Motilal Nehru National Institute of Technology Allahabad

About: Motilal Nehru National Institute of Technology Allahabad is a education organization based out in Allahabad, Uttar Pradesh, India. It is known for research contribution in the topics: Computer science & Control theory. The organization has 2475 authors who have published 5067 publications receiving 61891 citations. The organization is also known as: NIT Allahabad & Motilal Nehru Regional Engineering College.

Nanoparticle-based drug delivery systems: promising approaches against infections

Abstract: Despite the fact that many new drugs and technologies have been developed to combat the infectious diseases, these have continued to be global health challenges. The use of conventional antimicrobial agents against these infections is always associated with problems such as the development of multiple drug resistance and adverse side effects. In addition, the inefficient traditional drug delivery system results in inadequate therapeutic index, low bioavailability of drugs and many other limitations. In this regard, antimicrobial nanoparticles and nanosized drug delivery carriers have emerged as potent effective agents against the infections. Nanoparticles have unique properties owing to their ultra small and controllable size such as high surface area, enhanced reactivity, and functionalizable structure. This review focused on different classes of antimicrobial nanoparticles, including metal, metal oxide and others along with their mechanism of action and their potential use against the infections. The review also focused on the development of nanoparticle systems for antimicrobial drug delivery and use of these systems for delivery of various antimicrobial agents, giving an overview about modern nanoparticle based therapeutic strategies against the infections.

Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements.

Abstract: Hesperidin belongs to flavanones class of flavonoids and is known to possess broad-spectrum applicability to prevent dreadful diseases such as cardiovascular disease, neurodegeneration, and cancer....

Performance analysis of graphene based surface plasmon resonance biosensors for detection of pseudomonas-like bacteria

Abstract: The present study investigates the angular responses, sensitivity, detection accuracy and quality parameter of surface plasmon resonance biosensor configuration which is coated with graphene layer for the detection of Pseudomonas and Pseudomonas-like bacteria. The proposed biosensor uses attenuated total reflection method to detect the change in refractive index near the sensor surface. By comparing these results with the conventional gold layer surface plasmon resonance biosensor, it is observed that the overall performance of the proposed biosensor is improved by introducing the graphene layer. Also, the dependence of sensitivity on the number of graphene layers for the proposed sensor is plotted and analyzed.

Adsorption kinetics and molecular interactions of lead [Pb(II)] with natural clay and humic acid

Abstract: Currently, the contamination by lead has become a serious issue to the environment, and many approaches are continuously been searched for its removal from the environment. In the present study, the adsorption potential and interaction of lead [Pb(II)] with natural clay and humic acid were investigated. X-ray diffraction analysis revealed quartz as a dominant mineral in natural clay. Maximum adsorption capacity of both natural clay and humic acid for Pb(II) was 25.07 and 19.16 mg/g, respectively, after the incubation time of 180 min and adsorbate and adsorbent concentrations of 20 mg/L and 10 g/L, respectively. Adsorption capacity of clay was found to be 1.3-folds greater than that of humic acid. Pb(II) adsorption on clay and humic acid was according to the Langmuir isotherm and followed the pseudo-second-order and intraparticle diffusion model kinetics. Fourier transform infrared spectra revealed that Si–O–Si and OH− groups in clay were involved in the interaction with Pb(II); and carboxylic acid, phenolic and alcoholic groups and alkyl halides in humic acid were involved in the interaction with Pb(II). Scanning electron microscopy and energy-dispersive X-ray spectra analysis revealed that Pb(II) adsorption on clay and humic acid occurred by replacement of Mg and Al ions, potentially by ion exchange mechanism. Overall, the results concluded that natural clay and humic acid are promising adsorbents for limiting the mobility of Pb(II) ions in the soil system and aquatic environment, and this could be an effective method for lead waste management.