Moscow Institute of Physics and Technology

About: Moscow Institute of Physics and Technology is a education organization based out in Dolgoprudnyy, Russia. It is known for research contribution in the topics: Laser & Large Hadron Collider. The organization has 8594 authors who have published 16968 publications receiving 246551 citations. The organization is also known as: MIPT & Moscow Institute of Physics and Technology (State University).

A role for G-CSF and GM-CSF in nonmyeloid cancers

Abstract: Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) modulate progression of certain solid tumors. The G-CSF- or GM-CSF-secreting cancers, albeit not very common are, however, among the most rapidly advancing ones due to a cytokine-mediated immune suppression and angiogenesis. Similarly, de novo angiogenesis and vasculogenesis may complicate adjuvant use of recombinant G-CSF or GM-CSF thus possibly contributing to a cancer relapse. Rapid diagnostic tools to differentiate G-CSF- or GM-CSF-secreting cancers are not well developed therefore hindering efforts to individualize treatments for these patients. Given an increasing utilization of adjuvant G-/GM-CSF in cancer therapy, we aimed to summarize recent studies exploring their roles in pathophysiology of solid tumors and to provide insights into some complexities of their therapeutic applications.

Planned Products of the Mars Structure Service for the InSight Mission to Mars

Abstract: The InSight lander will deliver geophysical instruments to Mars in 2018, including seismometers installed directly on the surface (Seismic Experiment for Interior Structure, SEIS). Routine operations will be split into two services, the Mars Structure Service (MSS) and Marsquake Service (MQS), which will be responsible, respectively, for defining the structure models and seismicity catalogs from the mission. The MSS will deliver a series of products before the landing, during the operations, and finally to the Planetary Data System (PDS) archive. Prior to the mission, we assembled a suite of a priori models of Mars, based on estimates of bulk composition and thermal profiles. Initial models during the mission will rely on modeling surface waves and impact-generated body waves independent of prior knowledge of structure. Later modeling will include simultaneous inversion of seismic observations for source and structural parameters. We use Bayesian inversion techniques to obtain robust probability distribution functions of interior structure parameters. Shallow structure will be characterized using the hammering of the heatflow probe mole, as well as measurements of surface wave ellipticity. Crustal scale structure will be constrained by measurements of receiver function and broadband Rayleigh wave ellipticity measurements. Core interacting body wave phases should be observable above modeled martian noise levels, allowing us to constrain deep structure. Normal modes of Mars should also be observable and can be used to estimate the globally averaged 1D structure, while combination with results from the InSight radio science mission and orbital observations will allow for constraint of deeper structure.

Measurement of the integrated luminosities of the data taken by BESIII at √s = 3.650 and 3.773 GeV

Abstract: Data sets were collected with the BESIII detector at the BEPCII collider at the center-of-mass energy of √s = 3.650 GeV during May 2009 and at √s = 3.773 GeV from January 2010 to May 2011. By analyzing the large angle Bhabha scattering events, the integrated luminosities of the two data sets are measured to be (44.49±0.02±0.44) pb−1 and (2916.94±0.18±29.17) pb−1, respectively, where the first error is statistical and the second error is systematic.

Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charged leptons in proton-proton collisions at √s=13 TeV with the ATLAS detector

Abstract: A search for electroweak production of supersymmetric particles is performed in two-lepton and three-lepton final states using recursive jigsaw reconstruction, a technique that assigns reconstructed objects to the most probable hemispheres of the decay trees, allowing one to construct tailored kinematic variables to separate the signal and background. The search uses data collected in 2015 and 2016 by the ATLAS experiment in s=13 TeV proton-proton collisions at the CERN Large Hadron Collider corresponding to an integrated luminosity of 36.1 fb-1. Chargino-neutralino pair production, with decays via W/Z bosons, is studied in final states involving leptons and jets and missing transverse momentum for scenarios with large and intermediate mass splittings between the parent particle and lightest supersymmetric particle, as well as for the scenario where this mass splitting is close to the mass of the Z boson. The latter case is challenging since the vector bosons are produced with kinematic properties that are similar to those in Standard Model processes. Results are found to be compatible with the Standard Model expectations in the signal regions targeting large and intermediate mass splittings, and chargino-neutralino masses up to 600 GeV are excluded at 95% confidence level for a massless lightest supersymmetric particle. Excesses of data above the expected background are found in the signal regions targeting low mass splittings, and the largest local excess amounts to 3.0 standard deviations. © 2018 CERN, for the ATLAS Collaboration. Published by the American Physical Society.

Search for production of four top quarks in final states with same-sign or multiple leptons in proton-proton collisions at √{s }=13 TeV

Abstract: The standard model (SM) production of four top quarks ($\text {t} {}{\overline{\text {t}}} \text {t} {}{\overline{\text {t}}} $) in proton–proton collisions is studied by the CMS Collaboration. The data sample, collected during the 2016–2018 data taking of the LHC, corresponds to an integrated luminosity of 137$\,\text {fb}^{-1}$ at a center-of-mass energy of 13$\,\text {TeV}$. The events are required to contain two same-sign charged leptons (electrons or muons) or at least three leptons, and jets. The observed and expected significances for the $\text {t} {}{\overline{\text {t}}} \text {t} {}{\overline{\text {t}}} $ signal are respectively 2.6 and 2.7 standard deviations, and the $\text {t} {}{\overline{\text {t}}} \text {t} {}{\overline{\text {t}}} $ cross section is measured to be $12.6^{+5.8}_{-5.2}\,\text {fb} $. The results are used to constrain the Yukawa coupling of the top quark to the Higgs boson, $y_{\text {t}}$, yielding a limit of $|y_{\text {t}}/y_{\text {t}}^{\mathrm {SM}} | < 1.7$ at $95\%$ confidence level, where $y_{\text {t}}^{\mathrm {SM}}$ is the SM value of $y_{\text {t}}$. They are also used to constrain the oblique parameter of the Higgs boson in an effective field theory framework, $\hat{H}<0.12$. Limits are set on the production of a heavy scalar or pseudoscalar boson in Type-II two-Higgs-doublet and simplified dark matter models, with exclusion limits reaching 350–470$\,\text {GeV}$ and 350–550$\,\text {GeV}$ for scalar and pseudoscalar bosons, respectively. Upper bounds are also set on couplings of the top quark to new light particles.