Moscow State University

About: Moscow State University is a education organization based out in Moscow, Russia. It is known for research contribution in the topics: Laser & Population. The organization has 66747 authors who have published 123358 publications receiving 1753995 citations. The organization is also known as: MSU & Lomonosov Moscow State University.

Idempotent functional analysis: An algebraic approach

Abstract: This paper is devoted to Idempotent Functional Analysis, which is an “abstract” version of Idempotent Analysis developed by V. P. Maslov and his collaborators. We give a brief survey of the basic ideas of Idempotent Analysis. The correspondence between concepts and theorems of traditional Functional Analysis and its idempotent version is discussed in the spirit of N. Bohr's correspondence principle in quantum theory. We present an algebraic approach to Idempotent Functional Analysis. Basic notions and results are formulated in algebraic terms; the essential point is that the operation of idempotent addition can be defined for arbitrary infinite sets of summands. We study idempotent analogs of the basic principles of linear functional analysis and results on the general form of a linear functional and scalar products in idempotent spaces.

Fluorescence polarization immunoassays and related methods for simple, high-throughput screening of small molecules

Abstract: Fluorescence polarization immunoassay (FPIA) is a homogeneous (without separation) competitive immunoassay method based on the increase in fluorescence polarization (FP) of fluorescent-labeled small antigens when bound by specific antibody. The minimum detectable quantity of FPIAs with fluorescein label (about 0.1 ng analyte) is comparable with chromatography and ELISA methods, although this may be limited by sample matrix interference. Because of its simplicity and speed, FPIA is readily automated and therefore suitable for high-throughput screening (HTS) in a variety of application areas. Systems that involve binding of ligands to receptor proteins are also susceptible to analysis by analogous FP methods employing fluorescent-labeled ligand and HTS applications have been developed, notably for use in candidate drug screening.

Upper Limits on the Rates of Binary Neutron Star and Neutron Star-Black Hole Mergers from Advanced LIGO’s First Observing Run

Abstract: We report here the non-detection of gravitational waves from the merger of binary–neutron star systems and neutron star–black hole systems during the first observing run of the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO). In particular, we searched for gravitational-wave signals from binary–neutron star systems with component masses $\in [1,3]\,{M}_{\odot }$ and component dimensionless spins <0.05. We also searched for neutron star–black hole systems with the same neutron star parameters, black hole mass $\in [2,99]\,{M}_{\odot }$, and no restriction on the black hole spin magnitude. We assess the sensitivity of the two LIGO detectors to these systems and find that they could have detected the merger of binary–neutron star systems with component mass distributions of 1.35 ± 0.13 M ⊙ at a volume-weighted average distance of ~70 Mpc, and for neutron star–black hole systems with neutron star masses of 1.4 M ⊙ and black hole masses of at least 5 M ⊙, a volume-weighted average distance of at least ~110 Mpc. From this we constrain with 90% confidence the merger rate to be less than 12,600 Gpc−3 yr−1 for binary–neutron star systems and less than 3600 Gpc−3 yr−1 for neutron star–black hole systems. We discuss the astrophysical implications of these results, which we find to be in conflict with only the most optimistic predictions. However, we find that if no detection of neutron star–binary mergers is made in the next two Advanced LIGO and Advanced Virgo observing runs we would place significant constraints on the merger rates. Finally, assuming a rate of ${10}_{-7}^{+20}$ Gpc−3 yr−1, short gamma-ray bursts beamed toward the Earth, and assuming that all short gamma-ray bursts have binary–neutron star (neutron star–black hole) progenitors, we can use our 90% confidence rate upper limits to constrain the beaming angle of the gamma-ray burst to be greater than $2\buildrel{\circ}\over{.} {3}_{-1.1}^{+1.7}$ ($4\buildrel{\circ}\over{.} {3}_{-1.9}^{+3.1}$).

Nonredundant Function of Soluble LTα3 Produced by Innate Lymphoid Cells in Intestinal Homeostasis

Abstract: Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against pathogens and controls intestinal microbiota composition. However, mechanisms regulating IgA induction are not completely defined. We show that soluble lymphotoxin α (sLTα3) produced by RORγt(+) innate lymphoid cells (ILCs) controls T cell-dependent IgA induction in the lamina propria via regulation of T cell homing to the gut. By contrast, membrane-bound lymphotoxin β (LTα1β2) produced by RORγt(+) ILCs is critical for T cell-independent IgA induction in the lamina propria via control of dendritic cell functions. Ablation of LTα in RORγt(+) cells abrogated IgA production in the gut and altered microbiota composition. Thus, soluble and membrane-bound lymphotoxins produced by ILCs distinctly organize adaptive immune responses in the gut and control commensal microbiota composition.