs the AGB, so that the first pockets, the largest ones, leave the major imprint on the overall nucleosynthesis. Neutrons are released by the 13C(α, n)16O reaction during the interpulse phase in radiative conditions, when temperatures within the pockets attain T ~ 1.0 × 108 K, with typical densities of (106-107) neutrons cm–3. Exceptions are found, as in the case of the first pocket of the metal-rich models (Z = 0.0138, Z = 0.006 and Z = 0.003), where the 13C is only partially burned during the interpulse: the surviving part is ingested in the convective zone generated by the subsequent thermal pulse (TP) and then burned at T ~ 1.5 × 108 K, thus producing larger neutron densities (up to 1011 neutrons cm–3). An additional neutron exposure, caused by the 22Ne(α, n)25Mg during the TPs, is marginally activated at large Z, but becomes an important nucleosynthesis source at low Z, when most of the 22Ne is primary. The final surface compositions of the various models reflect the differences in the initial iron-seed content and in the physical structure of AGB stars belonging to different stellar populations. Thus, at large metallicities the nucleosynthesis of light s-elements (Sr, Y, Zr) is favored, whilst, decreasing the iron content, the overproduction of heavy s-elements (Ba, La, Ce, Nd, Sm) and lead becomes progressively more important. At low metallicities (Z = 0.0001) the main product is lead. The agreement with the observed [hs/ls] index observed in intrinsic C stars at different [Fe/H] is generally good. For the solar metallicity model, we found an interesting overproduction of some radioactive isotopes, like 60Fe, as a consequence of the anomalous first 13C pocket. Finally, light elements (C, F, Ne, and Na) are enhanced at any metallicity.

392 citations

Journal ArticleDOI
06 Oct 2016-Nature
TL;DR: It is shown that 25 subunits are strictly required for assembly of a functional complex and 1 subunit is essential for cell viability, and coupling gene-editing technology with proteomics represents a powerful tool for dissecting large multi-subunit complexes and enables the study of complex dysfunction at a cellular level.
Abstract: Complex I (NADH:ubiquinone oxidoreductase) is the first enzyme of the mitochondrial respiratory chain and is composed of 45 subunits in humans, making it one of the largest known multi-subunit membrane protein complexes. Complex I exists in supercomplex forms with respiratory chain complexes III and IV, which are together required for the generation of a transmembrane proton gradient used for the synthesis of ATP. Complex I is also a major source of damaging reactive oxygen species and its dysfunction is associated with mitochondrial disease, Parkinson's disease and ageing. Bacterial and human complex I share 14 core subunits that are essential for enzymatic function; however, the role and necessity of the remaining 31 human accessory subunits is unclear. The incorporation of accessory subunits into the complex increases the cellular energetic cost and has necessitated the involvement of numerous assembly factors for complex I biogenesis. Here we use gene editing to generate human knockout cell lines for each accessory subunit. We show that 25 subunits are strictly required for assembly of a functional complex and 1 subunit is essential for cell viability. Quantitative proteomic analysis of cell lines revealed that loss of each subunit affects the stability of other subunits residing in the same structural module. Analysis of proteomic changes after the loss of specific modules revealed that ATP5SL and DMAC1 are required for assembly of the distal portion of the complex I membrane arm. Our results demonstrate the broad importance of accessory subunits in the structure and function of human complex I. Coupling gene-editing technology with proteomics represents a powerful tool for dissecting large multi-subunit complexes and enables the study of complex dysfunction at a cellular level.

392 citations


Authors

Showing all 36568 results

NameH-indexPapersCitations
Bert Vogelstein247757332094
Kenneth W. Kinzler215640243944
David J. Hunter2131836207050
David R. Williams1782034138789
Yang Yang1712644153049
Lei Jiang1702244135205
Dongyuan Zhao160872106451
Christopher J. O'Donnell159869126278
Leif Groop158919136056
Mark E. Cooper1581463124887
Theo Vos156502186409
Mark J. Smyth15371388783
Rinaldo Bellomo1471714120052
Detlef Weigel14251684670
Geoffrey Burnstock141148899525
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023250
20221,020
20219,402
20208,419
20197,409
20186,437