Showing papers by "Moscow State University published in 2010"
TL;DR: This review describes the current experimental tools to study endocytosis of nanomedicines and provides specific examples from recent literature and the authors' own work on endocyTosis of Nanomedicine.
1,819 citations
University of Glasgow1, University of Salerno2, Max Planck Society3, University of Southampton4, University of Paris-Sud5, Paris Diderot University6, VU University Amsterdam7, University of Nice Sophia Antipolis8, Washington State University9, University of Warsaw10, University of Birmingham11, Cardiff University12, University of Rome Tor Vergata13, Moscow State University14, California Institute of Technology15, fondazione bruno kessler16, Centre national de la recherche scientifique17, University of Cambridge18, University of Tübingen19, University of Urbino20, University of Vienna21, University of Minnesota22, University of Jena23, Albert Einstein Institution24, Northwestern University25, University of Savoy26, Pennsylvania State University27, University of Pisa28, Sapienza University of Rome29, University of Florence30
TL;DR: The third-generation ground-based observatory Einstein Telescope (ET) project as discussed by the authors is currently in its design study phase, and it can be seen as the first step in this direction.
Abstract: Advanced gravitational wave interferometers, currently under realization, will soon permit the detection of gravitational waves from astronomical sources. To open the era of precision gravitational wave astronomy, a further substantial improvement in sensitivity is required. The future space-based Laser Interferometer Space Antenna and the third-generation ground-based observatory Einstein Telescope (ET) promise to achieve the required sensitivity improvements in frequency ranges. The vastly improved sensitivity of the third generation of gravitational wave observatories could permit detailed measurements of the sources' physical parameters and could complement, in a multi-messenger approach, the observation of signals emitted by cosmological sources obtained through other kinds of telescopes. This paper describes the progress of the ET project which is currently in its design study phase.
1,497 citations
TL;DR: In this paper, Kalogera et al. presented an up-to-date summary of the rates for all types of compact binary coalescence sources detectable by the initial and advanced versions of the ground-based gravitational-wave detectors LIGO and Virgo.
Abstract: We present an up-to-date, comprehensive summary of the rates for all types of compact binary coalescence sources detectable by the initial and advanced versions of the ground-based gravitational-wave detectors LIGO and Virgo. Astrophysical estimates for compact-binary coalescence rates depend on a number of assumptions and unknown model parameters and are still uncertain. The most confident among these estimates are the rate predictions for coalescing binary neutron stars which are based on extrapolations from observed binary pulsars in our galaxy. These yield a likely coalescence rate of 100 Myr−1 per Milky Way Equivalent Galaxy (MWEG), although the rate could plausibly range from 1 Myr−1 MWEG−1 to 1000 Myr−1 MWEG−1 (Kalogera et al 2004 Astrophys. J. 601 L179; Kalogera et al 2004 Astrophys. J. 614 L137 (erratum)). We convert coalescence rates into detection rates based on data from the LIGO S5 and Virgo VSR2 science runs and projected sensitivities for our advanced detectors. Using the detector sensitivities derived from these data, we find a likely detection rate of 0.02 per year for Initial LIGO–Virgo interferometers, with a plausible range between 2 × 10−4 and 0.2 per year. The likely binary neutron–star detection rate for the Advanced LIGO–Virgo network increases to 40 events per year, with a range between 0.4 and 400 per year.
1,011 citations
Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2197 more•Institutions (149)
TL;DR: The pre-print version of the Published Article can be accessed from the link below - Copyright @ 2010 Springer Verlag as discussed by the authors, which can be viewed as a preprint of the published article.
Abstract: This is the pre-print version of the Published Article, which can be accessed from the link below - Copyright @ 2010 Springer Verlag
717 citations
TL;DR: In this paper, the first measurement of charged particle elliptic flow in Pb-Pb collisions at root s(NN) p = 2.76 TeV with the ALICE detector at the CERN Large Hadron Collider was performed in the central pseudorapidity region.
