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Showing papers by "Mulago Hospital published in 1966"


Journal ArticleDOI
G.C. Cook1, S.K. Kajubi1

188 citations



Journal ArticleDOI
G.C. Cook1, F.D. Lee1

83 citations


Journal ArticleDOI
TL;DR: The blood sugar, lactate and pyruvate levels of sixty-nine Ugandan children, during treatment for kwashiorkor, have been studied and the response of the blood glucose to glucagon or adrenaline was twice as great at the end of treatment as at the beginning.
Abstract: 1. The blood sugar, lactate and pyruvate levels of sixty-nine Ugandan children, during treatment for kwashiorkor, have been studied. 2. The majority of untreated cases had low levels of blood glucose but high levels of lactate and pyruvate. Children with the lowest glucose levels had the lowest serum protein values and gained weight more slowly. 3. The response of the blood glucose to glucagon or adrenaline was twice as great at the end of treatment as at the beginning. 4. In children whose treatment was successful the lactate and pyruvate levels gradually fell to the normal range. There was a rise in the blood glucose value but after 3 weeks the level was still below that found in normal African children. In a few children who died or whose treatment was complicated by pyrexia and general apathy there was a rapid fall in lactate and pyruvate concentration to abnormally low levels.

16 citations


Journal ArticleDOI
Denis Burkitt1
TL;DR: Clinicians outside Africa should be aware of this tumor syndrome which, in view of its diversity of clinical manifestations, may pose a diagnostic problem in almost any specialty of medicine.
Abstract: The clinical features,1' 2 pathologic appearances,3' 4and histologic characteristics5 6 of the malignant lymphoma prevalent among children in tropical Africa are now well recognized. Although descriptions of this tumor syndrome usually have been confined to Africa, investigations into its nature and distribution have attracted the attention of cancer research workers in many countries because of the implications that aspects of this tumor may have in other branches of cancer research. In Western countries, this curious neoplasm has aroused more interest among pathologists than among clinicians, in whose eyes this far-off curiosity appeared to have little practical relevance to their work. Although this tumor has not yet been shown to be a common neoplasm in any country outside tropical Africa, with the single exception of New Guinea, it is becoming increasingly apparent that occasional cases occur in many countries with both tropical and temperate climates. Clinicians outside Africa should therefore be aware of this tumor syndrome which, in view of its diversity of clinical manifestations, may pose a diagnostic problem in almost any specialty of medicine. More than 50 per cent of the patients have jaw lesions, and the earliest detectable changes are related to the teeth, so it is of paramount importance that dental surgeons should be aware of these changes. Moreover, since the patient most amenable to treatment is the one in whom the disease is recognized early by the dental surgeon, the importance of confident diagnosis at this stage is evident. INCIDENCE AND GEOGRAPHY.-It was formerly believed that this tumor was virtually limited to the areas in tropical Africa where it is known to be common. It is now apparent that the geographical distribution cannot be simply divided into

14 citations


Journal ArticleDOI
PeterP. Turner1

3 citations