Moscow State University

About: Moscow State University is a education organization based out in Moscow, Russia. It is known for research contribution in the topics: Catalysis & Laser. The organization has 66747 authors who have published 123358 publications receiving 1753995 citations. The organization is also known as: MSU & Lomonosov Moscow State University.

Applicability domains for classification problems: Benchmarking of distance to models for Ames mutagenicity set.

Abstract: The estimation of accuracy and applicability of QSAR and QSPR models for biological and physicochemical properties represents a critical problem. The developed parameter of “distance to model” (DM) is defined as a metric of similarity between the training and test set compounds that have been subjected to QSAR/QSPR modeling. In our previous work, we demonstrated the utility and optimal performance of DM metrics that have been based on the standard deviation within an ensemble of QSAR models. The current study applies such analysis to 30 QSAR models for the Ames mutagenicity data set that were previously reported within the 2009 QSAR challenge. We demonstrate that the DMs based on an ensemble (consensus) model provide systematically better performance than other DMs. The presented approach identifies 30−60% of compounds having an accuracy of prediction similar to the interlaboratory accuracy of the Ames test, which is estimated to be 90%. Thus, the in silico predictions can be used to halve the cost of exp...

Fractional Ginzburg–Landau equation for fractal media

Abstract: We derive the fractional generalization of the Ginzburg–Landau equation from the variational Euler–Lagrange equation for fractal media. To describe fractal media we use the fractional integrals considered as approximations of integrals on fractals. Some simple solutions of the Ginzburg–Landau equation for fractal media are considered and different forms of the fractional Ginzburg–Landau equation or nonlinear Schrodinger equation with fractional derivatives are presented. The Agrawal variational principle and its generalization have been applied.

Photocatalytic properties of titania powders prepared by hydrothermal method

Abstract: Nanocrystalline titania with particle size ∼20–50 nm and specific surface area ∼20–80 m 2 g −1 is prepared by hydrothermal treatment of aqueous TiOSO 4 , H 2 TiO(C 2 O 4 ) 2 , and TiO(NO 3 ) 2 solutions. The photocatalytic behavior of synthesized TiO 2 powders is studied in the reaction of phenol photodegradation in water and optimal characteristics of these materials are explored. The best photocatalytic activity was observed for a mixture of rutile (15%) and anatase (85%) prepared by high-temperature hydrolysis of aqueous TiOSO 4 solution.

Physical origins and models of energy transfer in photosynthetic light-harvesting

Abstract: We perform a quantitative comparison of different energy transfer theories, i.e. modified Redfield, standard and generalized Forster theories, as well as combined Redfield-Forster approach. Physical limitations of these approaches are illustrated and critical values of the key parameters indicating their validity are found. We model at a quantitative level the spectra and dynamics in two photosynthetic antenna complexes: in phycoerythrin 545 from cryptophyte algae and in trimeric LHCII complex from higher plants. These two examples show how the structural organization determines a directed energy transfer and how equilibration within antenna subunits and migration between subunits are superimposed.

Cell-to-cell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture.

Abstract: The goals of the study were: (1) to explore the communication between human mesenchymal stem cells (MSC) and rat cardiac myocytes resulting in differentiation of the stem cells and, (2) to evaluate the role of mitochondria in it. Light and fluorescence microscopy as well as scanning electron microscopy revealed that after co-cultivation, cells formed intercellular contacts and transient exchange with cytosolic elements could be observed. The transport of cytosolic entity had no specific direction. Noticeably, mitochondria also could be transferred to the recipient cells in a unidirectional fashion (towards cardiomyocytes only). Transmission electron microscopy revealed significant variability in both the diameter of intercellular contacting tubes and their shape. Inside of these nanotubes mitochondria-resembling structures were identified. Moreover, after co-cultivation with cardiomyocytes, expression of human-specific myosin was revealed in MSC. Thus, we speculate that: (1) transport of intracellular elements to MSC possibly can determine the direction of their differentiation and, (2) mitochondria may be involved in the mechanism of the stem cell differentiation. It looks plausible that mitochondrial transfer to recipient cardiomyocytes may be involved in the mechanism of failed myocardium repair after stem cells transplantation.