Abstract: We report the first measurement of charged particle elliptic flow in Pb-Pb collisions at root s(NN) p = 2.76 TeV with the ALICE detector at the CERN Large Hadron Collider. The measurement is performed in the central pseudorapidity region (vertical bar eta vertical bar < 0.8) and transverse momentum range 0.2 < p(t) < 5.0 GeV/c. The elliptic flow signal v(2), measured using the 4-particle correlation method, averaged over transverse momentum and pseudorapidity is 0.087 +/- 0.002(stat) +/- 0.003(syst) in the 40%-50% centrality class. The differential elliptic flow v(2)(p(t)) reaches a maximum of 0.2 near p(t) = 3 GeV/c. Compared to RHIC Au-Au collisions at root s(NN) = 200 GeV, the elliptic flow increases by about 30%. Some hydrodynamic model predictions which include viscous corrections are in agreement with the observed increase.
652 citations
TL;DR: In this article, the authors used the ATLAS detector to detect dijet asymmetry in the collisions of lead ions at the Large Hadron Collider and found that the transverse energies of dijets in opposite hemispheres become systematically more unbalanced with increasing event centrality, leading to a large number of events which contain highly asymmetric di jets.
Abstract: By using the ATLAS detector, observations have been made of a centrality-dependent dijet asymmetry in the collisions of lead ions at the Large Hadron Collider. In a sample of lead-lead events with a per-nucleon center of mass energy of 2.76 TeV, selected with a minimum bias trigger, jets are reconstructed in fine-grained, longitudinally segmented electromagnetic and hadronic calorimeters. The transverse energies of dijets in opposite hemispheres are observed to become systematically more unbalanced with increasing event centrality leading to a large number of events which contain highly asymmetric dijets. This is the first observation of an enhancement of events with such large dijet asymmetries, not observed in proton-proton collisions, which may point to an interpretation in terms of strong jet energy loss in a hot, dense medium.
630 citations
TL;DR: In this article, a combination of the inclusive deep inelastic cross sections measured by the H1 and ZEUS Collaborations in neutral and charged current unpolarised e(+/-)p scattering at HERA during the period 1994-2000 is presented.
Abstract: A combination is presented of the inclusive deep inelastic cross sections measured by the H1 and ZEUS Collaborations in neutral and charged current unpolarised e(+/-)p scattering at HERA during the period 1994-2000. The data span six orders of magnitude in negative four-momentum-transfer squared, Q(2), and in Bjorken x. The combination method used takes the correlations of systematic uncertainties into account, resulting in an improved accuracy. The combined data are the sole input in a NLO QCD analysis which determines a new set of parton distributions, HERAPDF1.0, with small experimental uncertainties. This set includes an estimate of the model and parametrisation uncertainties of the fit result.
624 citations
University of Glasgow1, University of Oxford2, University of Texas Health Science Center at San Antonio3, Novartis4, Moscow State University5, University of North Carolina at Chapel Hill6, University College Cork7, Federal University of São Paulo8, National Taiwan University9, Centre Hospitalier Universitaire de Nantes10, The Chinese University of Hong Kong11, University of Leicester12, University of California, Berkeley13, University of Bern14, Tulane University15, Royal North Shore Hospital16, Medical University of Warsaw17, Harvard University18, Istanbul University19, University of Tromsø20, University of Washington21, Alfred Hospital22, University of Toronto23, University of Cape Town24, Cordoba University25, University of Illinois at Chicago26, Lahey Hospital & Medical Center27, University Medical Center Utrecht28, Umeå University29, Dresden University of Technology30, University of Liège31, Aarhus University32, Cardiovascular Institute of the South33, University of Copenhagen34, Semmelweis University35, University of Helsinki36, Duke University37
TL;DR: Among patients with impaired glucose tolerance and cardiovascular disease or risk factors, the use of valsartan for 5 years, along with lifestyle modification, led to a relative reduction of 14% in the incidence of diabetes but did not reduce the rate of cardiovascular events.
