Institution
Mordovian State University
Education•Saransk, Russia•
About: Mordovian State University is a education organization based out in Saransk, Russia. It is known for research contribution in the topics: Magnetic field & Electron. The organization has 1806 authors who have published 1610 publications receiving 7195 citations. The organization is also known as: Ogarev Mordovia State University & Ogarev Mordovia State University,.
Topics: Magnetic field, Electron, Computer science, Heptane, Resonance
Papers published on a yearly basis
Papers
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TL;DR: In aged tissues, enhanced mitochondria-mediated apoptosis contributes to an increase in the percentage of apoptotic cells and implementation of strategies such as caloric restriction and regular physical training may delay mitochondrial aging and attenuate the age-related phenotype in humans.
Abstract: Age-related changes in mitochondria are associated with decline in mitochondrial function. With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to accumulation of mutations and oxidative damage induced by reactive oxygen species (ROS). In aged subjects, mitochondria are characterized by impaired function such as lowered oxidative capacity, reduced oxidative phosphorylation, decreased ATP production, significant increase in ROS generation, and diminished antioxidant defense. Mitochondrial biogenesis declines with age due to alterations in mitochondrial dynamics and inhibition of mitophagy, an autophagy process that removes dysfunctional mitochondria. Age-dependent abnormalities in mitochondrial quality control further weaken and impair mitochondrial function. In aged tissues, enhanced mitochondria-mediated apoptosis contributes to an increase in the percentage of apoptotic cells. However, implementation of strategies such as caloric restriction and regular physical training may delay mitochondrial aging and attenuate the age-related phenotype in humans.
305 citations
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TL;DR: In this article, a self-contained presentation of the theory of self-adjoint extensions using the technique of boundary triples is given, and a description of the spectra of selfadjoint extension in terms of the corresponding Krein maps (Weyl functions) is given.
Abstract: We give a self-contained presentation of the theory of self-adjoint extensions using the technique of boundary triples. A description of the spectra of self-adjoint extensions in terms of the corresponding Krein maps (Weyl functions) is given. Applications include quantum graphs, point interactions, hybrid spaces and singular perturbations.
251 citations
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TL;DR: ROS is introduced and their relationship with abiotic stress-caused consequences in crop plants is highlighted, and the various physiological/biochemical aspects of oxidative damage to lipids and proteins in stressed crop plants are examined.
Abstract: Stress factors provoke enhanced production of reactive oxygen species (ROS) in plants. ROS that escape antioxidant-mediated scavenging/detoxification react with biomolecules such as cellular lipids and proteins and cause irreversible damage to the structure of these molecules, initiate their oxidation, and subsequently inactivate key cellular functions. The lipid- and protein-oxidation products are considered as the significant oxidative stress biomarkers in stressed plants. Also, there exists an abundance of information on the abiotic stress-mediated elevations in the generation of ROS, and the modulation of lipid and protein oxidation in abiotic stressed plants. However, the available literature reflects a wide information gap on the mechanisms underlying lipid- and protein-oxidation processes, major techniques for the determination of lipid- and protein-oxidation products, and on critical cross-talks among these aspects. Based on recent reports, this article (a) introduces ROS and highlights their relationship with abiotic stress-caused consequences in crop plants, (b) examines critically the various physiological/biochemical aspects of oxidative damage to lipids (membrane lipids) and proteins in stressed crop plants, (c) summarizes the principles of current technologies used to evaluate the extent of lipid and protein oxidation, (d) synthesizes major outcomes of studies on lipid and protein oxidation in plants under abiotic stress, and finally, (e) considers a brief cross-talk on the ROS-accrued lipid and protein oxidation, pointing to the aspects unexplored so far.
229 citations
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TL;DR: This paper aims to introduce oxidative stress-causative factors and highlights their relationship with abiotic stresses in plants, and to overview structure, occurrence, and significance of CAT and APX in plants.
Abstract: Plants have to counteract unavoidable stress-caused anomalies such as oxidative stress to sustain their lives and serve heterotrophic organisms including humans. Among major enzymatic antioxidants, catalase (CAT; EC 1.11.1.6) and ascorbate peroxidase (APX; EC 1.11.1.11) are representative heme enzymes meant for metabolizing stress-provoked reactive oxygen species (ROS; such as H2O2) and controlling their potential impacts on cellular metabolism and functions. CAT mainly occurs in peroxisomes and catalyzes the dismutation reaction without requiring any reductant; whereas, APX has a higher affinity for H2O2 and utilizes ascorbate (AsA) as specific electron donor for the reduction of H2O2 into H2O in organelles including chloroplasts, cytosol, mitochondria, and peroxisomes. Literature is extensive on the glutathione-associated H2O2-metabolizing systems in plants. However, discussion is meager or scattered in the literature available on the biochemical and genomic characterization as well as techniques for the assays of CAT and APX and their modulation in plants under abiotic stresses. This paper aims (a) to introduce oxidative stress-causative factors and highlights their relationship with abiotic stresses in plants; (b) to overview structure, occurrence, and significance of CAT and APX in plants;
201 citations
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TL;DR: Interferon-regulatory factors play a key role in hematopoietic development of monocytes, their differentiation to macrophages, and regulating macrophage maturation, phenotypic polarization, phenotypesic switch, and function.
194 citations
Authors
Showing all 1845 results
Name | H-index | Papers | Citations |
---|---|---|---|
Pavel P. Fedorov | 34 | 384 | 5004 |
Konstantin Pankrashkin | 23 | 121 | 2087 |
Sergei V. Firstov | 22 | 119 | 1677 |
Georgy V. Maksimov | 19 | 170 | 1458 |
Vl.A. Margulis | 15 | 81 | 778 |
Sergey N. Ushakov | 15 | 66 | 796 |
Igor Lobanov | 15 | 49 | 685 |
V. A. Geyler | 14 | 45 | 579 |
Victor V. Revin | 14 | 76 | 969 |
Polina A. Ryabochkina | 13 | 112 | 623 |
E.A. Gaiduk | 13 | 31 | 388 |
Vladimir Erofeev | 13 | 65 | 452 |
A. N. Kost | 12 | 195 | 505 |
A. S. Lukatkin | 12 | 36 | 800 |
Vladimir V. Matveev | 11 | 57 | 445 |