Institution
Mulago Hospital
Healthcare•Kampala, Uganda•
About: Mulago Hospital is a healthcare organization based out in Kampala, Uganda. It is known for research contribution in the topics: Population & Health care. The organization has 542 authors who have published 545 publications receiving 34804 citations.
Topics: Population, Health care, Tuberculosis, Referral, Kwashiorkor
Papers published on a yearly basis
Papers
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2 citations
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TL;DR: A prospective, randomized, controlled, clinical trial comparing short-storage versus longer-storage RBCs for tissue oxygen delivery as measured by reduction of elevated blood lactate levels, improved cerebral oxygen saturation, clinical outcomes, laboratory results, or adverse events found that the two extremes of blood storage duration were found to be not inferior.
2 citations
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01 Apr 20092 citations
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University of Copenhagen1, Population Health Research Institute2, University of La Frontera3, Istanbul Medeniyet University4, University of Western Australia5, King Saud University6, Mulago Hospital7, Sahlgrenska University Hospital8, Rush University Medical Center9, National University of Ireland, Galway10, Cayetano Heredia University11, University of the Philippines12, Glasgow Royal Infirmary13, Dubai Health Authority14, St. John's Medical College15, Eduardo Mondlane University16, University Hospital Bonn17, Universiti Teknologi MARA18
TL;DR: In this article, a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries, was conducted and the authors used multivariable conditional logistic regression to determine the association of renal function with stroke.
Abstract: BACKGROUND Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association. AIMS We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations. METHODS INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. We included individuals with available serum creatinine values and calculated estimated glomerular filtration rate (eGFR). Renal impairment was defined as eGFR <60 mL/min/1.73 m2. Multivariable conditional logistic regression was used to determine the association of renal function with stroke. RESULTS Of 21,127 participants, 41.0% were female, the mean age was 62.3 ± 13.4 years, and the mean eGFR was 79.9 ± 23.5 mL/min/1.73 m2. The prevalence of renal impairment was higher in cases (22.9% vs. 17.7%, p < 0.001) and differed by region (p < 0.001). After adjustment, lower eGFR was associated with increased odds of stroke. Renal impairment was associated with increased odds of all stroke (OR 1.35; 95% CI: 1.24-1.47), with higher odds for intracerebral hemorrhage (OR 1.60; 95% CI: 1.35-1.89) than ischemic stroke (OR 1.29; 95% CI: 1.17-1.42) (pinteraction 0.12). The largest magnitudes of association were seen in younger participants and those living in Africa, South Asia, or South America (pinteraction < 0.001 for all stroke). Renal impairment was also associated with poorer clinical outcome (RRR 2.97; 95% CI: 2.50-3.54 for death within 1 month). CONCLUSION Renal impairment is an important risk factor for stroke, particularly in younger patients, and is associated with more severe stroke and worse outcomes.
2 citations
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2 citations
Authors
Showing all 545 results
Name | H-index | Papers | Citations |
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Moses R. Kamya | 60 | 435 | 12598 |
Jordan J. Feld | 57 | 277 | 13444 |
Eloi Marijon | 47 | 352 | 10005 |
Sarah G. Staedke | 47 | 169 | 6095 |
Harriet Mayanja-Kizza | 43 | 221 | 6804 |
Alphonse Okwera | 42 | 88 | 5187 |
Joo-Hyun Nam | 41 | 231 | 7216 |
James K Tumwine | 41 | 214 | 5413 |
Ian Crozier | 40 | 142 | 7922 |
Cissy Kityo | 39 | 196 | 5926 |
Philippa Musoke | 37 | 138 | 7778 |
Andrew Kambugu | 36 | 184 | 5195 |
Denis Burkitt | 35 | 73 | 8491 |
Richard Idro | 35 | 139 | 4312 |
Robert O. Opoka | 33 | 170 | 4927 |