Abstract: BACKGROUND: It is not known whether drugs that block the renin-angiotensin system reduce the risk of diabetes and cardiovascular events in patients with impaired glucose tolerance. METHODS: In this double-blind, randomized clinical trial with a 2-by-2 factorial design, we assigned 9306 patients with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors to receive valsartan (up to 160 mg daily) or placebo (and nateglinide or placebo) in addition to lifestyle modification. We then followed the patients for a median of 5.0 years for the development of diabetes (6.5 years for vital status). We studied the effects of valsartan on the occurrence of three coprimary outcomes: the development of diabetes; an extended composite outcome of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure, arterial revascularization, or hospitalization for unstable angina; and a core composite outcome that excluded unstable angina and revascularization. RESULTS: The cumulative incidence of diabetes was 33.1% in the valsartan group, as compared with 36.8% in the placebo group (hazard ratio in the valsartan group, 0.86; 95% confidence interval [CI], 0.80 to 0.92; P<0.001). Valsartan, as compared with placebo, did not significantly reduce the incidence of either the extended cardiovascular outcome (14.5% vs. 14.8%; hazard ratio, 0.96; 95% CI, 0.86 to 1.07; P=0.43) or the core cardiovascular outcome (8.1% vs. 8.1%; hazard ratio, 0.99; 95% CI, 0.86 to 1.14; P=0.85). CONCLUSIONS: Among patients with impaired glucose tolerance and cardiovascular disease or risk factors, the use of valsartan for 5 years, along with lifestyle modification, led to a relative reduction of 14% in the incidence of diabetes but did not reduce the rate of cardiovascular events. (ClinicalTrials.gov number, NCT00097786.)
620 citations
TL;DR: The sphingolipid bases, D-erythro- and D-threo-sphingosines, are the target molecules that have been synthesized to demonstrate the efficiency of a new methodology to control both absolute and relative configurations in acyclic systems.
Abstract: The sphingolipid bases, D-erythro- and D-threo-sphingosines, are the target molecules that have been synthesized to demonstrate the efficiency of a new methodology to control both absolute and relative configurations in acyclic systems. Tubulysins are compounds of extraordinary potency, rapidly degrading the tubulin cytoskeleton, with tubulysin D being the most active tubulin-modifier known so far. Among other isonitriles, isocyanoacetate derivatives occupy an important place in the field of synthetic application and reaction diversity, which makes them strongly attractive objects for investigation. The unique multifunctional nature of isocyanoacetic acid derivatives opens up a range of exciting reactions, especially tandem/cascade processes for the synthesis of complex cyclic and macrocyclic systems. Multicomponent chemistry of isocyanoacetates is also a powerful instrument to access different classes of biochemically relevant compounds such as peptides, peptide molecules, and nitrogen heterocycles.
468 citations
Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2087 more•Institutions (132)
TL;DR: In this article, the authors measured the transverse momentum and pseudorapidity distributions in proton-proton collisions at root s = 7 TeV with the inner tracking system of the CMS detector at the LHC.
Abstract: Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at root s = 7 TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dN(ch)/d eta vertical bar(vertical bar eta vertical bar<0.5) = 5.78 +/- 0.01(stat) +/- 0.23(stat) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from root s = 0.9 to 7 TeV is [66.1 +/- 1.0(stat) +/- 4.2(syst)]%. The mean transverse momentum is measured to be 0.545 +/- 0.005(stat) +/- 0.015(syst) GeV/c. The results are compared with similar measurements at lower energies.
464 citations
University of Oxford1, University of Texas Health Science Center at San Antonio2, University of Leicester3, Duke University4, Novartis5, Moscow State University6, University of North Carolina at Chapel Hill7, University College Cork8, Federal University of São Paulo9, National Taiwan University10, The Chinese University of Hong Kong11, University of California, San Francisco12, Veterans Health Administration13, University of Bern14, University of California, San Diego15, Tulane University16, University of Sydney17, Medical University of Warsaw18, Harvard University19, Istanbul University20, University of Oslo21, University of Washington22, Monash University23, University of Eastern Finland24, University of Toronto25, University of Cape Town26, National University of Cordoba27, University of Illinois at Chicago28, Lahey Hospital & Medical Center29, Massachusetts Institute of Technology30, National and Kapodistrian University of Athens31, Utrecht University32, Umeå University33, Dresden University of Technology34, University of Liège35, Aarhus University36, University of Buenos Aires37, Masaryk University38, University of Copenhagen39, Semmelweis University40, Mario Negri Institute for Pharmacological Research41, University of Helsinki42
TL;DR: Among persons with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors, assignment to nateglinide for 5 years did not reduce the incidence of diabetes or the coprimary composite cardiovascular outcomes.
