Monash University

About: Monash University is a education organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 35920 authors who have published 100681 publications receiving 3027002 citations.

Sex Differences and Statistical Stereotyping in Attitudes Toward Financial Risk

Abstract: Subjects in a laboratory experiment completed the Zuckerman Sensation-Seeking Scale (SSS) then chose among five alternative gambles with substantial financial stakes. The gambles differed in expected return and variance. Gambles were presented in one of two different frames in a between-subjects design. In one, subjects were paid a fixed sum for completing the survey and that sum was then at risk in the subsequent gamble choices. In the other, all payoff amounts for the gambles were non-negative. Subjects were paid according to their choices and the outcomes of the gambles. We tested for sex differences in this choice task and found women to be consistently more risk averse, on average, than men. We observed no difference across frames. Subjects were then asked to guess the gamble choices of each of the other participants and were rewarded for each correct answer. Subjects of both sexes did substantially better than chance in guessing the particular choices of individuals of both sexes, but both men and women overestimated the risk aversion of others, especially that of women, and most strongly of all with respect to men's predictions of women's choices. Possible real-world implications of biased assumptions about women's risk attitudes are discussed.

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

Abstract: Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). Impaired bioavailability and/or responsiveness to endogenous NO has been implicated in the pathogenesis of cardiovascular and other diseases. Current therapies that involve the use of organic nitrates and other NO donors have limitations, including non-specific interactions of NO with various biomolecules, lack of response and the development of tolerance following prolonged administration. Compounds that activate sGC in an NO-independent manner might therefore provide considerable therapeutic advantages. Here we review the discovery, biochemistry, pharmacology and clinical potential of haem-dependent sGC stimulators (including YC-1, BAY 41-2272, BAY 41-8543, CFM-1571 and A-350619) and haem-independent sGC activators (including BAY 58-2667 and HMR-1766).