scispace - formally typeset
Search or ask a question
Institution

Mulago Hospital

HealthcareKampala, Uganda
About: Mulago Hospital is a healthcare organization based out in Kampala, Uganda. It is known for research contribution in the topics: Population & Health care. The organization has 542 authors who have published 545 publications receiving 34804 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: Twinectomy is required for all acute cases but a technique for preservation of the spleen is feasible in the chronic case and the plain abdominal X‐ray is of value in chronic and acute presentations.
Abstract: Eleven cases of wandering spleen are described of which 8 were in children. Six patients presented with a chronic abdominal mass and 5 with acute torsion. In the chronic case the diagnosis may be clarified by the use of radioactive 51 Cr, and the plain abdominal X-ray is of value in chronic and acute presentations. Splenectomy is required for all acute cases but a technique for preservation of the spleen is feasible in the chronic case. The condition may arise from association of splenomegaly and maldevelopment of the dorsal mesogastrium.

70 citations

Journal ArticleDOI
TL;DR: The pathological and clinical features of endomyocardial fibrosis are briefly described, and differential diagnosis is discussed, and attention is drawn to the comparatively high incidence of this disease among Africans at Kampala.
Abstract: 1. (1) The pathological and clinical features of endomyocardial fibrosis (e.m.f.) are briefly described, and differential diagnosis is discussed. 2. (2) Attention is drawn to the comparatively high incidence of this disease among Africans at Kampala. Its incidence in other parts of Africa, and its world distribution, are discussed on the basis of reports of similar cases in the literature and information from other sources. 3. (3) The cause is not known, nor are the pathology nor the clinical manifestations of the earliest lesion. Possible modes of pathogenesis are discussed and possible aetiological factors considered.

69 citations

Journal ArticleDOI
TL;DR: Dysregulation of the S1P pathway in the pathogenesis of human and murine CM is implicate and a novel therapeutic strategy to improve clinical outcome in severe malaria is suggested.
Abstract: Cerebral malaria (CM) Is associated with excessive Inflammatory responses and endothelial activation. Sphingosine 1-phosphate (S1P) is a signaling sphingolipid implicated in regulating vascular integrity, inflammation and T-cell migration. We hypothesized that altered S1P signaling during malaria contributes to endothelial activation and inflammation, and show that plasma S1P levels were decreased in Ugandan children with CM compared with children with uncomplicated malaria. Using the Plasmodium berghei ANKA (PbA) model of experimental CM (ECM), we demonstrate that humanized S1P lyase (hS1PL)−/− mice with reduced S1P lyase activity (resulting in increased bio-available S1P) had improved survival compared with wild-type littermates. Prophylactic and therapeutic treatment of infected mice with compounds that modulate the S1P pathway and are in human trials for other conditions (FTY720 or LX2931) significantly improved survival in ECM. FTY720 treatment improved vascular integrity as indicated by reduced levels of soluble intercellular adhesion molecule (sICAM), increased angiopoietin 1 (Ang1) (regulator of endothelial quiescence) levels, and decreased Evans blue dye leakage into brain parenchyma. Furthermore, treatment with FTY720 decreased IFNγ levels in plasma as well as CD4+ and CD8+ T-cell infiltration into the brain. Finally, when administered during infection in combination with artesunate, FTY720 treatment resulted in increased survival to ECM. These findings implicate dysregulation of the S1P pathway in the pathogenesis of human and murine CM and suggest a novel therapeutic strategy to improve clinical outcome in severe malaria.

68 citations


Authors

Showing all 545 results

NameH-indexPapersCitations
Moses R. Kamya6043512598
Jordan J. Feld5727713444
Eloi Marijon4735210005
Sarah G. Staedke471696095
Harriet Mayanja-Kizza432216804
Alphonse Okwera42885187
Joo-Hyun Nam412317216
James K Tumwine412145413
Ian Crozier401427922
Cissy Kityo391965926
Philippa Musoke371387778
Andrew Kambugu361845195
Denis Burkitt35738491
Richard Idro351394312
Robert O. Opoka331704927
Network Information
Related Institutions (5)
Southampton General Hospital
9.9K papers, 546.6K citations

76% related

Medical Research Council
19.1K papers, 1.4M citations

76% related

Hammersmith Hospital
14.3K papers, 769.1K citations

76% related

Royal Free Hospital
15.7K papers, 651.9K citations

76% related

St Thomas' Hospital
15.5K papers, 624.3K citations

76% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20223
202131
202027
201929
201822
201729