Abstract: After adjustment for multiple testing, nateglinide, as compared with placebo, did not significantly reduce the cumulative incidence of diabetes (36% and 34%, respectively; hazard ratio, 1.07; 95% confidence interval [CI], 1.00 to 1.15; P = 0.05), the core composite cardiovascular outcome (7.9% and 8.3%, respectively; hazard ratio, 0.94, 95% CI, 0.82 to 1.09; P = 0.43), or the extended composite cardiovascular outcome (14.2% and 15.2%, respectively; hazard ratio, 0.93, 95% CI, 0.83 to 1.03; P = 0.16). Nateglinide did, however, increase the risk of hypoglycemia. Conclusions Among persons with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors, assignment to nateglinide for 5 years did not reduce the incidence of diabetes or the coprimary composite cardiovascular outcomes. (ClinicalTrials.gov number, NCT00097786.)
TL;DR: The results of the International Permafrost Association's TSP project are presented in this article based on field measurements from Russia during the IPY years (2007-09) and collected historical data.
Abstract: The results of the International Permafrost Association’s International Polar Year Thermal State of Permafrost (TSP) project are presented based on field measurements from Russia during the IPY years (2007–09) and collected historical data. Most ground temperatures measured in existing and new boreholes show a substantial warming during the last 20 to 30 years. The magnitude of the warming varied with location, but was typically from 0.58 Ct o 28C at the depth of zero annual amplitude. Thawing of Little Ice Age permafrost is ongoing at many locations. There are some indications that the late Holocene permafrost has begun to thaw at some undisturbed locations in northeastern Europe and northwest Siberia. Thawing of permafrost is most noticeable within the discontinuous permafrost domain. However, permafrost in Russia is also starting to thaw at some limited locations in the continuous permafrost zone. As a result, a northward displacement of the boundary between continuous and discontinuous permafrost zones was observed. This data set will serve as a baseline against which to measure changes of near-surface permafrost temperatures and permafrost boundaries, to validate climate model scenarios, and for temperature reanalysis. Copyright # 2010 John Wiley & Sons, Ltd.
TL;DR: The first farmers from Central Europe reveal a genetic affinity to modern-day populations from the Near East and Anatolia, which suggests a significant demographic input from this area during the early Neolithic.
Abstract: In Europe, the Neolithic transition (8,000–4,000 B.C.) from hunting and gathering to agricultural communities was one of the most important demographic events since the initial peopling of Europe by anatomically modern humans in the Upper Paleolithic (40,000 B.C.). However, the nature and speed of this transition is a matter of continuing scientific debate in archaeology, anthropology, and human population genetics. To date, inferences about the genetic make up of past populations have mostly been drawn from studies of modern-day Eurasian populations, but increasingly ancient DNA studies offer a direct view of the genetic past. We genetically characterized a population of the earliest farming culture in Central Europe, the Linear Pottery Culture (LBK; 5,500–4,900 calibrated B.C.) and used comprehensive phylogeographic and population genetic analyses to locate its origins within the broader Eurasian region, and to trace potential dispersal routes into Europe. We cloned and sequenced the mitochondrial hypervariable segment I and designed two powerful SNP multiplex PCR systems to generate new mitochondrial and Y-chromosomal data from 21 individuals from a complete LBK graveyard at Derenburg Meerenstieg II in Germany. These results considerably extend the available genetic dataset for the LBK (n=42) and permit the first detailed genetic analysis of the earliest Neolithic culture in Central Europe (5,500–4,900 calibrated B.C.). We characterized the Neolithic mitochondrial DNA sequence diversity and geographical affinities of the early farmers using a large database of extant Western Eurasian populations (n=23,394) and a wide range of population genetic analyses including shared haplotype analyses, principal component analyses, multidimensional scaling, geographic mapping of genetic distances, and Bayesian Serial Simcoal analyses. The results reveal that the LBK population shared an affinity with the modern-day Near East and Anatolia, supporting a major genetic input from this area during the advent of farming in Europe. However, the LBK population also showed unique genetic features including a clearly distinct distribution of mitochondrial haplogroup frequencies, confirming that major demographic events continued to take place in Europe after the early Neolithic.
TL;DR: In this paper, a series of experiments using a 2D petrological-thermomechanical numerical model of oceanic subduction was conducted to investigate the dependence of tectono-metamorphic and magmatic regimes at an active plate margin on upper-mantle temperature, crustal radiogenic heat production, degree of lithospheric weakening and other parameters.
University of Glasgow1, University of Salerno2, Max Planck Society3, University of Southampton4, University of Paris-Sud5, VU University Amsterdam6, University of Nice Sophia Antipolis7, Washington State University8, University of Zielona Góra9, University of Birmingham10, Cardiff University11, University of Rome Tor Vergata12, Moscow State University13, California Institute of Technology14, fondazione bruno kessler15, Centre national de la recherche scientifique16, University of Cambridge17, University of Tübingen18, University of Urbino19, University of Vienna20, University of Minnesota21, University of Jena22, Northwestern University23, University of Savoy24, Pennsylvania State University25, University of Pisa26, Sapienza University of Rome27, Roma Tre University28, University of Florence29
TL;DR: The status of the project Einstein Telescope (ET), a design study of a third-generation gravitational wave observatory, is reported in this paper, where an overview of the possible science reaches and the technological progress needed to realize a third generation observatory are discussed.
Abstract: Large gravitational wave interferometric detectors, like Virgo and LIGO, demonstrated the capability to reach their design sensitivity, but to transform these machines into an effective observational instrument for gravitational wave astronomy a large improvement in sensitivity is required. Advanced detectors in the near future and third-generation observatories in more than one decade will open the possibility to perform gravitational wave astronomical observations from the Earth. An overview of the possible science reaches and the technological progress needed to realize a third-generation observatory are discussed in this paper. The status of the project Einstein Telescope (ET), a design study of a third-generation gravitational wave observatory, will be reported.
Max Planck Society1, University of Milan2, University of Massachusetts Amherst3, Princeton University4, PSL Research University5, Petersburg Nuclear Physics Institute6, Kurchatov Institute7, Moscow State University8, Joint Institute for Nuclear Research9, Technische Universität München10, Virginia Tech11, Jagiellonian University12
TL;DR: In this paper, the authors reported the measurement of elastic scattering from {sup 8}B solar neutrinos with 3 MeV energy threshold by the Borexino detector in Gran Sasso (Italy).
Abstract: We report the measurement of {nu}-e elastic scattering from {sup 8}B solar neutrinos with 3 MeV energy threshold by the Borexino detector in Gran Sasso (Italy). The rate of solar neutrino-induced electron scattering events above this energy in Borexino is 0.22{+-}0.04(stat){+-}0.01(syst) cpd/100 t, which corresponds to {Phi}{sub {sup 8}B}{sup ES}=2.4{+-}0.4{+-}0.1x10{sup 6} cm{sup -2} s{sup -1}, in good agreement with measurements from SNO and SuperKamiokaNDE. Assuming the {sup 8}B neutrino flux predicted by the high metallicity standard solar model, the average {sup 8}B {nu}{sub e} survival probability above 3 MeV is measured to be 0.29{+-}0.10. The survival probabilities for {sup 7}Be and {sup 8}B neutrinos as measured by Borexino differ by 1.9{sigma}. These results are consistent with the prediction of the MSW-LMA solution of a transition in the solar {nu}{sub e} survival probability P{sub ee} between the low-energy vacuum-driven and the high-energy matter-enhanced solar neutrino oscillation regimes.
TL;DR: The first measurement of the charged particle multiplicity density at midrapidity in Pb-Pb collisions at a center-of-mass energy per nucleon pair root s(NN) = 2.76 TeV is presented in this paper.
Abstract: The first measurement of the charged-particle multiplicity density at midrapidity in Pb-Pb collisions at a center-of-mass energy per nucleon pair root s(NN) = 2.76 TeV is presented. For an event sample corresponding to the most central 5% of the hadronic cross section, the pseudorapidity density of primary charged particles at midrapidity is 1584 +/- 4(stat) +/- 76(syst), which corresponds to 8.3 +/- 0.4(syst) per participating nucleon pair. This represents an increase of about a factor 1.9 relative to pp collisions at similar collision energies, and about a factor 2.2 to central Au-Au collisions at root s(NN) = 0.2 TeV. This measurement provides the first experimental constraint for models of nucleus-nucleus collisions at LHC energies.
TL;DR: The apatite supergroup includes minerals with a generic chemical formula IX M12 VII M23( IV TO4)3 X( Z ¼ 2), chemically they can be phosphates, arsenates, vanadates, silicates, and sulphates as mentioned in this paper.
Abstract: The apatite supergroup includes minerals with a generic chemical formula IX M12 VII M23( IV TO4)3 X( Z ¼ 2); chemically they can be phosphates, arsenates, vanadates, silicates, and sulphates. The maximum space group symmetry is P63/m, but several members of the supergroup have a lower symmetry due to cation ordering and deviations from the ideal topology, which may result in an increase of the number of the independent sites. The apatite supergroup can be formally divided into five groups, based on crystal-chemical arguments: apatite group, hedyphane group, belovite group, britholite group, and ellestadite group. The abundance of distinct ions which may be hosted at the key-sites (M ¼ Ca 2þ , Pb 2þ , Ba 2þ , Sr 2þ , Mn 2þ , Na þ , Ce 3þ , La 3þ ,Y 3þ , Bi 3þ ;T ¼ P 5þ , As 5þ ,V 5þ , Si 4þ ,S 6þ ,B 3þ ;X ¼ F � , (OH) � , Cl � ) result in a large number of compositions which may have the status of distinct mineral species. Naming of apatite supergroup minerals in the past has resulted in nomenclature inconsistencies and problems. Therefore, an ad hoc IMA-CNMNC Subcommittee was established with the aim of rationalizing the nomenclature within the apatite supergroup and making some order among existing and potentially new mineral species. In addition to general recommendations for the handling of chemical (EPMA) data and for the allocation of ions within the various sites, the main recommendations of this subcommittee are the following: 1. Nomenclature changes to existing minerals. The use of adjectival prefixes for anions is to be preferred instead of modified Levinson suffixes; accordingly, six minerals should be renamed as follows: apatite-(CaF) to fluorapatite, apatite-(CaOH) to hydroxylapatite, apatite-(CaCl) to chlorapatite, ellestadite-(F) to fluorellestadite, ellestadite-(OH) to hydroxylellestadite, phospho- hedyphane-(F) to fluorphosphohedyphane. For the apatite group species these changes return the names that have been used in thousands of scientific paper, treatises and museum catalogues over the last 150 years. The new mineral IMA 2008-009, approved without a name, is here named stronadelphite. Apatite-(SrOH) is renamed fluorstrophite. Deloneite-(Ce) is renamed deloneite. The new mineral IMA 2009-005 is approved with the name fluorbritholite-(Y).
Duke University1, Quintiles2, Clemson University3, University of Duisburg-Essen4, St. Vincent's Health System5, Khon Kaen University6, University of Birmingham7, University of Barcelona8, Favaloro University9, Moscow State University10, Royal Melbourne Hospital11, Alfred Hospital12, University of Gothenburg13
TL;DR: Early surgery for NVE is associated with an in-hospital mortality benefit compared with medical therapy alone and characteristics of patients who are most likely to benefit from early surgery are identified.
Abstract: Background—The impact of early surgery on mortality in patients with native valve endocarditis (NVE) is unresolved. This study sought to evaluate valve surgery compared with medical therapy for NVE and to identify characteristics of patients who are most likely to benefit from early surgery. Methods and Results—Using a prospective, multinational cohort of patients with definite NVE, the effect of early surgery on in-hospital mortality was assessed by propensity-based matching adjustment for survivor bias and by instrumental variable analysis. Patients were stratified by propensity quintile, paravalvular complications, valve perforation, systemic embolization, stroke, Staphylococcus aureus infection, and congestive heart failure. Of the 1552 patients with NVE, 720 (46%) underwent early surgery and 832 (54%) were treated with medical therapy. Compared with medical therapy, early surgery was associated with a significant reduction in mortality in the overall cohort (12.1% [87/720] versus 20.7% [172/832]) and after propensity-based matching and adjustment for survivor bias (absolute risk reduction [ARR] 5.9%, P0.001). With a combined instrument, the instrumental-variable–adjusted ARR in mortality associated with early surgery was 11.2% (P0.001). In subgroup analysis, surgery was found to confer a survival benefit compared with medical therapy among patients with a higher propensity for surgery (ARR 10.9% for quintiles 4 and 5, P0.002) and those with paravalvular complications (ARR 17.3%, P0.001), systemic embolization (ARR 12.9%, P0.002), S aureus NVE (ARR 20.1%, P0.001), and stroke (ARR 13%, P0.02) but not those with valve perforation or congestive heart failure. Conclusions—Early surgery for NVE is associated with an in-hospital mortality benefit compared with medical therapy alone. (Circulation. 2010;121:1005-1013.)
TL;DR: The results of the study demonstrated that the efficacy of brain delivery by nanoparticles not only is influenced by the coating surfactants but also by other formulation parameters such as core polymer, drug, and stabilizer.
13 Jun 2010
TL;DR: A new probabilistic framework for object detection which is related to the Hough transform is developed which bypasses the problem of multiple peak identification in Hough images and permits detection of multiple objects without invoking nonmaximum suppression heuristics.
Abstract: To detect multiple objects of interest, the methods based on Hough transform use non-maxima supression or mode seeking in order to locate and to distinguish peaks in Hough images. Such postprocessing requires tuning of extra parameters and is often fragile, especially when objects of interest tend to be closely located. In the paper, we develop a new probabilistic framework that is in many ways related to Hough transform, sharing its simplicity and wide applicability. At the same time, the framework bypasses the problem of multiple peaks identification in Hough images, and permits detection of multiple objects without invoking nonmaximum suppression heuristics. As a result, the experiments demonstrate a significant improvement in detection accuracy both for the classical task of straight line detection and for a more modern category-level (pedestrian) detection problem.
TL;DR: These observations suggest that these electronic properties capture the majority of ingredients necessary for the superconductivity in iron pnictides.
Abstract: We have studied the electronic structure of the nonmagnetic LiFeAs (${T}_{c}\ensuremath{\sim}18\text{ }\text{ }\mathrm{K}$) superconductor using angle-resolved photoemission spectroscopy. We find a notable absence of the Fermi surface nesting, strong renormalization of the conduction bands by a factor of 3, high density of states at the Fermi level caused by a van Hove singularity, and no evidence for either a static or a fluctuating order except superconductivity with in-plane isotropic energy gaps. Our observations suggest that these electronic properties capture the majority of ingredients necessary for the superconductivity in iron pnictides.
Book•
21 Jul 2010TL;DR: In this article, the main ideas and results of the Malliavin calculus are presented, a powerful method to study smoothness properties of the distributions of nonlinear functionals on infinite dimensional spaces with measures.
Abstract: This book provides the reader with the principal concepts and results related to differential properties of measures on infinite dimensional spaces. In the finite dimensional case such properties are described in terms of densities of measures with respect to Lebesgue measure. In the infinite dimensional case new phenomena arise. For the first time a detailed account is given of the theory of differentiable measures, initiated by S. V. Fomin in the 1960s; since then the method has found many various important applications. Differentiable properties are described for diverse concrete classes of measures arising in applications, for example, Gaussian, convex, stable, Gibbsian, and for distributions of random processes. Sobolev classes for measures on finite and infinite dimensional spaces are discussed in detail. Finally, we present the main ideas and results of the Malliavin calculus--a powerful method to study smoothness properties of the distributions of nonlinear functionals on infinite dimensional spaces with measures. The target readership includes mathematicians and physicists whose research is related to measures on infinite dimensional spaces, distributions of random processes, and differential equations in infinite dimensional spaces. The book includes an extensive bibliography on the subject. Table of Contents: Background material; Sobolev spaces on $\mathbb{R}^n$; Differentiable measures on linear spaces; Some classes of differentiable measures; Subspaces of differentiability of measures; Integration by parts and logarithmic derivatives; Logarithmic gradients; Sobolev classes on infinite dimensional spaces; The Malliavin calculus; Infinite dimensional transformations; Measures on manifolds; Applications; References; Subject index. (Surv/164)
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TL;DR: NIR spectroscopy was found to be effective for gasoline classification purposes, when compared with nuclear magnetic resonance (NMR)Spectroscopy or gas chromatography (GC), and KNN, SVM, and PNN techniques for classification were find to be among the most effective ones.
TL;DR: This Letter considers in this Letter the purely gluonic contribution which provides, in combination with the previous fermion corrections, the complete answer at three loops.
Abstract: We compute the three-loop corrections to the potential of two heavy quarks. In particular, we consider in this Letter the purely gluonic contribution which provides, in combination with our previous fermion corrections, the complete answer at three loops.
TL;DR: In this article, the electroproduction of charged $ \rho$¯¯ -mesons on the nucleon at intermediate energy is discussed for quasi-elastic kinematics. And the differential cross-sections for the reaction p(e, e¯¯ ′� ′¯¯ $ \ rho^{+}_{}$� )n at Qcffff 2 = 2, 3.5GeV^2 and at the invariant mass W = 3 and 4GeV are calculated on the basis of quasi-Elastic knockout mechanism with form factors.
Abstract: The electroproduction of charged $ \rho$
-mesons on the nucleon at intermediate energy is discussed for quasi-elastic kinematics. It is shown that at these kinematics both the longitudinal $ \sigma_{{L}}^{}$
and transverse $ \sigma_{{T}}^{}$
cross-sections are dominated by the $ \rho$
-meson t -pole contribution, and thus the corresponding dσL(T)/dt data can give a valuable information on the $ \rho$
-meson component of the nucleon cloud. The differential cross-sections for the reaction p(e, e
′
$ \rho^{+}_{}$
)n at Q
2 = 2 , 3.5GeV^2 and at the invariant mass W = 3 and 4GeV are calculated on the basis of quasi-elastic knockout mechanism with form factors. Questions about the gauge invariance of the electroproduction amplitude are considered and it is noted an important difference between photo- and electroproduction amplitudes.
TL;DR: The results suggest that mammal species richness within the region may be underestimated by at least 50%, and there are higher levels of endemism and greater intra-specific population structure than previously recognized.
Abstract: Background
Southeast Asia is recognized as a region of very high biodiversity, much of which is currently at risk due to habitat loss and other threats. However, many aspects of this diversity, even for relatively well-known groups such as mammals, are poorly known, limiting ability to develop conservation plans. This study examines the value of DNA barcodes, sequences of the mitochondrial COI gene, to enhance understanding of mammalian diversity in the region and hence to aid conservation planning.
Methodology and Principal Findings
DNA barcodes were obtained from nearly 1900 specimens representing 165 recognized species of bats. All morphologically or acoustically distinct species, based on classical taxonomy, could be discriminated with DNA barcodes except four closely allied species pairs. Many currently recognized species contained multiple barcode lineages, often with deep divergence suggesting unrecognized species. In addition, most widespread species showed substantial genetic differentiation across their distributions. Our results suggest that mammal species richness within the region may be underestimated by at least 50%, and there are higher levels of endemism and greater intra-specific population structure than previously recognized.
Conclusions
DNA barcodes can aid conservation and research by assisting field workers in identifying species, by helping taxonomists determine species groups needing more detailed analysis, and by facilitating the recognition of the appropriate units and scales for conservation planning.
TL;DR: This work reports the Fermi Large Area Telescope detection of variable gamma-ray emission from the recently detected optical nova of the symbiotic star V407 Cygni and proposes that the material of the nova shell interacts with the dense ambient medium of the red giant primary and that particles can be accelerated effectively to produce pi(0) decay gamma-rays from proton-proton interactions.
Abstract: Novae are thermonuclear explosions on a white dwarf surface fueled by mass accreted from a companion star. Current physical models posit that shocked expanding gas from the nova shell can produce x-ray emission, but emission at higher energies has not been widely expected. Here, we report the Fermi Large Area Telescope detection of variable γ-ray emission (0.1 to 10 billion electron volts) from the recently detected optical nova of the symbiotic star V407 Cygni. We propose that the material of the nova shell interacts with the dense ambient medium of the red giant primary and that particles can be accelerated effectively to produce π0 decay γ-rays from proton-proton interactions. Emission involving inverse Compton scattering of the red giant radiation is also considered and is not ruled out.